ChemicalBook > CAS DataBase List > 2-AMINO-4-NITROBENZENEMETHANOL

2-AMINO-4-NITROBENZENEMETHANOL

Product Name
2-AMINO-4-NITROBENZENEMETHANOL
CAS No.
78468-34-5
Chemical Name
2-AMINO-4-NITROBENZENEMETHANOL
Synonyms
2-amino-4-nitro-benzylalcoho;2-AMINO-4-NITROBENZYL ALCOHOL;2-AMINO-4-NITROBENZENEMETHANOL;(2-amino-4-nitrophenyl)methanol;Benzenemethanol, 2-amino-4-nitro-;(2-Amino-4-nitrophenyl)methanol, 2-(Hydroxymethyl)-5-nitroaniline
CBNumber
CB5695117
Molecular Formula
C7H8N2O3
Formula Weight
168.15
MOL File
78468-34-5.mol
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2-AMINO-4-NITROBENZENEMETHANOL Property

Melting point:
178-180 °C
Boiling point:
424.1±30.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
13.46±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A619038
Product name
2-Amino-4-nitrobenzenemethanol
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
071749
Product name
2-Amino-4-nitrobenzenemethanol
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67724
Product name
2-Amino-4-nitrobenzyl alcohol
Packaging
10g
Price
$135
Updated
2021/12/16
Matrix Scientific
Product number
071749
Product name
2-Amino-4-nitrobenzenemethanol
Purity
95+%
Packaging
5g
Price
$150
Updated
2021/12/16
AK Scientific
Product number
W8448
Product name
2-Amino-4-nitrobenzenemethanol
Packaging
5g
Price
$151
Updated
2021/12/16
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2-AMINO-4-NITROBENZENEMETHANOL Chemical Properties,Usage,Production

Synthesis

619-17-0

78468-34-5

General procedure for the synthesis of (2-amino-4-nitrophenyl)methanol from 2-amino-4-nitrobenzoic acid: 2-amino-4-nitrobenzoic acid (1.00 g, 5.49 mmol) was dissolved in tetrahydrofuran (THF, 20 mL) at room temperature. Borane-tetrahydrofuran complex (BH3-THF, 21.96 mL, 21.96 mmol) was added slowly and dropwise through the addition funnel. The reaction mixture was stirred continuously for 12 hours at room temperature. Upon completion of the reaction, the mixture was cooled in an ice bath and methanol (100 mL) was slowly added to quench the reaction. Subsequently, the reaction mixture was concentrated and the residue was transferred to a split funnel containing saturated aqueous sodium bicarbonate solution (50 mL). The aqueous layer was extracted with ether (3 x 75 mL). The organic layers were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated. The residue was suspended in water, filtered and dried to give (2-amino-4-nitrophenyl)methanol (650 mg, 70% yield) as an orange solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.46 (d, J = 2.0 Hz, 1H), 7.38-7.35 (m, 2H), 5.57 (s, 2H), 5.34 (t, J = 5.4 Hz, 1H), 4.43 (d, J = 5.5 Hz, 2H).

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[2] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 113
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5080 - 5092
[4] Patent: US2003/195201, 2003, A1
[5] Journal of Organic Chemistry, 2010, vol. 75, # 20, p. 7033 - 7036

2-AMINO-4-NITROBENZENEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4-NITROBENZENEMETHANOL Suppliers

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78468-34-5, 2-AMINO-4-NITROBENZENEMETHANOLRelated Search:

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  • 2-AMINO-4-NITROBENZENEMETHANOL
  • (2-amino-4-nitrophenyl)methanol
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  • 78468-34-5
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