ChemicalBook > CAS DataBase List > 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE

2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE

Product Name
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
CAS No.
341-88-8
Chemical Name
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
Synonyms
hqno;kf8940;C04284;Pyo II;Antibiotic KF-8940;HQNO, 10 mM in DMSO;NZPACTGCRWDXCJ-UHFFFAOYSA-N;2-heptyl-4-quinolino1-oxide;2-Heptylquinolin-4-ol 1-oxide;2-Heptyl-4-quinolinol 1-oxide
CBNumber
CB5503571
Molecular Formula
C16H21NO2
Formula Weight
259.34
MOL File
341-88-8.mol
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2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Property

Melting point:
156-157°
Boiling point:
445.8±37.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming).
pka
1.07±0.40(Predicted)
form 
White to off-white crystalline solid.
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

RTECS 
VC5890000
Toxicity
LD50 intraperitoneal in mouse: 40mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15159
Product name
HQNO
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15159
Product name
HQNO
Purity
≥98%
Packaging
10mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
15159
Product name
HQNO
Purity
≥98%
Packaging
50mg
Price
$435
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
INB0001935
Product name
2-HEPTYL-4-HYDROXYQUINOLINE-1-OXIDE
Purity
95.00%
Packaging
5MG
Price
$499.44
Updated
2021/12/16
ChemScene
Product number
CS-0104638
Product name
HQNO
Purity
98.04%
Packaging
50mg
Price
$320
Updated
2021/12/16
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2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Chemical Properties,Usage,Production

Description

HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).

Uses

HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin.

Definition

ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide.

References

References/Citations 1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064

2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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341-88-8, 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDERelated Search:

A23187 NONACTIN Nigericin sodium salt (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Pyridine-N-oxide Pyridine-4-carboxylic acid N-oxide QUINOLINE N-OXIDE HYDRATE 2-Pentylpyridine 2-Butylpyridine 4-HYDROXY-2-METHYLQUINOLINE 4-Hydroxy-2-methylpyridine 2-Hexylpyridine Quinoline-N-oxide 4-HYDROXYPYRIDINE-1-OXIDE 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE 2-Ethylquinoline 2-ETHYL-PYRIDINE 1-OXIDE 2-PICOLINE-N-OXIDE

  • 2-(n-heptyl)-4-hydroxyquinolinen-oxide
  • 2-heptyl-4-quinolino1-oxide
  • hqno
  • kf8940
  • 2-Heptylquinolin-4-ol 1-oxide
  • Antibiotic KF-8940
  • Pyo II
  • C04284
  • NZPACTGCRWDXCJ-UHFFFAOYSA-N
  • 2-Heptyl-4-quinolinol 1-oxide
  • 4-Quinolinol, 2-heptyl-, 1-oxide
  • 2-heptyl-4-hydroxyquinolin-1-ium-1-olate
  • electron,transport,Mitochondrial Metabolism,complex III,NDH-2,Inhibitor,HQNO,mitochondrial,chain,inhibit
  • HQNO, antagonist of dihydrostreptomycin
  • HQNO, 10 mM in DMSO
  • 341-88-8