Ceftiofur hydrochloride
Brand Name(s) in US- Product Name
- Ceftiofur hydrochloride
- CAS No.
- 103980-44-5
- Chemical Name
- Ceftiofur hydrochloride
- Synonyms
- CEFTIOFUR HCL;U-67279A;U 64279A;Excenel RTU;Unii-6822A07436;Ceftiofur hydrochlor;Excenel hydrochloride;CEFTIOFUR HYDROCHLORIDE;-3-(((furan-2-carbonyl);Ceftiovir hydrochloride
- CBNumber
- CB5713789
- Molecular Formula
- C19H18ClN5O7S3
- Formula Weight
- 560.01
- MOL File
- 103980-44-5.mol
Ceftiofur hydrochloride Property
- Melting point:
- >190°C (dec.)
- alpha
- -92～-98°(D/20℃)(c=0.2,CH3OH)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- color
- Off-White
- InChI
- InChI=1/C19H17N5O7S3.ClH/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10;/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28);1H/b23-11-;/t12-,16-;/s3
- InChIKey
- KEQFDTJEEQKVLM-JUODUXDSSA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC(C1OC=CC=1)=O)(=O)O.Cl |&1:5,7,r|
Safety
- WGK Germany
- 3
- HS Code
- 2941906000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 32422
- Product name
- Ceftiofur hydrochloride
- Purity
- VETRANAL
- Packaging
- 100mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 1098071
- Product name
- Ceftiofur hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $1620
- Updated
- 2024/03/01
- Product number
- 27301
- Product name
- Ceftiofur (hydrochloride)
- Packaging
- 1g
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 27301
- Product name
- Ceftiofur (hydrochloride)
- Packaging
- 25g
- Price
- $1002
- Updated
- 2024/03/01
- Product number
- 27301
- Product name
- Ceftiofur (hydrochloride)
- Packaging
- 5g
- Price
- $238
- Updated
- 2024/03/01
Ceftiofur hydrochloride Chemical Properties,Usage,Production
Brand Name(s) in US
Excenel
Description
Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Chemical Properties
Off-White Solid
Uses
An antibacterial.
Uses
Ceftiofur hydrochloride (ceftiofur) has been approved for treatment against respiratory diseases in many animals.1,3,8–10 The recommended dosage regimen of ceftiofur for the treatment of swine respiratory disease is 3–5 mg/kg body weight (BW) administered intramuscularly once daily for 3–5 consecutive days.
Application
Ceftiofur hydrochloride is used for the treatment and control of infections in cattle and pigs caused by susceptible pathogens. It is approved for the treatment of bovine respiratory disease caused by Bartonella mansoni, Bartonella multocida and Bartonella somniferum (formerly Bartonella somniferum).
Ceftiofur hydrochloride is also used for the treatment of bovine interdigital necrotizing bacillosis (rotten foot disease) caused by Fusobacterium necrophorum or Bacteroides melaninogenicus. Ceftiofur hydrochloride has been shown to be effective at a dose of 2.2 mg/kg for the treatment of acute postpartum onychomycosis in dairy cows or by intrauterine instillation (1 g) for the treatment of retained foetal membranes.
Ceftiofur hydrochloride can be used for the treatment of SRD caused by Actinobacillus, Plasmodium multocida, Salmonella cholera and Streptococcus suis.Ceftiofur hydrochloride and ceftiofur amorphous acid can also be administered via the intra-udder route in dairy cows. For intramammary use, a specific formulation (Spectramast DC) is recommended. Although ceftiofur sodium has been used to treat infections in horses and dogs, there is little experience with the administration of ceftiofur sodium hydrochloride in these species.
Veterinary Drugs and Treatments
In swine, ceftiofur HCl injection is labeled for the treatment and
control of swine bacterial respiratory disease (swine bacterial
pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae,
Pasteurella multocida, Salmonella choleraesuis and
Streptococcus suis.
In cattle, ceftiofur HCl is labeled for the treatment of the following
bacterial diseases: Bovine respiratory disease (BRD, shipping
fever, pneumonia) associated with Mannheimia haemolytica,
Pasteurella multocida, and Histophilus somni; Acute bovine interdigital
necrobacillosis (foot rot, pododermatitis) associated with
Fusobacterium necrophorum and Bacteroides melaninogenicus; and
acute metritis (0 – 14 days post-partum) associated with bacterial
organisms susceptible to ceftiofur.
The intramammary syringe for dry dairy cattle (Spectramast
DC?) is labeled for the treatment of subclinical mastitis in dairy
cattle at the time of dry off associated with Staphylococcus aureus,
Streptococcus dysgalactiae, and Streptococcus uberis. The intramammary
syringe for lactating dairy cattle (Spectramast LC?) is labeled
for the treatment of clinical mastitis in lactating dairy cattle associated
with coagulase-negative staphylococci, Streptococcus dysgalactiae,
and Escherichia coli.
Ceftiofur hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ceftiofur hydrochloride Suppliers
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View Lastest Price from Ceftiofur hydrochloride manufacturers
- Product
- Ceftiofur HCl 103980-44-5
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-27
- Product
- Ceftiofur hydrochloride 103980-44-5
- Price
- US $999.00-666.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-13
- Product
- Ceftiofur hydrochloride 103980-44-5
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- ≥91%
- Supply Ability
- 10tongs
- Release date
- 2024-04-23