Boc-6-AMinocaproic acid

Product Name: Boc-6-AMinocaproic acid
CAS No.: 6404-29-1
Chemical Name: Boc-6-AMinocaproic acid
Synonyms: Boc-6-AHX;BOC-ACP-OH;Boc-EAhx-OH;BOC-6-ACA-OH;BOC-6-AHX-OH;BOC-E-ACP-OH;BOC-ACP(6)-OH;Boc- ε -Ahx-OH;BOC-NH-(CH2)5-COOH;BOC-EPSILON-ACP-OH
CBNumber: CB5680694
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 6404-29-1.mol

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Boc-6-AMinocaproic acid Property

Melting point:: 35-40 °C
Boiling point:: 166°C/0.3mmHg(lit.)
Density: 1.065±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate
pka: 4.76±0.10(Predicted)
form: Powder
color: White
Water Solubility: Soluble in chloroform and ethyl acetate. Slightly soluble in water.
BRN: 2049561
InChI: InChI=1S/C11H21NO4/c1-11(2,3)16-10(15)12-8-6-4-5-7-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)
InChIKey: RUFDYIJGNPVTAY-UHFFFAOYSA-N
SMILES: C(O)(=O)CCCCCNC(OC(C)(C)C)=O
CAS DataBase Reference: 6404-29-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-26
WGK Germany: 3
F: 21
HazardClass: IRRITANT
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15395
Product name: Boc-6-Ahx-OH
Purity: ≥99.0% (T)
Packaging: 1g
Price: $33.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53059
Product name: Boc-ε-Ahx-OH
Purity: Novabiochem?
Packaging: 25g
Price: $361
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15395
Product name: Boc-6-Ahx-OH
Purity: ≥99.0% (T)
Packaging: 5g
Price: $120
Updated: 2025/07/31

TCI Chemical

Product number: B4275
Product name: N-(tert-Butoxycarbonyl)-6-aminohexanoic Acid
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: B4275
Product name: N-(tert-Butoxycarbonyl)-6-aminohexanoic Acid
Purity: >95.0%(GC)(T)
Packaging: 25g
Price: $235
Updated: 2025/07/31

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Boc-6-AMinocaproic acid Chemical Properties,Usage,Production

Description

Boc-6-aminohexanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Colorless crystal

Uses

6-(Boc-amino)hexanoic acid is used in the preparation of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator.

Uses

Protected ε-Aminocaproic Acid (A603015), Boc-6-AMinocaproic acid can be used in the preparatiom of esters of 6-aminohexanoic acid.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

60-32-2

6404-29-1

General procedure for the synthesis of tert-butoxycarbonyl 6-aminohexanoic acid from 6-aminohexanoic acid (20 g, 153 mmol) and di-tert-butyl dicarbonate (3.67 g, 16.8 mmol): 6-aminohexanoic acid was dissolved in dichloromethane (30 mL) followed by addition of di-tert-butyl dicarbonate. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was filtered and the solvent was removed by distillation under reduced pressure. The crude product was dried under high vacuum to give 4.08 g (115% yield) of the target compound. The product was characterized by 400 MHz 1H NMR (DMSO-d6): δ 2.85 (q, J=13.2,6.8 Hz, 2H), 2.15 (t, J=1.2 Hz, 2H), 1.47-1.43 (m, 4H), 1.34 (s, 9H), 1.22-1.18 (m, 2H). the LCMS analysis showed m/z=232 [M +H]+.

IC 50

Alkyl/ether

References

[1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 13, p. 2450 - 2457
[2] Patent: WO2009/26446, 2009, A2. Location in patent: Page/Page column 30
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4358 - 4369
[4] Chemical Communications, 2006, # 36, p. 3783 - 3785
[5] Synthesis, 1988, # 3, p. 259 - 261

Boc-6-AMinocaproic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-6-AMinocaproic acid Suppliers

Americas 1 China 211 Europe 1 France 1 Germany 7 India 8 Japan 5 Switzerland 4 The Netherlands 1 United Kingdom 5 United States 35 Global 279

SINO High Goal Chemical Technology Co., Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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View Lastest Price from Boc-6-AMinocaproic acid manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Boc-6-Aminohexanoic acid 6404-29-1
Price: US $0.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-26

Career Henan Chemical Co

Product: Boc-6-AMinocaproic acid 6404-29-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-25

6404-29-1, Boc-6-AMinocaproic acidRelated Search:

N-ALPHA-T-BUTYLOXYCARBONYL-L-NORLEUCINE DICYCLOHEXYLAMINE, (S)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID,(S)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID DICYCLOHEXYLAMINE BOC-SAR-OH Boc-N-beta-Trityl-L-asparagine N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-L-aspartic acid 4-tert-butyl ester Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Boc-L-glutamic acid 5-cyclohexyl ester Boc-D-aspartic acid 4-benzyl ester BOC-GLU(OFM)-OH BOC-PHE-SER-ARG-AMC ACETATE SALT BOC-ORN-OH BOC-D-Alanine (BOC-AMINOOXY)ACETIC ACID N-Boc-L-valine Boc-beta-alanine Boc-Arg(Tos)-OH Boc-L-aspartic acid 1-benzyl ester BOC-4-IODO-L-PHENYLALANINE

Boc-6-Ahx-OH ,98.5%(HPLC)

Boc-6-Ahx-OH,6-(Boc-amino)caproic acid, 6-(Boc-amino)hexanoic acid, Boc-6-aminohexanoic acid

Boc-6-Ahx-OH(Boc-6-aMinohexanoic acid)

Boc-ε- AMinocaproic acid Boc-ε- AMinocaproic acid

6-[N-(tert-Butoxycarbonyl)aMino]caproic Acid

N-(tert-Butoxycarbonyl)-ε-aMinocaproic Acid

N-(tert-Butoxycarbonyl)-ε-aMinohexanoic Acid

N-(tert-Butyloxycarbonyl)-ε-aMinocaproic Acid

tert-Butoxycarbonyl-ε-aMinocaproic Acid

Boc-6-aMinohexanoic acid, Boc-eAhx-OH

Boc-e-aMinocaproic acid

Boc-6-Ahx-OH >=99.0% (T)

N-(tert-Butoxycarbonyl)-6-aMinohexanoic Acid, 95.0%,(GC&T

N-(tert-butoxycarbonyl)-6-aminocaproic acid

6-(Boc-amino)caproic acid, 6-(Boc-amino)hexanoic acid, Boc-6-aminohexanoic acid

(Tert-Butoxy)Carbonyl e-Acp-OH

Boc-ε-Acp-OH/Boc-6-Ahx-OH

N-Boc-6-aminohexanoic acid

T-BOC-6-AMINOHEXANOIC ACID

RARECHEM EM WB 0022

N-T-BUTOXYCARBONYL-EPSILON-AMINOCAPROIC ACID

N-T-BUTOXYCARBONYL-EPSILON-AMINOHEXANOIC ACID

N-T-BOC-6-AMINOHEXANOIC ACID

N-TERT-BUTYLOXYCARBONYL-6-AMINO-HEXANOIC ACID

N-EPSILON-T-BOC-EPSILON-AMINOCAPROIC ACID

BOC-NH-(CH2)5-COOH

BOC-EPSILON-ACP-OH

BOC-EPSILON-AHX-OH

BOC-EPSILON-AMINOCAPROIC ACID

BOC-6-ACA-OH

BOC-6-AHX-OH

BOC-6-AMINOCAPROIC ACID

BOC-6-AMINOHEXANOIC ACID

BOC-ACP(6)-OH

BOC-ACP-OH

Boc-EAhx-OH

Boc-ε-Aminocaproic acid

N-T-BUTYLOXYCARBONYL-6-AMINO-HEXANOIC ACID

Boc- ε -Ahx-OH

N-tert-Butoxycarbonyl-6-aminohexanoic acid

BOC-E-ACP-OH

Boc-6-Ahx-OH, >=98%

Boc-6-Aminohexanoic acid≥ 99% (HPLC)

Boc-ε-Ahx-OH Novabiochem

6-(BOC-AMINO)CAPROIC ACID

6-(BOC-AMINO)HEXANOIC ACID

6-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]hexanoic acid

N-(tert-Butoxycarbonyl)-6-aminohexanoic Acid &gt

Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-

Boc-6-aminohexanoicaci

Boc-6-AMinocaproic acid USP/EP/BP

6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid

Boc-6-AHX

Boc-6-aminohexanoic Acid,97%

Boc-6-aminohexanoic acid - 5 g

Boc-6-Ahx-OH/6404-29-1/99%

6-(N-BOC-Amino)-hexanoic acid

6404-29-1