6-Amino-1-methyluracil
- Product Name
- 6-Amino-1-methyluracil
- CAS No.
- 2434-53-9
- Chemical Name
- 6-Amino-1-methyluracil
- Synonyms
- 6-AMINO-1-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE;Linaint-B;Compound 1530-0259;Valine Impurity 16;6-AMINO-1-METHYLURACI;LABOTEST-BB LT00080647;1-METHYL-6-AMINOURACIL;6-AMINO-1-METHYLURACIL;4-AMINO-3-METHYLURACIL;Ligagliptin Impurity 66
- CBNumber
- CB5666867
- Molecular Formula
- C5H7N3O2
- Formula Weight
- 141.13
- MOL File
- 2434-53-9.mol
6-Amino-1-methyluracil Property
- Melting point:
- 300 °C
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in diluted sodium hydroxide solution.
- form
- powder to crystal
- pka
- 9.26±0.40(Predicted)
- color
- White to Almost white
- BRN
- 127771
- InChI
- InChI=1S/C5H7N3O2/c1-8-3(6)2-4(9)7-5(8)10/h2H,6H2,1H3,(H,7,9,10)
- InChIKey
- GZLZRPNUDBIQBM-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C)C(N)=CC(=O)N1
- CAS DataBase Reference
- 2434-53-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 346799
- Product name
- 6-Amino-1-methyluracil
- Purity
- 97%
- Packaging
- 25g
- Price
- $154
- Updated
- 2025/07/31
- Product number
- A2449
- Product name
- 6-Amino-1-methyluracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- A2449
- Product name
- 6-Amino-1-methyluracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- A616935
- Product name
- 6-Amino-1-methyluracil
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A616935
- Product name
- 6-Amino-1-methyluracil
- Packaging
- 50g
- Price
- $195
- Updated
- 2021/12/16
6-Amino-1-methyluracil Chemical Properties,Usage,Production
Chemical Properties
almost white to slightly beige crystalline powder
Uses
6-Amino-1-methyluracil may be used in the preparation of 1,1?-di methyl-1H-spiro[pyrimido[4,5-b]quinoline-5,5?-pyrrolo[2,3-d]pyrimidine]-2,2?,4,4?,6?(1?H,3H,3?H,7?H,1?H)-pentaone, via reaction with isatin in the presence of catalytic p-toluene sulfonic acid.
Uses
6-Amino-1-methyluracil is known to exert inhibitory effects towards DNA repair glycosylase. It is also known to be used as a flame retardant.
General Description
6-Amino-1-methyluracil is an amino derivative of uracil and its standard molar enthalpy of combustion has been evaluated. Host-guest complexation of 6-amino-1-methyluracil with tetrapropoxycalix[4]arene has been reported.
Synthesis
105-56-6
598-50-5
2434-53-9
GENERAL METHOD: Ethyl cyanoacetate (0.1 mol) was mixed with N-methylurea (0.1 mol) in anhydrous ethanol (290 mL) containing sodium, and the reaction was carried out with reference to literature methods 26-34. The reaction mixture was refluxed for 10-12 hours and subsequently cooled to room temperature. Acidification was carried out by adjusting the pH to 6 with acetic acid. The resulting precipitate was washed with distilled water and dried in a desiccator overnight.
References
[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 13, p. 2344 - 2350
[2] RSC Advances, 2015, vol. 5, # 28, p. 21464 - 21470
[3] Chemical and Pharmaceutical Bulletin, 2013, vol. 61, # 4, p. 477 - 482
[4] Journal of Chemical Research, 2016, vol. 40, # 12, p. 771 - 777
[5] Patent: EP3299371, 2018, A1. Location in patent: Paragraph 0587; 0588
6-Amino-1-methyluracil Preparation Products And Raw materials
Raw materials
Preparation Products
6-Amino-1-methyluracil Suppliers
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View Lastest Price from 6-Amino-1-methyluracil manufacturers
- Product
- 6-Amino-1-methyluracil 2434-53-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 6-AMino-1-Methyluracil 2434-53-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 6-Amino-1-methyluracil 2434-53-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-20