Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate

Product Name: Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate
CAS No.: 3392-05-0
Chemical Name: Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate
Synonyms: Boc-Ala-OSu;BOC-L-ALA-OSU;BOC-D-ALA-OSU;Boc-Ala-OSu, BR;BOC-D-ALANINE-OSU;BOC-L-Alanine-Osu;BOC-ALA-OSU CAS:3392-05-0;(Tert-Butoxy)Carbonyl Ala-OSu;N-Boc-L-alanine N-succinimidyl;Boc-L-Alanine N-hydroxysuccinimde
CBNumber: CB6277666
Molecular Formula: C12H18N2O6
Formula Weight: 286.28
MOL File: 3392-05-0.mol

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Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Property

Melting point:: 161-163 °C
alpha: -52 º (c=2.5% in dioxane)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in water or 1% acetic acid
form: Powder
pka: 10.81±0.46(Predicted)
Appearance: White to off-white Solid
optical activity: [α]20/D 52±3.5°, c = 2.5% in dioxane
Sensitive: Moisture Sensitive
BRN: 3560476
CAS DataBase Reference: 3392-05-0(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 3-10-21
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15385
Product name: Boc-Ala-OSu
Packaging: 5g
Price: $113
Updated: 2023/06/20

TCI Chemical

Product number: B3413
Product name: Boc-Ala-OSu
Packaging: 5G
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: B3413
Product name: Boc-Ala-OSu
Packaging: 25G
Price: $213
Updated: 2025/07/31

Chem-Impex

Product number: 04046
Product name: Boc-L-alanine -hydroxysuccinimide ester
Purity: ≥ 98% (HPLC)
Packaging: 5G
Price: $12.5
Updated: 2021/12/16

Activate Scientific

Product number: AS39017
Product name: Boc-Ala-OSU
Purity: 95% ee
Packaging: 5G
Price: $22
Updated: 2021/12/16

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Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Reactant involved in synthesis of:

Muramyldipeptide analogs via solid-phase synthesis
Microcin C analogs for use as antibacterials
Lipid I and nucleoside diphosphate peptide derivatives via N-methylimidazolium chloride catalyzed coupling
N-Protected dipeptide acids
Free and peptide-bound glycated amino acids for studies of interactions with human Caco-2 interstinal epithelial cell apical membrane transport proteins
7-Substituted camptothecin conjugates with RGD-peptides as avβ3 integrin ligands

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

15761-38-3

107960-02-1

3392-05-0

Example 11: Preparation of N-succinimidyl N-tert-butoxycarbonyl-L-alanine ester 0.95 g (5 mmol) of N-tert-butoxycarbonyl-L-alanine and 0.66 ml (5.5 mmol) of N-methylmorpholine were dissolved in 6 ml of tetrahydrofuran (THF), followed by a one-time addition of 1.8 g (5.5 mmol) of N-succinimidyl 1,2,2,2-tetrachloroethyl carbonate. The reaction mixture was stirred at 20°C for 2 hours. After completion of the reaction, it was diluted by adding about 25 ml of ethyl acetate, and the organic phase was washed quickly with 1N HCl solution, potassium bicarbonate solution in sequence, and finally washed twice with water. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized by ethyl acetate/petroleum ether mixed solvent to give 1.25 g (87% yield) of white crystals. Evaporation of the mother liquor and recrystallization recovered 0.1 g of product, raising the overall yield to 94%. The melting point of the product was 158 °C. [α]D20 = +50.7 (c = 2, dioxane).

References

[1] Journal of Organic Chemistry, 1987, vol. 52, # 12, p. 2364 - 2367
[2] Patent: US4782164, 1988, A

Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Suppliers

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View Lastest Price from Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Ala-OSu 3392-05-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%
Supply Ability: 1T+
Release date: 2024-03-21

Hangzhou ICH Biofarm Co., Ltd

Product: Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate 3392-05-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-06-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate 3392-05-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

3392-05-0, Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionateRelated Search:

BOC-SAR-OH Boc-N-beta-Trityl-L-asparagine N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-L-aspartic acid 4-tert-butyl ester Boc-6-AMinocaproic acid BOC-NLE-OH DCHA Boc-L-glutamic acid 5-cyclohexyl ester Boc-D-aspartic acid 4-benzyl ester BOC-GLU(OFM)-OH BOC-PHE-SER-ARG-AMC ACETATE SALT BOC-ORN-OH Boc-L-2,4-diaminobutyric acid BOC-OIC-OH Boc-D-2,4-diaminobutyric acid BOC-4-IODO-L-PHENYLALANINE BOC-TRP-OSU BOC-MET-OSU BOC-LEU-OSU

BOC-D-ALA-OSU

BOC-D-ALANINE-OSU

BOC-D-ALANINE N-HYDROXYSUCCINIMIDE ESTER

BOC-D-ALANINE-HYDROXYSUCCINIMIDE ESTER

N-ALPHA-T-BOC-D-ALANINE N-HYDROXYSUCCINIMIDE ESTER

succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate

Boc-L-Alanine N-hydroxysuccinimde ester

BOC-L-ALA-OSU

Boc-L-alanineydroxysuccinimidester

Boc-Ala-OSu

Boc-L-alanine N-succinimidyl ester

BOC-ALANINE-1-HYDROXYSUCCINIMIDE ESTER

BOC-L-ALANINE-HYDROXYSUCCINIMIDESTER

N-(tert-butoxycarbonyl)-L-alanine hydroxysuccinimide ester

Boc-L-alanine N-succinimidyl ester, Boc-L-alanine hydroxysuccinimide ester

(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]propionic acid 2,5-dioxopyrrolidin-1-yl ester

[(S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]ethyl]carbamic acid 1,1-dimethylethyl ester

N-(tert-Butoxycarbonyl)alanine 2,5-dioxopyrrolizino

N-(tert-Butoxycarbonyl)-L-alanine 2,5-dioxopyrrolizino

N-(tert-Butyloxycarbonyl)-L-alanine 2,5-dioxopyrrolizino

N-(tert-Butyloxycarbonyl)-L-alanine succinimidyl ester

(2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

2-(tert-butoxycarbonylamino)propionic acid succinimido ester

Succinimido-2-[(tert-butoxycarbonyl)amino]propionate

Boc-L-Alanine N-hydroxysuccinimde

Boc-L-alanineN-hydroxysuccinimide ester≥ 98% (HPLC)

2,5-dioxopyrrolidin-1-yl (2S)-2-{[(tert-butoxy)carbonyl]aMino}propanoate

N-Boc-L-alanine N-succiniMidyl ester, 98%

2,5-dioxopyrrolidin-1-yl 2-{[(tert-butoxy)carbonyl]aMino}propanoate

(Tert-Butoxy)Carbonyl Ala-OSu

(S)-2,5-Dioxopyrrolidin-1-yl2-((tert-butoxycarbonyl)amino)propanoate

Boc-Ala-OSu, BR

N-t-Butoxycarbonyl-L-alanine N-Hydroxysuccinimide Ester

L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester

BOC-ALA-OSU CAS:3392-05-0

Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate USP/EP/BP

BOC-L-Alanine-Osu

Boc-L- alanine N- succinimide ester

N-Boc-L-alanine N-succinimidyl

3392-05-0

C12H18N2O6

Specialty Synthesis

Peptide Synthesis

Amino Acid Derivatives

Alanine

Alanine [Ala, A]

Boc-Amino Acids and Derivative

Boc-Amino acid series

Amino Acid Derivatives

Amino Acids