β-Glycerophosphate disodium salt pentahydrate
- Product Name
- β-Glycerophosphate disodium salt pentahydrate
- CAS No.
- 13408-09-8
- Chemical Name
- β-Glycerophosphate disodium salt pentahydrate
- Synonyms
- trichloromethyl carbonochloridate;β-Glycerophosphate;β-Glycerophosphate (sodium salt hydrate);SodiuM 1,3-dihydroxypropan-2-yl phosphate;β-Glycerophosphate disodium salt pentahydrate;β-Glycerol phosphate disodium salt pentahydrate;Sodium B Glycerophosphate;Disodium β-glycerol phosphate;beta-Glycerophosphate, 200mM soln;Sodium--glycerophosphate, GR 99%+
- CBNumber
- CB5502680
- Molecular Formula
- C3H12NaO7P
- Formula Weight
- 214.09
- MOL File
- 13408-09-8.mol
β-Glycerophosphate disodium salt pentahydrate Property
- Melting point:
- >300°C
- storage temp.
- 2-8°C
- solubility
- H2O: 0.1 g/mL, clear, colorless
- form
- White powder
- color
- Whiteto Off-White
- Water Solubility
- Soluble in water.
- Merck
- 14,8622
- BRN
- 3744328
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C3H9O6P.Na.H2O.H/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;1H2;
- InChIKey
- PEMUISUYOHQFQH-UHFFFAOYSA-L
- SMILES
- O(P(O)(O)=O)C(CO)CO.[NaH].O
Safety
- WGK Germany
- 3
- RTECS
- UA0600000
- F
- 10-21
- TSCA
- Yes
- HS Code
- 29199000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 35675
- Product name
- β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
- Purity
- Aphosphategroupdonorinmatrixmineralizationstudiesthatactsasaprotein
- Packaging
- 50g
- Price
- $56.2
- Updated
- 2024/03/01
- Product number
- 35675
- Product name
- β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
- Purity
- Aphosphategroupdonorinmatrixmineralizationstudiesthatactsasaprotein
- Packaging
- 100g
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- 35675
- Product name
- β-Glycerophosphate, Disodium Salt, Pentahydrate - CAS 13408-09-8 - Calbiochem
- Purity
- Aphosphategroupdonorinmatrixmineralizationstudiesthatactsasaprotein
- Packaging
- 250g
- Price
- $187
- Updated
- 2024/03/01
- Product number
- D3964
- Product name
- Disodium beta-Glycerophosphate Pentahydrate[for Biochemical Research]
- Purity
- >95.0%(T)
- Packaging
- 1g
- Price
- $34
- Updated
- 2024/03/01
- Product number
- D3964
- Product name
- Disodium beta-Glycerophosphate Pentahydrate[for Biochemical Research]
- Purity
- >95.0%(T)
- Packaging
- 5g
- Price
- $71
- Updated
- 2024/03/01
β-Glycerophosphate disodium salt pentahydrate Chemical Properties,Usage,Production
Description
β-
Chemical Properties
Solid
Uses
β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.
Uses
Sodium β-glycerophosphate pentahydrate is used as a phosphatase inhibitor. It promotes bone matrix mineralization while delivering to osteoblasts by providing a source of phosphate ions. It is used in the development of hydrogels and scaffolds, which finds applications in tissue engineering and cell growth. It is used as an additive in isolation mediums by providing phosphate ions to isolate. It is utilized to promote mineralization in vitro by modulating bone cell metabolic activity.
General Description
A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor.
Biochem/physiol Actions
Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression
Purification Methods
Crystallise it from water. [Attwood et al. Biochem J 253 389 1988, Beilstein 1 IV 2766.]
References
[1]. chung ch, golub ee, forbes e, et al. mechanism of action of beta-glycerophosphate on bone cell mineralization. calcif tissue int. 1992 oct;51(4):305-11.
[2]. fujimoto h, mabuchi i. isolation of cleavage furrows from eggs of regular sea urchins and identification of furrow-specific proteins. j biochem. 1997 sep;122(3):518-24.
[3]. lecanda f, avioli lv, cheng sl. regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. j cell biochem. 1997 dec 1;67(3):386-96.
[4]. shioi a, nishizawa y, jono s, et al. beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. arterioscler thromb vasc biol. 1995 nov;15(11):2003-9.
β-Glycerophosphate disodium salt pentahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
β-Glycerophosphate disodium salt pentahydrate Suppliers
View Lastest Price from β-Glycerophosphate disodium salt pentahydrate manufacturers
- Product
- BETA-GLYCEROL PHOSPHATE DISODIUM SALT 13408-09-8
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-22
- Product
- N-(1-NAPHTHYL)-3-AMINOPROPANESULFONIC ACID SODIUM SALT 13408-09-8
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-22
- Product
- PHENYL PHOSPHATE DISODIUM SALT 13408-09-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-24