ChemicalBook > CAS DataBase List > 1400 W DIHYDROCHLORIDE, 96

1400 W DIHYDROCHLORIDE, 96

Product Name
1400 W DIHYDROCHLORIDE, 96
CAS No.
214358-33-5
Chemical Name
1400 W DIHYDROCHLORIDE, 96
Synonyms
1400W2HCl;1400W, iNOS inhibitor;1400W (hydrochloride);1400 W DIHYDROCHLORIDE, 96;1400W - CAS 214358-33-5 - Calbiochem;N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride;N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride;inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
CBNumber
CB5502105
Molecular Formula
C8H11NO
Formula Weight
137.17904
MOL File
214358-33-5.mol
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1400 W DIHYDROCHLORIDE, 96 Property

Melting point:
208 °C
storage temp. 
-20°C
solubility 
Soluble in Water (up to 25 mg/ml).
form 
White solid
color 
White
Water Solubility 
Soluble to 100 mM in water
Stability:
Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29242998
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W4262
Product name
1400W dihydrochloride
Purity
>98%, solid
Packaging
10mg
Price
$167
Updated
2024/03/01
Sigma-Aldrich
Product number
100050
Product name
1400W
Packaging
5mg
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
81520
Product name
1400W (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
81520
Product name
1400W (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
81520
Product name
1400W (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$410
Updated
2024/03/01
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1400 W DIHYDROCHLORIDE, 96 Chemical Properties,Usage,Production

Description

1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2

Chemical Properties

white to off-white powder

Uses

A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.

Uses

1400W dihydrochloride has been used:

  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
  • to study its efficacy on renal ischemia/ reperfusion injury in rats
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

General Description

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

Biochem/physiol Actions

Cell permeable: yes

storage

Desiccate at RT

References

References/Citations 1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959 2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300 3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255

1400 W DIHYDROCHLORIDE, 96 Preparation Products And Raw materials

Raw materials

Preparation Products

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1400 W DIHYDROCHLORIDE, 96 Suppliers

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214358-33-5, 1400 W DIHYDROCHLORIDE, 96Related Search:

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Sodium 2-propylpentanoate Vorinostat 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide 2-Methylaminoethanol N-Methyldiethanolamine N-Methylbenzylamine 2-Methyl-2-thiopseudourea sulfate Artemisinin Honokiol 1,4-PBIT DIHYDROBROMIDE L-Canavanine sulfate AMT HYDROCHLORIDE Dimethylbenzyl hydrocarbon chloride Dimethyl benzyl ammonium alkyl chloride 1400W

  • 1400W - CAS 214358-33-5 - Calbiochem
  • 1400 W DIHYDROCHLORIDE, 96
  • 1400W2HCl
  • 1400W (hydrochloride)
  • N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride
  • N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride
  • inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
  • 1400W, iNOS inhibitor
  • 214358-33-5
  • C10H15N32HCl
  • Amines
  • Aromatics
  • Inhibitors
  • Nitric Oxide Reagents