ChemicalBook > CAS DataBase List > DECURSINOL ANGELATE

DECURSINOL ANGELATE

Product Name
DECURSINOL ANGELATE
CAS No.
130848-06-5
Chemical Name
DECURSINOL ANGELATE
Synonyms
Acutilobin;Decursinol mebutate;DECURSINOL ANGELATE;Decursinolangelate-RM;Decursinol angelate - Bio-X ?;Decursinol angelate, 10 mM in DMSO;(S)-8,8-Dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (Z)-2-methylbut-2-enoate;2-Butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester, (2Z)-
CBNumber
CB5665976
Molecular Formula
C19H20O5
Formula Weight
328.36
MOL File
Mol file
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DECURSINOL ANGELATE Property

Melting point:
93-94 °C
Boiling point:
469.4±45.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25212
Product name
Decursinol angelate
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
25212
Product name
Decursinol angelate
Purity
≥98%
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
25212
Product name
Decursinol angelate
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
25212
Product name
Decursinol angelate
Purity
≥98%
Packaging
25mg
Price
$692
Updated
2024/03/01
ChemScene
Product number
CS-0032746
Product name
Decursinolangelate
Packaging
5mg
Price
$202
Updated
2021/12/16
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DECURSINOL ANGELATE Chemical Properties,Usage,Production

Uses

Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities[1][2].

Biological Activity

Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas th at exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-KB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema.

References

[1] Ahn KS, et al. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 1997 Aug;63(4):360-1. DOI:10.1055/s-2006-957701
[2] Lee S, et al. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res. 2003 Sep;26(9):727-30. DOI:10.1007/BF02976682

DECURSINOL ANGELATE Preparation Products And Raw materials

Raw materials

Preparation Products

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130848-06-5, DECURSINOL ANGELATERelated Search:

NODAKENETIN 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one 3'-Demethylnobiletin 3,3',4',5,6,7,8-heptamethoxyflavone 14,15-beta-dihydroxyklaineanone ANGELIC ACID 13-alpha-(21)-Epoxyeurycomanone Angelicide EUDESMINE 25S-Inokosterone 27-DEOXYACTEIN 25R-Inokosterone Neopentyl glycol diheptanoate 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate CETEARYL OLIVATE Nodakenin Columbianadin Decursinol

  • DECURSINOL ANGELATE
  • Acutilobin
  • Decursinol mebutate
  • 2-Butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester, (2Z)-
  • (S)-8,8-Dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (Z)-2-methylbut-2-enoate
  • Decursinolangelate-RM
  • Decursinol angelate, 10 mM in DMSO
  • Decursinol angelate - Bio-X ?
  • 130848-06-5
  • Miscellaneous Natural Products
  • standard material,plant extracts