BOC-SAR-OH
- Product Name
- BOC-SAR-OH
- CAS No.
- 13734-36-6
- Chemical Name
- BOC-SAR-OH
- Synonyms
- BOC-SAR;BOC-SARCOSINE;2-((tert-butoxycarbonyl)(Methyl)aMino)acetic acid;BOC-SAR-OH;BOC-MEGLY-OH;Boc-L-Sar-OH;BOC-N-ME-GLY-OH;N-BOC-SARCOSINE;N-T-BOC-SARCOSIN;N-t-Boc-sarcosine
- CBNumber
- CB2253437
- Molecular Formula
- C8H15NO4
- Formula Weight
- 189.21
- MOL File
- 13734-36-6.mol
BOC-SAR-OH Property
- Melting point:
- 88-90 °C
- Boiling point:
- 324.46°C (rough estimate)
- Density
- 1.2321 (rough estimate)
- refractive index
- 1.4540 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
- form
- Crystals or Crystalline Powder
- pka
- 4.03±0.10(Predicted)
- color
- White
- BRN
- 2046827
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H15NO4/c1-8(2,3)13-7(12)9(4)5-6(10)11/h5H2,1-4H3,(H,10,11)
- InChIKey
- YRXIMPFOTQVOHG-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CN(C(OC(C)(C)C)=O)C
- CAS DataBase Reference
- 13734-36-6(CAS DataBase Reference)
- EPA Substance Registry System
- Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- (13734-36-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 8.53062
- Product name
- Boc-Sar-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $24.6
- Updated
- 2025/07/31
- Product number
- 8.53062
- Product name
- Boc-Sar-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $55.9
- Updated
- 2025/07/31
- Product number
- 8.53062
- Product name
- Boc-Sar-OH
- Purity
- Novabiochem?
- Packaging
- 100g
- Price
- $155
- Updated
- 2025/07/31
- Product number
- 15495
- Product name
- Boc-Sar-OH
- Purity
- ≥99.0% (T)
- Packaging
- 5g
- Price
- $37.1
- Updated
- 2023/06/20
- Product number
- 15495
- Product name
- Boc-Sar-OH
- Purity
- ≥99.0% (T)
- Packaging
- 25g
- Price
- $97.5
- Updated
- 2023/06/20
BOC-SAR-OH Chemical Properties,Usage,Production
Chemical Properties
white crystals or crystalline powder
Uses
Boc-N-methylglycine is used in the preparation of Clavatustide A (C563723) and Clavatustide B (C563725), which have been shown to suppress the proliferation of human hepatocellular carcinoma cells under specific conditions.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
107-97-1
24424-99-5
13734-36-6
Triethylamine (23.5 mL, 168.3 mmol) and di-tert-butyl dicarbonate (12.9 mL, 56.1 mmol) were sequentially added to an aqueous (375 mL) solution of sarcosine (5.0 g, 56.1 mmol), and the reaction mixture was stirred for 6 hours at room temperature. After completion of the reaction, hydrochloric acid solution (320 mL, 1 M aqueous solution) and ethyl acetate were added for acidification and extraction. After separation of the aqueous layer, the aqueous layer was further extracted with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a colorless oil. The oily substance was crystallized at -15 °C to afford the target product 2-((tert-butoxycarbonyl)(methyl)amino)acetic acid (10.6 g, quantitative yield) as a white solid and a mixture of rotary isomers was observed.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 7, p. 602 - 605
[2] Journal of the American Chemical Society, 2003, vol. 125, # 35, p. 10664 - 10671
[3] Synthesis, 1996, # 10, p. 1246 - 1258
[4] Patent: WO2005/39506, 2005, A2. Location in patent: Page/Page column 93-94
[5] Patent: WO2005/39506, 2005, A2. Location in patent: Page/Page column 93-94
BOC-SAR-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-SAR-OH manufacturers
- Product
- Boc-Sar-OH 13734-36-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-11-14
- Product
- BOC-SAR-OH 13734-36-6
- Price
- US $0.00/G/KG
- Min. Order
- 1G/KG
- Purity
- 99%
- Supply Ability
- 10000000KG
- Release date
- 2025-02-12
- Product
- N-Boc-Sarcosine 13734-36-6
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-13