ChemicalBook > CAS DataBase List > 1400 W DIHYDROCHLORIDE, 96

1400 W DIHYDROCHLORIDE, 96

Product Name
1400 W DIHYDROCHLORIDE, 96
CAS No.
214358-33-5
Chemical Name
1400 W DIHYDROCHLORIDE, 96
Synonyms
1400W2HCl;1400W (hydrochloride);1400 W DIHYDROCHLORIDE, 96;1400W - CAS 214358-33-5 - Calbiochem;N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride;N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride;inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
CBNumber
CB5502105
Molecular Formula
C8H11NO
Formula Weight
137.17904
MOL File
214358-33-5.mol
More
Less

1400 W DIHYDROCHLORIDE, 96 Property

Melting point:
208 °C
storage temp. 
-20°C
solubility 
Soluble in Water (up to 25 mg/ml).
form 
White solid
color 
White
Water Solubility 
Soluble to 100 mM in water
Stability:
Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29242998
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W4262
Product name
1400W dihydrochloride
Purity
>98%, solid
Packaging
10mg
Price
$167
Updated
2024/03/01
Sigma-Aldrich
Product number
100050
Product name
1400W
Packaging
5mg
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
81520
Product name
1400W (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
81520
Product name
1400W (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
81520
Product name
1400W (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$410
Updated
2024/03/01
More
Less

1400 W DIHYDROCHLORIDE, 96 Chemical Properties,Usage,Production

Description

1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2

Chemical Properties

white to off-white powder

Uses

A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.

Uses

1400W dihydrochloride has been used:

  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
  • to study its efficacy on renal ischemia/ reperfusion injury in rats
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

General Description

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

Biochem/physiol Actions

Cell permeable: yes

storage

Desiccate at RT

References

References/Citations 1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959 2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300 3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255

1400 W DIHYDROCHLORIDE, 96 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1400 W DIHYDROCHLORIDE, 96 Suppliers

Belgium 1 Canada 1 China 47 Germany 2 Switzerland 1 United Kingdom 2 United States 14 Global 68
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4196
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9708
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9854
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29795
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131980
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16028
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9412
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
ProdList
24734
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
3616
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9992
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10011
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3059
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
6975
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Email
product02@bidepharm.com
Country
China
ProdList
63720
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6749
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24017
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29803
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29990
Advantage
58
Shaanxi kelkai Pharmaceutical Technology Co., Ltd
Tel
029-029-2148545164 17392779578
Email
2148545164@qq.com
Country
China
ProdList
6795
Advantage
58
guoyungurui
Tel
18162595016
Email
3287908757@qq.com
Country
China
ProdList
10012
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32715
Advantage
60
Hangzhou FandaChem Co.,Ltd.
Tel
008657128800458; +8615858145714
Fax
+86-571-56059825
Email
fandachem@gmail.com
Country
China
ProdList
9338
Advantage
55
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43348
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3136
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6942
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6618
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6164
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58

214358-33-5, 1400 W DIHYDROCHLORIDE, 96Related Search:

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Sodium 2-propylpentanoate Vorinostat 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide 2-Methylaminoethanol N-Methyldiethanolamine N-Methylbenzylamine 2-Methyl-2-thiopseudourea sulfate Artemisinin Honokiol 1,4-PBIT DIHYDROBROMIDE L-Canavanine sulfate AMT HYDROCHLORIDE Dimethylbenzyl hydrocarbon chloride Dimethyl benzyl ammonium alkyl chloride 1400W

  • 1400W - CAS 214358-33-5 - Calbiochem
  • 1400 W DIHYDROCHLORIDE, 96
  • 1400W2HCl
  • 1400W (hydrochloride)
  • N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride
  • N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride
  • inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
  • 214358-33-5
  • C10H15N32HCl
  • Amines
  • Aromatics
  • Inhibitors
  • Nitric Oxide Reagents