2-AMINO-4-NITROBENZENEMETHANOL
- Product Name
- 2-AMINO-4-NITROBENZENEMETHANOL
- CAS No.
- 78468-34-5
- Chemical Name
- 2-AMINO-4-NITROBENZENEMETHANOL
- Synonyms
- 2-amino-4-nitro-benzylalcoho;2-AMINO-4-NITROBENZYL ALCOHOL;2-AMINO-4-NITROBENZENEMETHANOL;(2-amino-4-nitrophenyl)methanol;Benzenemethanol, 2-amino-4-nitro-;(2-Amino-4-nitrophenyl)methanol, 2-(Hydroxymethyl)-5-nitroaniline
- CBNumber
- CB5695117
- Molecular Formula
- C7H8N2O3
- Formula Weight
- 168.15
- MOL File
- 78468-34-5.mol
2-AMINO-4-NITROBENZENEMETHANOL Property
- Melting point:
- 178-180 °C
- Boiling point:
- 424.1±30.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 13.46±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A619038
- Product name
- 2-Amino-4-nitrobenzenemethanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 071749
- Product name
- 2-Amino-4-nitrobenzenemethanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FA67724
- Product name
- 2-Amino-4-nitrobenzyl alcohol
- Packaging
- 10g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 071749
- Product name
- 2-Amino-4-nitrobenzenemethanol
- Purity
- 95+%
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- W8448
- Product name
- 2-Amino-4-nitrobenzenemethanol
- Packaging
- 5g
- Price
- $151
- Updated
- 2021/12/16
2-AMINO-4-NITROBENZENEMETHANOL Chemical Properties,Usage,Production
Synthesis
619-17-0
78468-34-5
General procedure for the synthesis of (2-amino-4-nitrophenyl)methanol from 2-amino-4-nitrobenzoic acid: 2-amino-4-nitrobenzoic acid (1.00 g, 5.49 mmol) was dissolved in tetrahydrofuran (THF, 20 mL) at room temperature. Borane-tetrahydrofuran complex (BH3-THF, 21.96 mL, 21.96 mmol) was added slowly and dropwise through the addition funnel. The reaction mixture was stirred continuously for 12 hours at room temperature. Upon completion of the reaction, the mixture was cooled in an ice bath and methanol (100 mL) was slowly added to quench the reaction. Subsequently, the reaction mixture was concentrated and the residue was transferred to a split funnel containing saturated aqueous sodium bicarbonate solution (50 mL). The aqueous layer was extracted with ether (3 x 75 mL). The organic layers were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated. The residue was suspended in water, filtered and dried to give (2-amino-4-nitrophenyl)methanol (650 mg, 70% yield) as an orange solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.46 (d, J = 2.0 Hz, 1H), 7.38-7.35 (m, 2H), 5.57 (s, 2H), 5.34 (t, J = 5.4 Hz, 1H), 4.43 (d, J = 5.5 Hz, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[2] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 113
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5080 - 5092
[4] Patent: US2003/195201, 2003, A1
[5] Journal of Organic Chemistry, 2010, vol. 75, # 20, p. 7033 - 7036
2-AMINO-4-NITROBENZENEMETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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