5-BROMO-2-BENZOXAZOLINONE 97
- Product Name
- 5-BROMO-2-BENZOXAZOLINONE 97
- CAS No.
- 14733-73-4
- Chemical Name
- 5-BROMO-2-BENZOXAZOLINONE 97
- Synonyms
- 5-Bromo-benzoxazolinone;5-Bromo-2-benzoxazolone;Venadaparib Impurity 84;5-bromo-2-benzoxazolinon;2-BENZOXAZOLINONE, 5-BROMO-;5-Bromobenzoxazol-2(3H)-one;5-Bromobenzo[d]oxazol-2(3H);5-Bromo-2-hydroxybenzoxazole;5-BROMO-2-BENZOXAZOLINONE 97;5-Bromo-2-benzoxazolinone >
- CBNumber
- CB5505429
- Molecular Formula
- C7H4BrNO2
- Formula Weight
- 214.02
- MOL File
- 14733-73-4.mol
5-BROMO-2-BENZOXAZOLINONE 97 Property
- Melting point:
- 218-222 °C(lit.)
- Boiling point:
- 10.85°C (rough estimate)
- Density
- 1.809
- refractive index
- 1.6120 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 8.46±0.70(Predicted)
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C7H4BrNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
- InChIKey
- DMHTZWJRUUOALC-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(Br)C=C2NC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 653454
- Product name
- 5-Bromo-2-benzoxazolinone
- Purity
- 97%
- Packaging
- 1g
- Price
- $59
- Updated
- 2023/06/20
- Product number
- 653454
- Product name
- 5-Bromo-2-benzoxazolinone
- Purity
- 97%
- Packaging
- 5g
- Price
- $157
- Updated
- 2023/06/20
- Product number
- B4438
- Product name
- 5-Bromo-2-benzoxazolinone
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- B4438
- Product name
- 5-Bromo-2-benzoxazolinone
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- B678103
- Product name
- 5-Bromobenzo[d]oxazol-2(3H)-one
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
5-BROMO-2-BENZOXAZOLINONE 97 Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystalline solid
Synthesis
40925-68-6
530-62-1
14733-73-4
General procedure for the synthesis of 5-bromo-2(3H)-benzoxazolone from 2-amino-4-bromophenol and N,N'-carbonyldiimidazole: Referring to Example 2, to a solution of 2-amino-4-bromophenol (3.50 g, 18.6 mmol) in tetrahydrofuran (100 mL) was slowly added N,N'-carbonyldiimidazole (3.62 g, 22.3 mmol). The reaction mixture was heated to reflux for 1.5 hours. Upon completion of the reaction, the reaction solution was cooled to 20-25 °C, acidified by addition of 2N aqueous hydrochloric acid and subsequently extracted with ethyl acetate. The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride, then dried with anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give 5-bromo-1,3-benzoxazol-2(3H)-one (3.89 g, quantitative yield).IR (cm-1): 960, 1149, 1474, 1622, 1751.
References
[1] Patent: EP1719761, 2006, A1. Location in patent: Page/Page column 26
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 18, p. 5568 - 5582
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8191 - 8195
[4] Synthesis (Germany), 2013, vol. 45, # 23, p. 3269 - 3275
[5] Patent: WO2013/64984, 2013, A1. Location in patent: Page/Page column 125
5-BROMO-2-BENZOXAZOLINONE 97 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-BENZOXAZOLINONE 97 manufacturers
- Product
- 5-BROMO-2-BENZOXAZOLINONE 97 14733-73-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02