ChemicalBook > CAS DataBase List > 4-(Trifluoromethoxy)benzonitrile

4-(Trifluoromethoxy)benzonitrile

Product Name: 4-(Trifluoromethoxy)benzonitrile
CAS No.: 332-25-2
Chemical Name: 4-(Trifluoromethoxy)benzonitrile
Synonyms: uoromethoxy)benzonitriL;p-trifluoromethoxybenonitrile;p-Cyanotrifluoromethoxybenzene;4-(Trifluoromethoxy)benzonitrile;4-(Trifluoromethoxy)cyanobenzene;4-(Trifluoromethyloxy)benzonitrile;Benzonitrile, 4-(trifluoromethoxy)-;4-(Trifluoromethoxy)benzonitrile 98%;4-(TRIFLUOROMETHOXY)BENZONITRILE 98;For trifluoromethoxy benzene nitrile
CBNumber: CB5499137
Molecular Formula: C8H4F3NO
Formula Weight: 187.12
MOL File: 332-25-2.mol

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4-(Trifluoromethoxy)benzonitrile Property

Boiling point:: 192-193 °C(lit.)
Density: 1.285 g/mL at 25 °C(lit.)
refractive index: n20/D 1.452(lit.)
Flash point:: 181 °F
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
color: Colorless to Almost colorless
BRN: 2832939
InChI: InChI=1S/C8H4F3NO/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H
InChIKey: XWHIXOMWXCHJPP-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference: 332-25-2(CAS DataBase Reference)
EPA Substance Registry System: Benzonitrile, 4-(trifluoromethoxy)- (332-25-2)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39-45
RIDADR: 3276
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2292
Product name: 4-(Trifluoromethoxy)benzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: T2292
Product name: 4-(Trifluoromethoxy)benzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $45
Updated: 2025/07/31

TRC

Product number: T896570
Product name: 4-(Trifluoromethoxy)benzonitrile
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0022369
Product name: 4-(TRIFLUOROMETHOXY)BENZONITRILE
Purity: 95.00%
Packaging: 5G
Price: $768.21
Updated: 2021/12/16

Apolloscientific

Product number: PC7438G
Product name: 4-(Trifluoromethoxy)benzonitrile
Purity: 98%
Packaging: 500g
Price: $183
Updated: 2021/12/16

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4-(Trifluoromethoxy)benzonitrile Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid

General Description

4-(Trifluoromethoxy)benzonitrile serves as an intermediate in the synthesis of fluvoxamine.

Synthesis

1736-74-9

332-25-2

To a 25 mL Schlenk tube equipped with a magnetic stirrer were sequentially added CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-trifluoromethoxybenzyl alcohol (1 mmol) and ammonia (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature for 24 h under balloon protection. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was purified by column chromatography to give p-trifluoromethoxybenzonitrile.

References

[1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 18, p. 3892 - 3896
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466

4-(Trifluoromethoxy)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(Trifluoromethoxy)benzonitrile manufacturers

Career Henan Chemical Co

Product: 4-(Trifluoromethoxy)benzonitrile 332-25-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-27

332-25-2, 4-(Trifluoromethoxy)benzonitrileRelated Search:

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4-(trifluoromethoxy)benzonitrile(SALTDATA: FREE)

For trifluoromethoxy benzene nitrile

4-(TRIFLUOROMETHOXY)BENZONITRILE 98

4-(Trifluoromethoxy)benzonitrile 98%

p-trifluoromethoxybenonitrile

4-(Trifluoromethoxy)benzonitrile

p-Cyanotrifluoromethoxybenzene

Benzonitrile, 4-(trifluoromethoxy)-

4-(Trifluoromethyloxy)benzonitrile

4-(Trifluoromethoxy)cyanobenzene

uoromethoxy)benzonitriL

332-25-2

332-25-9

CF3OC6H4CN

Trifluoroanisole series

Aromatic Nitriles

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C8 to C9

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Nitrile

C8 to C9

Cyanides/Nitriles

Nitrogen Compounds