ChemicalBook > CAS DataBase List > 6-Amino-1-methyluracil

6-Amino-1-methyluracil

Product Name
6-Amino-1-methyluracil
CAS No.
2434-53-9
Chemical Name
6-Amino-1-methyluracil
Synonyms
6-AMINO-1-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE;Linaint-B;Compound 1530-0259;Valine Impurity 16;6-AMINO-1-METHYLURACI;LABOTEST-BB LT00080647;1-METHYL-6-AMINOURACIL;6-AMINO-1-METHYLURACIL;4-AMINO-3-METHYLURACIL;Ligagliptin Impurity 66
CBNumber
CB5666867
Molecular Formula
C5H7N3O2
Formula Weight
141.13
MOL File
2434-53-9.mol
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6-Amino-1-methyluracil Property

Melting point:
300 °C
Density 
1.339±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in diluted sodium hydroxide solution.
form 
powder to crystal
pka
9.26±0.40(Predicted)
color 
White to Almost white
BRN 
127771
InChI
InChI=1S/C5H7N3O2/c1-8-3(6)2-4(9)7-5(8)10/h2H,6H2,1H3,(H,7,9,10)
InChIKey
GZLZRPNUDBIQBM-UHFFFAOYSA-N
SMILES
C1(=O)N(C)C(N)=CC(=O)N1
CAS DataBase Reference
2434-53-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
346799
Product name
6-Amino-1-methyluracil
Purity
97%
Packaging
25g
Price
$154
Updated
2025/07/31
TCI Chemical
Product number
A2449
Product name
6-Amino-1-methyluracil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$86
Updated
2025/07/31
TCI Chemical
Product number
A2449
Product name
6-Amino-1-methyluracil
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$365
Updated
2021/12/16
TRC
Product number
A616935
Product name
6-Amino-1-methyluracil
Packaging
10g
Price
$120
Updated
2021/12/16
TRC
Product number
A616935
Product name
6-Amino-1-methyluracil
Packaging
50g
Price
$195
Updated
2021/12/16
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6-Amino-1-methyluracil Chemical Properties,Usage,Production

Chemical Properties

almost white to slightly beige crystalline powder

Uses

6-Amino-1-methyluracil may be used in the preparation of 1,1?-di methyl-1H-spiro[pyrimido[4,5-b]quinoline-5,5?-pyrrolo[2,3-d]pyrimidine]-2,2?,4,4?,6?(1?H,3H,3?H,7?H,1?H)-pentaone, via reaction with isatin in the presence of catalytic p-toluene sulfonic acid.

Uses

6-Amino-1-methyluracil is known to exert inhibitory effects towards DNA repair glycosylase. It is also known to be used as a flame retardant.

General Description

6-Amino-1-methyluracil is an amino derivative of uracil and its standard molar enthalpy of combustion has been evaluated. Host-guest complexation of 6-amino-1-methyluracil with tetrapropoxycalix[4]arene has been reported.

Synthesis

105-56-6

598-50-5

2434-53-9

GENERAL METHOD: Ethyl cyanoacetate (0.1 mol) was mixed with N-methylurea (0.1 mol) in anhydrous ethanol (290 mL) containing sodium, and the reaction was carried out with reference to literature methods 26-34. The reaction mixture was refluxed for 10-12 hours and subsequently cooled to room temperature. Acidification was carried out by adjusting the pH to 6 with acetic acid. The resulting precipitate was washed with distilled water and dried in a desiccator overnight.

References

[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 13, p. 2344 - 2350
[2] RSC Advances, 2015, vol. 5, # 28, p. 21464 - 21470
[3] Chemical and Pharmaceutical Bulletin, 2013, vol. 61, # 4, p. 477 - 482
[4] Journal of Chemical Research, 2016, vol. 40, # 12, p. 771 - 777
[5] Patent: EP3299371, 2018, A1. Location in patent: Paragraph 0587; 0588

6-Amino-1-methyluracil Preparation Products And Raw materials

Raw materials

Methylurea Sodium Ethyl cyanoacetate

Preparation Products

8-BROMO-3-METHYL-3,7-DIHYDRO-PURINE-2,6-DIONE
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View Lastest Price from 6-Amino-1-methyluracil manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
6-Amino-1-methyluracil 2434-53-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Shaanxi Dideu Medichem Co. Ltd
Product
6-AMino-1-Methyluracil 2434-53-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
6-Amino-1-methyluracil 2434-53-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-20

2434-53-9, 6-Amino-1-methyluracilRelated Search:

5-Fluorouracil Glycine Methyl acetate Methyl acrylate Kresoxim-methyl Semicarbazide 6-Aminocaproic acid 3-Aminophenol Methylparaben Bensulfuron methyl ALTRENOGEST METSULFURON METHYL Thiophanate-methyl Tris(hydroxymethyl)aminomethane Methyl 2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-3-methyl- 2,4(1H,3H)-Pyrimidinedione, 6-[(3-chloropropyl)amino]-3-methyl- Urapidil Impurity 25

  • 4-AMINO-3-METHYLURACIL
  • 6-AMINO-1-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE
  • 6-AMINO-1-METHYLURACIL
  • 1-METHYL-6-AMINOURACIL
  • LABOTEST-BB LT00080647
  • 6-Amino-1-methyluracil,97%
  • 6-amino-1-methyl-2,4(1h,3h)-pyrimidinedione
  • 6-AMINO-1-METHYLURACIL 98.5%
  • 6-AMINO-1-METHYLURACI
  • 1-Methyl-6-amino-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 1-Methyl-6-aminopyrimidine-2,4(1H,3H)-dione
  • Linaint-B
  • 6-amino-1-methylpyrimidine-2,4-dione
  • 6-Amino-1-methyluracil &gt
  • 2,4(1H,3H)-Pyrimidinedione, 6-amino-1-methyl-
  • 6-Amino-1-methyl-1H-pyrimidine-2,4-dione
  • Compound 1530-0259
  • Valine Impurity 16
  • Urapidil Impurity 16（6-Amino-1-methyluracil）
  • Ligagliptin Impurity 66
  • 2434-53-9
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • API intermediates
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyrimidine series