(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine

Product Name: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
CAS No.: 87583-89-9
Chemical Name: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
Synonyms: Dimethylcyclohexanediamine;2S)-N;(S,S)-(+)-N,N;N\'-BisMethyl-1;ohexane-1,2-diamine;(1S,2S)-(+)-N,N'2-cyclohexane-diaMine;(1S,2S)-(+)-N,N'-DimethyL;(1S,2S)-N,N'-Dimethyl-1,2-cyc;N,N'-Dimethyl-1R,2R-Diaminocyclohexane
CBNumber: CB7244380
Molecular Formula: C8H18N2
Formula Weight: 142.24
MOL File: 87583-89-9.mol

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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Property

Melting point:: 39-44 °C
alpha: 145 º (c=4.47 in chloroform)
Boiling point:: 186.8±8.0 °C(Predicted)
Density: 0.902
refractive index: 145 ° (C=4, CHCl3)
Flash point:: 74 °C
storage temp.: 2-8°C
form: Solid
pka: 11.04±0.40(Predicted)
color: Pale brown
optical activity: [α]/D +145±5°, c = 4.47 in chloroform
Water Solubility: Slightly soluble in water.
BRN: 4304824
InChI: InChI=1S/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/m0/s1
InChIKey: JRHPOFJADXHYBR-YUMQZZPRSA-N
SMILES: [C@H]1(NC)CCCC[C@@H]1NC
CAS DataBase Reference: 87583-89-9(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 36/37/38-34-22
Safety Statements: 26-36/37/39-45
RIDADR: UN 3259
WGK Germany: 3
HazardClass: 8
PackingGroup: Ⅱ
HS Code: 29213000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 669660
Product name: (S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine
Purity: ≥97.0% (GC)
Packaging: 1g
Price: $727
Updated: 2023/06/20

TCI Chemical

Product number: D2460
Product name: (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine
Purity: >98.0%(GC)
Packaging: 1g
Price: $98
Updated: 2025/07/31

TCI Chemical

Product number: D2460
Product name: (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine
Purity: >98.0%(GC)
Packaging: 5g
Price: $395
Updated: 2025/07/31

TCI Chemical

Product number: D2460
Product name: (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine
Purity: >98.0%(GC)
Packaging: 100mg
Price: $27
Updated: 2025/07/31

TRC

Product number: D456890
Product name: (1S,2S)-(+)-N,N''-Dimethylcyclohexane-1,2-diamine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Chemical Properties,Usage,Production

Chemical Properties

Beige crystal

Uses

It is employed in the synthesis of 6-substituted 1-oxoindanoyl isoleucine conjugates and modeling studies with the coi1-jaz co-receptor complex of lima bean.

Uses

(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine can be used:

To synthesize derivatives of α-diazophosphonic acid, which are employed in O-H and N-H insertion reactions.
As a starting material for the synthesis of α-chloro-α-alkylphosphonic acids.
To prepare C2 symmetrical diamine enantiomers of C₆₀ with chirospectrosopic properties.

Synthesis

51066-08-1

74-89-5

61798-24-1

The reaction was catalyzed by 2.5 g of inorganic boric acid with epoxycyclohexane (98.2 g, 1.0 mol) and monomethylamine (35% aqueous solution, 1.0 mol) at 50 °C for 2 hours. After the reaction was completed, it was cooled to 0 °C, and 0% sulfuric acid solution (1.0 mol) was slowly added dropwise, controlling the temperature not to exceed 40 °C during the dropwise addition. Subsequently, the temperature was raised to 110 °C to remove water under atmospheric pressure until no water flowed out and the reaction system gradually became viscous. After the addition of 85 mL of cyclobutanesulfone, it was changed to vacuum distillation, and the temperature was gradually increased to 140 °C and maintained for 7-8 h until the moisture content was reduced to 0.38%. Cool the reaction solution to 0 ℃, dropwise add sodium hydroxide aqueous solution to adjust the pH to 12-13. slowly warmed to 75 ℃, the reaction solution gradually clarified, cooled to room temperature and separated the upper layer of liquid 81.9 g, GC purity of 95.2%, the yield of the first two steps was 70%. Add the upper liquid with 35% aqueous methylamine (1.12 mol) and 1.4g of inorganic boric acid into the autoclave, sealed and heated to 90 ℃ overnight, the reaction was completed (external standard yield of 96%). After cooling, the water and the pre-fraction were removed by distillation under reduced pressure to obtain pure N,N'-dimethyl-1,2-cyclohexanediamine. Combining the former fractions, a total of 88.6 g of colorless liquid with 89% yield was obtained, which was nearly white solid after cooling, and the GC purity was 99.2%.

References

[1] Patent: CN106478431, 2017, A. Location in patent: Paragraph 0011; 0012; 0013; 0014; 0015; 0016; 0017; 0018

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Suppliers

Americas 1 China 168 Europe 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 4 United States 20 Global 201

Chengdu Forest Science and Technology Development Co., Ltd.

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Energy Chemical

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Capot Chemical Co., Ltd

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View Lastest Price from (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine manufacturers

Shanghai UCHEM Inc.

Product: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9
Price: US $52.00-119.00/g
Min. Order: 5g
Purity: 0.98
Supply Ability: 100kg
Release date: 2023-12-08

PNP Biotech Co. Ltd

Product: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9
Price: US $0.00/KG
Min. Order: 25KG
Purity: 95%
Supply Ability: Inquiry
Release date: 2022-09-26

Career Henan Chemical Co

Product: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-28

87583-89-9, (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamineRelated Search:

(+/-)-trans-1,2-Diaminocyclohexane N,N-Dimethylformamide 1,2-Diaminocyclohexane trans-1,4-Diaminocyclohexane ETHANE Dimethyl phthalate Dimethyl fumarate Dimethyl ether Dimethyl sulfide Dimethyl sulfoxide 1,2-Cyclohexanedione 1,2-Cyclohexylenedinitrilotetraacetic acid Hexamethylenediamine U-69593 Enadoline Bromadoline U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST (1S,2S)-N,N,N''N''-TETRAMETHYL-1,2-CYCLOHEXANEDIAMINE

TRANS-(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANE-DIAMINE

(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANE-DIAMINE

(1S,2S)-(+)-1,2-BIS(METHYLAMINO)CYCLOHEXANE

Dimethylcyclohexanediamine

(1S)-trans-1,2-Bis(methylamino)cyclohexane, (S,S)-N,Nμ-Dimethyl-1,2-diaminocyclohexane

(S,S)-(+)-N,Nμ-Dimethyl-1,2-cyclohexanediamine

(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine,98%

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine

(S,S)-N,N'-Dimethyl-1,2-diaminocyclohexane

N,N'-Dimethyl-1R,2R-Diaminocyclohexane

2-cyclohexane-diaMine

2S)-N

N\'-BisMethyl-1

N,N'-Dimethyl-(1S,2S)-1,2-Cyclohexanediamine

1,2-Cyclohexanediamine, N1,N2-dimethyl-, (1S,2S)-

(S,S)-(+)-N,N

(S,S)-(+)-N,N'-Dimethyl-1,2-cyclohexanediamine >=97.0% (GC)

(1S,2S)-(+)-trans-1,2-Bis(methylamino)cyclohexane

(1S,2S)-N,N'-Dimethyl-1,2-cyc

(S,S)-N,N'-Dimethyl-1,2-diaminocyclohex

(S,S)-N,N'-Dimethyl-1,2-diaminocyclohexane (Oxaliplatin)

(1,2,S)-(+)-N,N-DIMETHYLCYCLOHEXANE-1,2-DIAMINE

(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine&gt

(1S,2S)-(+)-N,N'-DimethyL

ohexane-1,2-diamine

(1S,2S)-N1,N2-Dimethyl-1,2-cyclohexanediamine

(1S,2S)-N,N'-Dimethylcyclohexane-1,2-diamine

TRANS-(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANEDIAMINE

(1S,2S)-N,N'-Dimethyl-1,2-diaminocyclohexane

(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine

(1S,2S)-(+)-N,N&#39

(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine, CAS 87583-89-9

87583-89-9

Enantiomer Excess & Absolute Conefiguration Determination

e.e. / Absolute Conefiguration Determination (NMR)

Chiral Building Blocks

Amines (Chiral)

Chiral Nitrogen

DACH&Trost Series

Isoquinolines ,Quinolines ,Quinaldines

API intermediates

Amines (Chiral)

Analytical Chemistry

Chiral Building Blocks

e.e. / Absolute Configuration Determination (NMR)

Enantiomer Excess & Absolute Configuration Determination

Synthetic Organic Chemistry