3,5-Diiodo-L-tyrosine dihydrate
- Product Name
- 3,5-Diiodo-L-tyrosine dihydrate
- CAS No.
- 300-39-0
- Chemical Name
- 3,5-Diiodo-L-tyrosine dihydrate
- Synonyms
- (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID
- CBNumber
- CB5490149
- Molecular Formula
- C9H9I2NO3
- Formula Weight
- 432.98
- MOL File
- 300-39-0.mol
3,5-Diiodo-L-tyrosine dihydrate Property
- Melting point:
- 200 °C (dec.)(lit.)
- alpha
- -20.7 º (c=2.5, 0.1N NaOH/H2O)
- Boiling point:
- 546.5°C (rough estimate)
- Density
- 2.405±0.06 g/cm3(Predicted)
- refractive index
- 1.2 ° (C=5, 1mol/L HCl)
- storage temp.
- 2-8°C
- solubility
- Aqueous Acid (Slightly), DMSO (Slightly)
- pka
- 2.12(at 25℃)
- form
- crystalline
- color
- white
- Water Solubility
- slightly soluble
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 300-39-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,5-Diiodo-l-tyrosine(300-39-0)
- EPA Substance Registry System
- L-Tyrosine, 3,5-diiodo- (300-39-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36/37-24/25
- RIDADR
- 2811
- WGK Germany
- 3
- F
- 8
- TSCA
- Yes
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H65420
- Product name
- 3,5-Diiodo-L-tyrosine, 95%
- Packaging
- 25g
- Price
- $66.5
- Updated
- 2021/12/16
- Product number
- H65420
- Product name
- 3,5-Diiodo-L-tyrosine, 95%
- Packaging
- 100g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- D466055
- Product name
- 3,5-Diiodo-L-tyrosine
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- D466055
- Product name
- 3,5-Diiodo-L-tyrosine
- Packaging
- 25g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FD46930
- Product name
- 3,5-Diiodo-L-tyrosine
- Packaging
- 500g
- Price
- $175
- Updated
- 2021/12/16
3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Usage,Production
Description
Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.
Chemical Properties
white to beige powder
Uses
It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.
Uses
3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.
Uses
3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.
Definition
ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.
Synthesis
Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.
Purification Methods
It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]
3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Diiodo-L-tyrosine dihydrate manufacturers
- Product
- 3,5-Diiodo-L-tyrosine dihydrate 300-39-0
- Price
- US $0.00/Kg/Bag
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- 100kgs
- Release date
- 2021-08-23
- Product
- 3,5-Diiodo-L-tyrosine dihydrate 300-39-0
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- 3,5-Diiodo-L-tyrosine dihydrate 300-39-0
- Price
- US $20.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-20