tert-Butyl diethylphosphonoacetate
- Product Name
- tert-Butyl diethylphosphonoacetate
- CAS No.
- 27784-76-5
- Chemical Name
- tert-Butyl diethylphosphonoacetate
- Synonyms
- tert-butyl 2-(diethoxyphosphoryl)acetate;tert-Butyl diethylph;DIETHYL (BOC-METHYL)PHOSPHONATE;T-BUTYL DIETHYL PHOSPHONOACETATE;Tert-buty diethylphosphonoacetate;tert-Butyl diethylphosponoacetate;Tert-butyl diethylphosphonoactate;TERT-BUTYL DIETHYLPHOSPHONOACETATE;Tert-butyl diehylphosphonoacetate;Tert-butyl diethyl phosphonylacetate
- CBNumber
- CB5708211
- Molecular Formula
- C10H21O5P
- Formula Weight
- 252.24
- MOL File
- 27784-76-5.mol
tert-Butyl diethylphosphonoacetate Property
- Boiling point:
- 100-103 °C/1.5 mmHg (lit.)
- Density
- 1.074 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.431(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Liquid
- Specific Gravity
- 1.074
- color
- Clear colorless
- Water Solubility
- Not miscible or difficult to mix in water.
- BRN
- 2050126
- InChI
- InChI=1S/C10H21O5P/c1-6-13-16(12,14-7-2)8-9(11)15-10(3,4)5/h6-8H2,1-5H3
- InChIKey
- NFEGNISFSSLEGU-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CP(OCC)(OCC)=O
- CAS DataBase Reference
- 27784-76-5(CAS DataBase Reference)
Safety
- Risk Statements
- 36/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 348333
- Product name
- tert-Butyl diethylphosphonoacetate
- Purity
- 95%
- Packaging
- 5g
- Price
- $114
- Updated
- 2023/01/07
- Product number
- B2814
- Product name
- tert-Butyl Diethylphosphonoacetate
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $28
- Updated
- 2024/03/01
- Product number
- B2814
- Product name
- tert-Butyl Diethylphosphonoacetate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $80
- Updated
- 2024/03/01
- Product number
- L17651
- Product name
- tert-Butyl diethylphosphonoacetate, 95%
- Packaging
- 5g
- Price
- $90.65
- Updated
- 2024/03/01
- Product number
- L17651
- Product name
- tert-Butyl diethylphosphonoacetate, 95%
- Packaging
- 1g
- Price
- $29.7
- Updated
- 2021/12/16
tert-Butyl diethylphosphonoacetate Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Uses
tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,?-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates
Synthesis
Triethyl phosphite (485 g) is warmed up to 90°C under N2 atmosphere in a three-necked round-bottomed flask, and /-butyl bromoacetate (541 g) is added dropwise into the system within 2 h. Then, the mixture is stirred at 90°C for around 4 hours and cooled to room temperature. The obtained mixture is distilled under vacuo to remove compounds with low boiling points, and the residue is collected as a colorless liquid tert-butyl diethylphosphonoacetate in 97 percent yield (680 g).
tert-Butyl diethylphosphonoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl diethylphosphonoacetate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28398
- Advantage
- 80
View Lastest Price from tert-Butyl diethylphosphonoacetate manufacturers
- Product
- tert-Butyl diethylphosphonoacetate 27784-76-5
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-01-14
- Product
- tert-Butyl diethylphosphonoacetate 27784-76-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-07-03
- Product
- tert-Butyl diethylphosphonoacetate 27784-76-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-11-04