ChemicalBook > CAS DataBase List > ERYTHROMYCIN LACTOBIONATE (200 MG)

ERYTHROMYCIN LACTOBIONATE (200 MG)

Product Name
ERYTHROMYCIN LACTOBIONATE (200 MG)
CAS No.
3847-29-8
Chemical Name
ERYTHROMYCIN LACTOBIONATE (200 MG)
Synonyms
Erythromycin lactobionate;Erythrocin lactobionate;ERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD);Lactose azithroMycin;Erythomycin lactobionate;Azithromycin lactobionate;Moxifloxacin Impurity 146;Erythromycin iactobionate;Erythromycin lactobionate CRS;ERYTHROMYC LACTOBIONATE (200 MG)
CBNumber
CB5501658
Molecular Formula
C37H67NO13.C12H22O12
Formula Weight
1092.22
MOL File
3847-29-8.mol
More
Less

ERYTHROMYCIN LACTOBIONATE (200 MG) Property

Melting point:
145-150°
Density 
0.9083 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
Refrigerator
solubility 
Soluble in water, freely soluble in anhydrous ethanol and in methanol, very slightly soluble in acetone and in methylene chloride.
form 
Solid
color 
White to Off-White
Water Solubility 
>20g/L(21 ºC)
InChIKey
NNRXCKZMQLFUPL-FACXKIDONA-N
More
Less

Safety

HS Code 
2941500000
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
17189
Product name
Erythromycin lactobionate
Packaging
1g
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
17189
Product name
Erythromycin lactobionate
Packaging
5g
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
17189
Product name
Erythromycin lactobionate
Packaging
500mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17189
Product name
Erythromycin lactobionate
Packaging
10g
Price
$426
Updated
2024/03/01
TRC
Product number
E650040
Product name
ErythromycinLactobionate
Packaging
500mg
Price
$215
Updated
2021/12/16
More
Less

ERYTHROMYCIN LACTOBIONATE (200 MG) Chemical Properties,Usage,Production

Description

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications. Erythromycin lactobionate is a soluble salt of erythromycin that is typically used for intraperitoneal or intravenous injections.

Chemical Properties

White or slightly yellow hygroscopic, powder.

Originator

Erythrocin,Abbott,US,1954

Uses

Erythromycin Lactobionate is an antibiotic used to reduce the prevalence of drug resistant bacteria as well as keeping constant the efficacy of other antibacterial drugs.

Uses

Macrolide antibacterial.

Manufacturing Process

A solution of erythromycin free base is prepared by dissolving 8.0 grams of erythromycin in 25 cc of acetone. 4.0 grams of lactobiono-delta-lactone is dissolved in 25 cc of water. The free lactobionic acid is formed in this solution and it has the molecular formula C12H22O12. The two solutions are mixed and evaporated to a gummy residue. This residue is dissolved in 60 cc of water and the solution is frozen and dried in vacuum by lyophilization. The dried residue of erythromycin lactobionate is a white amorphous powder and weighs 11.7 grams. The reaction product has an activity against B. subtilis of 420units per milligram. Its solubility in water is about 200 mg/cc and the melting point of the white powdery reaction product is 145° to 150°C.

brand name

Erythrocin (Abbott); Erythrocin (Hospira).

Therapeutic Function

Antibacterial

General Description

Erythromycin lactobionate is a water-soluble salt preparedby reacting erythromycin base with lactobiono-σ-lactone. Itoccurs as an amorphous powder that is freely soluble inwater and alcohol and slightly soluble in ether. It is intended,after reconstitution in sterile water, for intravenousadministration to achieve high plasma levels in the treatmentof serious infections.

References

[1] P PERITI. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I).[J]. Clinical Pharmacokinetics, 1989, 16 4: 193-214. DOI: 10.2165/00003088-198916040-00001
[2] G. LEBEK G T. Effects in vitro of erythromycin, alone and in combination with penicillin, on staphylococci, pneumococci and streptococci[J]. Current Medical Research and Opinion, 1978, 5 1: 3-14. DOI: 10.1185/03007997809110242
[3] E AZOULAY-DUPUIS. Antipneumococcal activity of ciprofloxacin, ofloxacin, and temafloxacin in an experimental mouse pneumonia model at various stages of the disease.[J]. Journal of Infectious Diseases, 1991, 163 2: 319-324. DOI: 10.1093/infdis/163.2.319
[4] Y HIRAKATA. Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.[J]. Antimicrobial Agents and Chemotherapy, 1992, 36 6: 1198-1203. DOI: 10.1128/aac.36.6.1198

ERYTHROMYCIN LACTOBIONATE (200 MG) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ERYTHROMYCIN LACTOBIONATE (200 MG) Suppliers

China 128 Germany 1 India 9 South Korea 1 United Kingdom 2 United States 10 Global 151
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Cambrex Pharma & Biopharmaceuticals
Tel
--
Fax
--
Email
pharma@cambrex.com
Country
United States
ProdList
261
Advantage
75
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
More
Less

View Lastest Price from ERYTHROMYCIN LACTOBIONATE (200 MG) manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Erythromycin lactobionate 3847-29-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kgs
Release date
2021-11-16
Shaanxi Dideu Medichem Co. Ltd
Product
ERYTHROMYCIN LACTOBIONATE 3847-29-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
Erythromycin lactobionate 3847-29-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

3847-29-8, ERYTHROMYCIN LACTOBIONATE (200 MG)Related Search:

Sodium lactobionate Sodium dichloroisocyanurate Cefuroxime PotassiuM sodiuM Dehydroandrographolide Succinate Lactobionic acid ERYTHROMYCIN LACTOBIONATE (200 MG) Azithromycin D-(+)-ALLOSE ERYTHROMYCIN A DIHYDRATE BETA-D-ALLOSE Gluconic acid N-DEMETHYL ERYTHROMYCIN A Erythromycin Ammonium-D-xylonate METHYL-BETA-D-RIBOPYRANOSE

  • ERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD)
  • Erythromycin, Lactobionate Salt-N,N-dimethyl-13C2
  • D-Gluconic acid, 4-O-β-D-galactopyranosyl-, compd. with erythromycin (1:1) (9CI)
  • Erythrocin lactobionate
  • Erythromycin, 4-O-β-D-galactopyranosyl-D-gluconate (salt)
  • Erythromycin, compd. with lactobionic acid (7CI)
  • Erythromycin, lactobionate (1:1) (salt)
  • Lactobionic acid, compd. with erythromycin (1:1) (8CI)
  • Azithromycin lactobionate
  • 4-o-beta-d-galactopyranosyl-d-gluconic aci compd. with erythromycin
  • Erythomycin lactobionate
  • lactobionic acid, compd. with erythromycin
  • (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione (2R,
  • Erythromycin lactobionate
  • Lactose azithroMycin
  • ERYTHROMYCIN LACTOBIONATE (200 MG)
  • 4-o-beta-d-galactopyranosyl-d-gluconicacicompd.witherythromycin(1:1)
  • 4-o-beta-d-galactopyranosyl-d-gluconicacidcompd.witherythromycin
  • erythromycinmono(4-o-beta-d-galactopyranosyl-d-gluconate)(salt)
  • lactobionicacid,compd.witherythromycin(1:1)
  • Erythromycin lactobionate CRS
  • ERYTHROMYC LACTOBIONATE (200 MG)
  • ERYTHROMYCIN LACTOBIONATE (200 MG) USP/EP/BP
  • ERYTHROMYCIN LACTOBIONATE USP/EP/BP
  • Erythromycin Lactobionate (1247003)
  • Moxifloxacin Impurity 146
  • Erythromycin iactobionate
  • 3847-29-8
  • C49H87NO24
  • CC48H89NO25
  • C2C47H89NO25
  • C49H89NO25
  • API
  • Peptide Synthesis/Antibiotics