ChemicalBook > CAS DataBase List > Neferine

Neferine

Product Name: Neferine
CAS No.: 2292-16-2
Chemical Name: Neferine
Synonyms: Neferin;NEFERINE;Methylliensinine;Neferine USP/EP/BP;4''-O-Methylliensinine;Neferine, 10 mM in DMSO;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol
CBNumber: CB5706015
Molecular Formula: C38H44N2O6
Formula Weight: 624.77
MOL File: 2292-16-2.mol

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Neferine Property

Melting point:: 59-61 °C
Boiling point:: 710.9±60.0 °C(Predicted)
Density: 1.185±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >15mg/mL
form: powder
pka: 9.28±0.45(Predicted)
color: white to beige
optical activity: [α]/D -34 to -44° (c=0 3. CHCl3)
InChIKey: MIBATSHDJRIUJK-ROJLCIKYSA-N
SMILES: C1(O)=CC=C(C[C@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC1=CC=C(OC)C=C1

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Safety

WGK Germany: 3
RTECS: SM9495000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0349
Product name: Neferine
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $110.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0349
Product name: Neferine
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $453
Updated: 2025/07/31

TRC

Product number: N389200
Product name: Neferine
Packaging: 5mg
Price: $220
Updated: 2021/12/16

Usbiological

Product number: 300672
Product name: Neferine
Packaging: 20mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-5848
Product name: Neferine
Purity: 99.92%
Packaging: 5mg
Price: $55
Updated: 2021/12/16

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Neferine Chemical Properties,Usage,Production

Description

A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.

Chemical Properties

Extracted from the mature green germ of the Nymphaeaceae plant

Uses

Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.

Definition

ChEBI: Neferine is a member of isoquinolines.

Biochem/physiol Actions

Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.

in vivo

Neferine treatment at both low-dose (60 mg/kg/day by gavage) and high-dose (120 mg/kg/day by gavage) reduces the increment of collagen I, III and TGF-β1 protein expression induced by hyperglycemia^[2].

IC 50

p65; Autophagy

References

Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)

Neferine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Neferine manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Neferine 2292-16-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-24

Shanghai Standard Technology Co., Ltd.

Product: Neferine 2292-16-2
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-28

Career Henan Chemical Co

Product: Neferine 2292-16-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

2292-16-2, NeferineRelated Search:

Thiophanate-methyl Vincristine 13,14-Didehydromatridin-15-one Hydroxytyrosol Vincristine sulfate Aloe emodin Kresoxim-methyl Liensinine Bensulfuron methyl Methyl acetate Methylparaben METSULFURON METHYL Methyl acrylate Methyl Parathion-methyl Methyl bromide Isoliensinine Neferine

Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-

4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol

4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol

4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol

Neferin

NEFERINE

4''-O-Methylliensinine

Methylliensinine

4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol

Neferine USP/EP/BP

4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol

Neferine, 10 mM in DMSO

2292-16-2

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate

phytochemical