Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

ChemicalBook > CAS DataBase List > Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

Uses

Product Name: Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine
CAS No.: 67579-81-1
Chemical Name: Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine
Synonyms: (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine;t-DMACH;trans-N1,N2-DiMethylcyclohexane-1,2-diaMine;trans-N,N;TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE;TRANS-N,N'-DIMETHYLCYCLOHEXANE-1,2-DIAMINE;trans-N,N'-DimethyL;TRANS-N,N'-DIMETHYLCYCLOHEXANE;(1R,2R)-rel-N1,N2-Dimethyl-1,2-cycloh;trans-N,N'-DiMethylcyclohexane-1,2-diaMin
CBNumber: CB5674518
Molecular Formula: C8H18N2
Formula Weight: 142.24
MOL File: 67579-81-1.mol

Less

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Property

Melting point:: 4°C
Boiling point:: 83 °C / 13mmHg
Density: 0.89
refractive index: n20/D1.472(lit.)
Flash point:: 60℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
form: liquid
pka: 11.04±0.40(Predicted)
color: colorless to pale yellow
Sensitive: air sensitive
InChI: InChI=1/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/s3
InChIKey: JRHPOFJADXHYBR-HTQZYQBOSA-N
SMILES: [C@@H]1(NC)CCCC[C@H]1NC |&1:0,7,r|
CAS DataBase Reference: 67579-81-1(CAS DataBase Reference)

Less

Safety

Hazard Codes: C
Risk Statements: 36/37/38-34-22
Safety Statements: 26-36/37/39-45
RIDADR: 2735
WGK Germany: 3
HazardClass: 8
PackingGroup: Ⅱ
HS Code: 2921309990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 633089
Product name: trans-N,N′-Dimethylcyclohexane-1,2-diamine
Purity: 97%
Packaging: 5ml
Price: $225
Updated: 2024/03/01

Sigma-Aldrich

Product number: 633089
Product name: trans-N,N′-Dimethylcyclohexane-1,2-diamine
Purity: 97%
Packaging: 25ml
Price: $772
Updated: 2024/03/01

TCI Chemical

Product number: D2946
Product name: trans-N,N'-Dimethylcyclohexane-1,2-diamine
Purity: >98.0%(T)
Packaging: 1g
Price: $31
Updated: 2024/03/01

TCI Chemical

Product number: D2946
Product name: trans-N,N'-Dimethylcyclohexane-1,2-diamine
Purity: >98.0%(T)
Packaging: 5g
Price: $90
Updated: 2024/03/01

Strem Chemicals

Product number: 07-0270
Product name: trans-N,N'-Dimethyl-1,2-cyclohexanediamine, 98%
Packaging: 500mg
Price: $60
Updated: 2024/03/01

Less

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Chemical Properties,Usage,Production

Uses

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine used with CuI to form a general and highly efficient catalyst for the N-amidation of aryl and heteroaryl iodides, bromides and in some cases, unactivated aryl chlorides. The catalyst system is also used for the N-arylation of indoles.

Description

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine is a useful research chemical for organic synthesis and other chemical processes.

Uses

trans-N,N′-dimethylcyclohexane-1,2-diamine can be used as a ligand in the synthesis of the following products via copper catalyzed C-N coupling reactions:

vinylsulfoximines obtained from NH sulfoximes and vinyl bromides
N-arylpyridones obtained via reaction between 2-substituted pyridines and aryl halides
N-aryl amines obtained via reaction between amines and aryl iodides/aryl bromides

Synthesis

Cyclohexene oxide (1) was reacted with 25–30% aqueous methylamine (1.5 equiv.) in a sealed reactor to form trans-2-(methylamino)cyclohexanol 2 at 80 °C within 5h. Compound 2 was subjected to Mitsunobu reaction at room temperature, followed by adjusting the pH from 2 to 10 to yield 7-methyl-7-azabicyclo[4.1.0]-heptane 3, which was directly subjected to the following reaction without purification. Ring-opening reactions of compound 3 with a methylamine aqueous solution were completed in a sealed reactor at 110 °C after 6h to yield Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine.

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Suppliers

Americas 1 Australia 1 Canada 1 China 182 Europe 3 Germany 2 India 5 Ireland 1 Italy 1 Japan 1 United Kingdom 7 United States 28 Global 233

AllyChem Co., Ltd.

Tel: 0411-62313318 13942603642
Fax: 0411-87549748
Email: info@allychem.com
Country: China
ProdList: 928
Advantage: 65

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1975
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 11725
Advantage: 58

Tianjin Nuohan Chemical Co., Ltd.

Tel: 166-22132757 13802164402
Fax: QQ：1732062680
Email: zhuxuchen2016@yeah.net
Country: China
ProdList: 74
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9413
Advantage: 66

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9809
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 814
Advantage: 64

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 4000
Advantage: 55

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9459
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Shanghai Huikai Chemical Technology Co., Ltd.

Tel: 021-61995394 18916691159
Email: chemicalsea@163.com
Country: China
ProdList: 1972
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9978
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Sinocompound Catalysts Co., Ltd.

Tel: 0512-67216630 18962121273
Fax: 0512-56316689
Email: sales@sinocompound.com
Country: China
ProdList: 278
Advantage: 64

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 15523000485
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1686
Advantage: 58

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2677
Advantage: 60

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Jiaxing Novartis Chemical Co., Ltd.

Tel: 18957373295
Fax: -
Country: China
ProdList: 1580
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4943
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10276
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 17501653715
Email: xingui2022@126.com
Country: China
ProdList: 10021
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11481
Advantage: 59

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4852
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Giant chemicals

Tel: 028-85434334 18108076537
Fax: QQ：245797092
Email: market@gianthx.com
Country: China
ProdList: 4505
Advantage: 56

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Less

View Lastest Price from Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine manufacturers

Shanghai UCHEM Inc.

Product: trans-N,N'-Dimethyl-1,2-cyclohexanediamine 67579-81-1
Price: US $17.00-114.00/g
Min. Order: 5g
Purity: 0.98
Supply Ability: 25kg
Release date: 2024-04-12

Career Henan Chemical Co

Product: Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine 67579-81-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-24

67579-81-1, Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamineRelated Search:

TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE trans-1,2-Bis(methylamino)cyclohexane, (R,R)-(-)-N,Nμ-Dimethyl-1,2-diaminocyclohexane (1R,2R)-(+)-1,2-DIAMINOCYCLOHEXANE-N,N'-BIS(2'-DIPHENYLPHOSPHINOBENZOYL) (1R,2R)-(+)-1,2-DIAMINOCYCLOHEXANE-N,N'-BIS(2-DIPHENYLPHOSPHINO-1-NAPHTHOYL) N,N'-Dimethyl-1,2-cyclohexanediamine Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine 1,2-Cyclohexylenedinitrilotetraacetic acid (1S)-trans-1,2-Bis(methylamino)cyclohexane, (S,S)-N,Nμ-Dimethyl-1,2-diaminocyclohexane (+/-)-TRANS-1,2-BIS(2-MERCAPTOACETAMIDO)CYCLOHEXANE TRANS-1,2-DIAMINOCYCLOHEXANE-N,N,N',N'-TETRAACETIC ACID MONOHYDRATE (-)-N,N'-(1R,2R)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) (+/-)-TRANS-1,2-BIS(THIOACETATEACETAMIDO)CYCLOHEXANE (+)-U-50488 HYDROCHLORIDE (+/-)-TRANS-1,2-BIS(CHLOROACETAMIDO)CYCLOHEXANE (1R,2R)-N,N,N''N''-TETRAMETHYL-1,2-CYCLOHEXANEDIAMINE (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride (4AR,8AR)-DECAHYDRO-QUINOXALINE

trans-N,N

trans-(1R,2R)-N,N'-BisMethyl-1,2-cyclohexanedia

1,2-CyclohexanediaMine,N1,N2-diMethyl-, (1R,2R)-rel-

trans-N,N'-DiMethylcyclohexane-1,2-diaMin

rel-(1R,2R)-N1,N2-DiMethylcyclohexane-1,2-diaMine

trans-N1,N2-DiMethylcyclohexane-1,2-diaMine

(1R,2R)-rel-N1,N2-DiMethylcyclohexane-1,2-diaMine

TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE

TRANS-N,N'-DIMETHYLCYCLOHEXANE-1,2-DIAMINE

trans-N,N'-Dimethyl-1,2-cyclohexanediamine,98%

TRANS-N,N''-DIMETHYL-1,2-CYCLOHEXANEDIAMINE

(1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine

(1R,2R)-rel-N1,N2-Dimethyl-1,2-cyclohexanediamine

(+/-)-trans-1,2-Diamino-N,N'-dimethylcyclohexane

rel-(1R,2R)-1-N,2-N-diMethylcyclohexane-1,2-diaMine

t-DMACH

Trans-(1R,2R)-N,N'-bisMehtyl-1,2-cyclohexanediaMine

(1R,2R)-rel-N1,N2-Dimethyl-1,2-cyclohexanediamine (Oxaliplatin)

(1R,2R)-rel-N1,N2-Dimethyl-1,2-cycloh

trans-1,2-Bis(methylamino)cyclohexane (Oxaliplatin)

TRANS-N,N'-DIMETHYLCYCLOHEXANE

trans-N,N'-Bismethyl-1,2-cyclohexanediamine

N,N'-Dimethyl-trans-1,2-cyclohexanediamine

trans-N,N'-Dimethylcyclohexane-1,2-diamine&gt

trans-N,N'-DimethyL

1,2-Cyclohexanediamine, N,N'-dimethyl-, (1R,2R)-rel-

rans-N,N'-dimethylcyclohexane-1,2-diamine

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine ISO 9001：2015 REACH

C8H18N2 TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE 67579-81-1

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

trans-N,N'-Dimethyl-1,2-cyclohexanediamine

trans-N,N'-Dimethylcyclohexane-1,2-diamine

trans-N,N'-Bismethyl-1,2-cyclohexanediamine

67579-81-1

C6H10NHCH32

Chiral Nitrogen

DACH&Trost Series

Chiral Reagents

Miscellaneous Reagents