2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- Product Name
- 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- CAS No.
- 341-88-8
- Chemical Name
- 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- Synonyms
- hqno;kf8940;C04284;Pyo II;Antibiotic KF-8940;NZPACTGCRWDXCJ-UHFFFAOYSA-N;2-heptyl-4-quinolino1-oxide;2-Heptylquinolin-4-ol 1-oxide;2-Heptyl-4-quinolinol 1-oxide;4-Quinolinol, 2-heptyl-, 1-oxide
- CBNumber
- CB5503571
- Molecular Formula
- C16H21NO2
- Formula Weight
- 259.34
- MOL File
- 341-88-8.mol
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Property
- Melting point:
- 156-157°
- Boiling point:
- 445.8±37.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming).
- pka
- 1.07±0.40(Predicted)
- form
- White to off-white crystalline solid.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety
- RTECS
- VC5890000
- Toxicity
- LD50 intraperitoneal in mouse: 40mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15159
- Product name
- HQNO
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 15159
- Product name
- HQNO
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 15159
- Product name
- HQNO
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $435
- Updated
- 2024/03/01
- Product number
- INB0001935
- Product name
- 2-HEPTYL-4-HYDROXYQUINOLINE-1-OXIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.44
- Updated
- 2021/12/16
- Product number
- CS-0104638
- Product name
- HQNO
- Purity
- 98.04%
- Packaging
- 50mg
- Price
- $320
- Updated
- 2021/12/16
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Chemical Properties,Usage,Production
Description
HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).
Uses
HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin.
Definition
ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide.
References
References/Citations 1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064