3-Bromo-6-chloro-2-methylpyridine
- Product Name
- 3-Bromo-6-chloro-2-methylpyridine
- CAS No.
- 132606-40-7
- Chemical Name
- 3-Bromo-6-chloro-2-methylpyridine
- Synonyms
- 3-BROMO-6-CHLORO-2-PICOLINE;2-Chloro-5-Bromo-6-Picoline;5-BROMO-2-CHLORO-6-PICOLINE;5-BROMO-2-CHLORO-6-METHYLPYRIDINE;3-BROMO-6-CHLORO-2-METHYL-PYRIDINE;2-methyl -5-bromo 6-chloro pyridine;Pyridine, 3-bromo-6-chloro-2-methyl-;3-Bromo-6-chloro-2-methylpyridine>3-Bromo-6-chloro-2-methylpyridine ISO 9001：2015 REACH
- CBNumber
- CB5673834
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 132606-40-7.mol
3-Bromo-6-chloro-2-methylpyridine Property
- Melting point:
- <40°C
- Boiling point:
- 80-84℃/2mm lit.
- Density
- 1.624±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- pka
- -1.29±0.10(Predicted)
- form
- Liquid
- color
- White or Colorless to Light yellow
- CAS DataBase Reference
- 132606-40-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B4405
- Product name
- 3-Bromo-6-chloro-2-methylpyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $163
- Updated
- 2025/07/31
- Product number
- B690628
- Product name
- 3-Bromo-6-chloro-2-methylpyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC55628
- Product name
- 2-Chloro-5-bromo-6-methylpyridine
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC55628
- Product name
- 2-Chloro-5-bromo-6-methylpyridine
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 3H32-D-Z2
- Product name
- 3-Bromo-6-chloro-2-methylpyridine
- Packaging
- 5G
- Price
- $77
- Updated
- 2021/12/16
3-Bromo-6-chloro-2-methylpyridine Chemical Properties,Usage,Production
Uses
3-Bromo-6-chloro-2-methylpyridine is an organic synthetic reagent for the preparation of difluoropyridine N-oxide and its 4-nitro derivative.
Synthesis
42753-71-9
132606-40-7
General procedure for the synthesis of 5-bromo-2-chloro-6-methylpyridine from 2-amino-5-bromo-6-methylpyridine: dichloromethane (900 mL) was added to a 2L three-necked round-bottomed flask, followed by the addition of 2-amino-6-methyl-5-bromopyridine (74.23 g, 0.39 mol), pyridine hydrochloride (139 g, 1.2 mol), sodium nitrite (83.26 g, 1.2 mol) and cuprous chloride (3.76 g, 5% w/w relative to the feedstock). The reaction mixture was cooled to 0-10 °C in an ice water bath. Hydrochloric acid (4.5 mL, 6% v/w vs. feedstock) was added slowly and stirred at 0-10 °C for 30 min. The cooling bath was removed and the mixture was continued to stir at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (400 mL) and the organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane (100 mL). The organic layers were combined and concentrated to dryness. Hexane (750 mL) was added to the residue and stirred. The solid was collected by filtration, washed with hexane, and the filtrate was concentrated to dryness to afford the pure product 5-bromo-2-chloro-6-methylpyridine (61 g, 70% yield) in light yellow crystalline form.
References
[1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 49
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 2, p. 273 - 276
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 4, p. 569 - 574
[4] Patent: US2005/192310, 2005, A1. Location in patent: Page/Page column 36
[5] Patent: WO2011/28395, 2011, A1. Location in patent: Page/Page column 16
3-Bromo-6-chloro-2-methylpyridine Preparation Products And Raw materials
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View Lastest Price from 3-Bromo-6-chloro-2-methylpyridine manufacturers
- Product
- 5-Bromo-2-chloro-6-methylpyridine 132606-40-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-19
- Product
- 3-Bromo-2-chloro-6-picoline 132606-40-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 3-Bromo-6-chloro-2-methylpyridine 132606-40-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-08