ChemicalBook > CAS DataBase List > Fmoc-N-Me-Val-OH

Fmoc-N-Me-Val-OH

Product Name: Fmoc-N-Me-Val-OH
CAS No.: 84000-11-3
Chemical Name: Fmoc-N-Me-Val-OH
Synonyms: FMOC-N-ME-VAL-OH;Fmoc-NaL;(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylbutanoic acid;FMOC-MEVAL-OH;FMOC-L-MEVAL-OH;FMOC-N-ME-VALINE;FMOC-N-ME-L-VAL-OH;FMOC-N-ME-VAL 98.5+%;FMOC-N-METHYL-L-VALINE;Fmoc-N-Methyl-L-Val-OH
CBNumber: CB5663927
Molecular Formula: C21H23NO4
Formula Weight: 353.41
MOL File: 84000-11-3.mol

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Fmoc-N-Me-Val-OH Property

Melting point:: 187-190 °C
alpha: -68 º (c=1% in DMF)
Boiling point:: 527.6±29.0 °C(Predicted)
Density: 1.214±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.92±0.10(Predicted)
form: Powder
color: White
optical activity: [α]20/D 68.0±3°, c = 1% in DMF
Water Solubility: Slightly soluble in water and dimethyl formamide.
BRN: 4560212
InChI: InChI=1S/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/m0/s1
InChIKey: YCXXXPZNQXXRIG-IBGZPJMESA-N
SMILES: C(O)(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C
CAS DataBase Reference: 84000-11-3(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52230
Product name: Fmoc-N-Me-Val-OH
Purity: Novabiochem?
Packaging: 1G
Price: $112
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52230
Product name: Fmoc-N-Me-Val-OH
Purity: Novabiochem?
Packaging: 5G
Price: $451
Updated: 2025/07/31

Sigma-Aldrich

Product number: 47599
Product name: Fmoc-N-Me-Val-OH
Purity: ≥98.0% (sum of enantiomers, HPLC)
Packaging: 1g
Price: $197
Updated: 2023/06/20

TCI Chemical

Product number: F1165
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: F1165
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $206
Updated: 2025/07/31

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Fmoc-N-Me-Val-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

N-Fmoc-N-methyl-L-valine (Fmoc-N-Me-Val-OH) is used as enzyme substrates and reagents, culture media additives, dyes, stains and indicators. It is also involved in the preparation of N-methylated peptides.

General Description

Fmoc-N-Me-Val-OH is a modified peptide. It is provided as a white powder with a molecular formula of C21H23NO4 and a molecular weight of 353.41. This compound is indispensable in peptide and peptidomimetic synthesis applications within the pharmaceutical, biotechnology and chemical sectors.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

84000-01-1

103478-58-6

The general procedure for the synthesis of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl(methyl)amino)-3-methylbutanoic acid from (S)-3-Fmoc-4-isopropyl-5-oxoxoxazolidine was as follows: the Fmoc-valyl oxazolidinone (2.80 g, 8.00 mmol) was dissolved in chloroform (40 mL). To this solution, trifluoroacetic acid (1.85 mL, 24.0 eq.) and triethylsilane (3.83 mL, 24.0 eq.) were added sequentially. The reaction mixture was stirred at room temperature until the reaction was complete (24-72 hours). Upon completion of the reaction, the solution was concentrated and partitioned between ether and 5% sodium bicarbonate solution. The aqueous phases were combined and the pH was adjusted to 2 with 5 M hydrochloric acid, followed by extraction with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated to give Fmoc-N-methylvaline (4) as a white solid (2.35 g, 83% yield).Fmoc-N-methylvaline was recrystallized by ethyl acetate to give white acicular crystals: melting point 186-187 °C (literature value 33: 185-187 °C); low resolution mass spectra (ESI) m/z [M + H ]+ 354.1 (100%), [M + Na]+ 376.1 (61%); IR spectrum (NaCl) νmax (cm-1) 3420 (broad, OH), 2964 (aliphatic CH), 1700 (C=O), 1445, 1305 (C=C); 1H NMR (300 MHz, CDCl3) δH (ppm) 7.63 (2H, d, J=7.5 Hz, ArH), 7.46 (2H, d, J=6.9 Hz, ArH), 7.26 (2H, t, J=7.2 Hz, ArH), 7.17 (2H, t, J=7.5 Hz, ArH), 4.28 (2H, m, CHCH2O), 4.22 (1H, m, (Ar)2CHCH2). 4.13 (1H, m, NCHCO), 2.79 (3H, d, J=4.2 Hz, NCH3), 2.02 (1H, m, CH3CHCH3), 0.88 (3H, dd, J=6.6, 19.2 Hz, CH3CHCH3), 0.72 (3H, dd, J=6.6, 13.8 Hz, CH3CHCH3) ( IR and 1H NMR data are consistent with literature reports); 13C NMR (75 MHz, CDCl3) δC (ppm) 175.5, 159.6, 146.6, 143.9, 130.4, 129.7, 127.7, 122.6, 70.3, 66.9, 49.9, 33.1, 30.2, 22.5, 21.7.

References

[1] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Tetrahedron, 2014, vol. 70, # 14, p. 2351 - 2358

Fmoc-N-Me-Val-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-N-Me-Val-OH manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Fmoc-N-Me-Val-OH 84000-11-3
Price: US $2.00-6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-ton
Release date: 2025-07-28

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-N-Me-Val-OH 84000-11-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-26

Shanghai Getian Industrial Co., LTD

Product: Fmoc-N-Me-Val-OH 84000-11-3
Price: US $28.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 20000
Release date: 2024-04-12

84000-11-3, Fmoc-N-Me-Val-OHRelated Search:

Methyl salicylate Basic Violet 1 9-Fluorenylmethyl chloroformate Valine Methyl acrylate Fmoc-Aib-OH L-Valine Methylparaben 1,1'-Carbonyldiimidazole Kresoxim-methyl Fmoc-Asp(OtBu)-OH Methanol Tribenuron methyl Fmoc-Phe-OH METSULFURON METHYL Fmoc-Lys(Boc)-OH L-Fmoc-Aspartic acid alpha-tert-butyl ester Fmoc-OSu

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valine

(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Val-OH

Fmoc-N-Me-Val-OH (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylbutanoic acid

FMOC-MEVAL-OH

FMOC-N-ALPHA-METHYL-L-VALINE

FMOC-N-ME-VALINE

FMOC-N-ME-VAL-OH

FMOC-N-METHYL-L-VALINE

FMOC-N-ME-L-VAL-OH

FMOC-L-MEVAL-OH

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N-ALPHA-FMOC-N-ALPHA-METHYL-L-VALINE

FMOC-N-ME-VAL 98.5+%

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylbutanoic acid

N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-L-valine

N-FMoc-N-Methyl-L-valine, 95%

N-(9-Fluorenylmethoxycarbonyl)-N-methylvaline

Fmoc-N-methyl-L-valine≥ 98% (HPLC)

2-((((9H-fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)-3-Methylbutanoic acid

L-Valine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methylbutanoic acid

Fmoc-NaL

Fmoc-N-methyl-L-valine USP/EP/BP

FMoc-N-α-Methyl-L-valine

Fmoc-N-Methyl-L-Val-OH

N-Fmoc-N-methyl-L-valine

84000-11-3

Peptide Synthesis

N-Methyl Amino Acids

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino Acids

Valine [Val, V]

N-Methyl Amino Acids

Fmoc-Amino acid series