(R)-(+)-N-Boc-2-piperidinecarboxylic acid

Product Name: (R)-(+)-N-Boc-2-piperidinecarboxylic acid
CAS No.: 28697-17-8
Chemical Name: (R)-(+)-N-Boc-2-piperidinecarboxylic acid
Synonyms: BOC-D-PIP;Boc-D-PIPE;BOC-R-PIP-OH;BOC-D-PIP-OH;BOC-D-HOPRO-OH;BOC-D-PIC(2)-OH;NOC-D-HOMOPRO-OH;BOC-D-HOMOPRO-OH;BOC-D-HOMOPROLINE;Boc-D-beta-homo-Pro
CBNumber: CB5715536
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 28697-17-8.mol

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(R)-(+)-N-Boc-2-piperidinecarboxylic acid Property

Melting point:: 116-119 °C(lit.)
alpha: 68 º (c=1 in acetic acid)
Boiling point:: 353.2±35.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in 2ml dimethyl formamide 0.3gram.
form: Crystalline Powder
pka: 4.03±0.20(Predicted)
color: White to brown
optical activity: [α]23/D 63.5±3°, c = 1 in acetic acid
BRN: 480023
InChIKey: JQAOHGMPAAWWQO-MRVPVSSYSA-N
CAS DataBase Reference: 28697-17-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 516341
Product name: (R)-(+)-N-Boc-2-piperidinecarboxylic acid
Purity: 98%
Packaging: 5g
Price: $121
Updated: 2023/06/20

TRC

Product number: B663858
Product name: (R)-(+)-N-Boc-2-piperidinecarboxylic acid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B663858
Product name: (R)-(+)-N-Boc-2-piperidinecarboxylic acid
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 236197
Product name: Boc-D-homoproline 99+%
Packaging: 1g
Price: $163
Updated: 2021/12/16

Ark Pharm

Product number: P000243513
Product name: Boc-D-HoPro-OH
Purity: 95+%
Packaging: 1g
Price: $7
Updated: 2021/12/16

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(R)-(+)-N-Boc-2-piperidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

It is also applied as catalytic agent and petrochemical additive. It is also an important organic intermediate used in agrochemicals, pharmaceuticals and dyestuff fields.

Uses

(R)-(+)-N-Boc-2-piperidinecarboxylic Acid is a useful intermediate for agrochemical, pharmaceuticals and dye industries.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

1723-00-8

28697-17-8

The general procedure for the synthesis of (R)-1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid from di-tert-butyl dicarbonate and D-(+)-2-piperidinic acid was as follows: to a 1000 mL round-bottomed flask were added D-(+)-2-piperidinic acid (8.0 g, 0.062 mol), di-tert-butyl dicarbonate (14.8 g, 0.068 mol), sodium bicarbonate (26.04 g, 0.310 mol) and methanol (400 mL). The mixture was stirred and reacted at room temperature for 24 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure. The residue was dissolved in water and subsequently washed three times with ether. The pH of the aqueous phase was adjusted to 2 with saturated potassium bisulfate solution and then extracted three times with dichloromethane. The organic phases were combined, washed three times with saturated saline, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of petroleum ether/ethyl acetate/acetic acid, resulting in 12.48 g of white solid product in 87.8% yield. The product was characterized by 1H-NMR (400 MHz, DMSO) and EI-MS: 1H-NMR δ 12.71 (1H, s), 4.61 (1H, d, J = 28.8 Hz), 3.82 (1H, d, J = 12 Hz), 2.93 (1H, m), 2.06 (1H, s), 1.62 (3H, m), 1.39 (11H, m); EI-MS m/z: 229.1 [M]+.

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 591 - 601
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 9, p. 1550 - 1557
[3] ChemMedChem, 2013, vol. 8, # 4, p. 577 - 581
[4] Patent: EP2805947, 2014, A1. Location in patent: Paragraph 0074-0075
[5] Patent: US2015/126500, 2015, A1. Location in patent: Paragraph 0127; 0128

(R)-(+)-N-Boc-2-piperidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-N-Boc-2-piperidinecarboxylic acid Suppliers

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View Lastest Price from (R)-(+)-N-Boc-2-piperidinecarboxylic acid manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: (R)-(+)-N-Boc-2-piperidinecarboxylic acid 28697-17-8
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-07-24

Guangzhou Sunton Biotechnology Co., Ltd.

Product: Boc-D-HomoPro-OH 28697-17-8
Price: US $48.00-40.00/ASSAYS
Min. Order: 1化验
Purity: 99
Supply Ability: 20tons
Release date: 2021-06-04

Shijiazhuang Erche Biotechnology Co., Ltd

Product: Boc-D-HomoPro-OH 28697-17-8
Price: US $100.00-10.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 10000
Release date: 2020-12-22

28697-17-8, (R)-(+)-N-Boc-2-piperidinecarboxylic acidRelated Search:

N-Carbobenzyloxyglycine Triacetonediamine Glycine (S)-1-Boc-piperidine-2-carboxylic acid DROPERIDOL Folic acid Oxygen-fluorine acid Ethyl 2-(Chlorosulfonyl)acetate Levofloxacin carboxylic acid Citric acid Haloperidol DL-Pipecolinic acid DI-TERT-BUTYL ETHER Diphenoxylate D(+)-Pipecolinic acid N-Boc-2-piperidinecarboxylic acid (R)-(+)-N-Boc-2-piperidinecarboxylic acid phosphoric acid

(D)-N-BOC-PIPECOLIC ACID

2-Chloro-4-pyridinecaroboxylic acid

(R)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-2-CARBOXYLIC ACID

N-Boc-D-pipecolinic acid

(R)-Piperidine-2-carboxylic acid, N-BOC protected

D-Pipecolinic acid, N-BOC protected

BOC-D-Homoproline-OH

BOC-D-Picolinic Acid

(D)-N-Boc-2-Piperidine Carboxylic Acid

(+)-N-Boc-(R)-pipecolinic acid, (R)-N-Boc-piperidine-2-carboxylic acid, N-Boc-D-pipecolic acid, (R)-(+)-1-(tert-Butoxycarbonyl)-2-piperidinecarboxylic acid

(+)-N-Boc-(R)-pipecolinic acid, (R)-N-Boc-piperidine-2-carboxylic acid, N-Boc-D-pipecolic acid, Boc-D-Pip-OH, (R)-(+)-1-(tert-Butoxycarbonyl)-2-piperidinecarboxylic acid

Boc-(R)-2-Piperidinecarboxylic acid

Boc-D-Homoproline (Boc-D-Pipecolic acid: Boc-(R)-2-Piperidinecarboxylic acid)

(R)-(+)-N-BOC-2-Piperidinecarboxylic acid,98%

Boc-D-Homoproline (Boc-D-Pipecolic acid

Boc-D-beta-homo-Pro

D-Pipecolinic acid, N-BOC protected, (2R)-1-(tert-Butoxycarbonyl)piperidine-2-carboxylic acid

(R)-1-Boc-2-piperidinecarboxylic acid

N-Boc-(R)-(+)-pipecolic acid

1,2-PIPERIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2R)-

BOC-D-PIP

(Tert-Butoxy)Carbonyl D-HoPro-OH

Boc-D-homoproline99%

(R)-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID

(R)-(-)-N-BOC-PIPECOLIC ACID

(R)-N-BOC-PIPERIDINE-2-CARBOXYLIC ACID

(R)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-2-CARBOXYLIC ACID

(R)-1-N-BOC-PIPECOLINIC ACID

(R)-1-N-BOC-PIPERIDINE-2-CARBOXYLIC ACID

(R)-(+)-1-(TERT-BUTOXYCARBONYL)-2-PIPERIDINECARBOXYLIC ACID

(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-2-CARBOXYLIC ACID

RARECHEM AR PA 0005

NOC-D-HOMOPRO-OH

(+)-N-TBOC-D-PIPECOLINIC ACID

N-BOC-D-PIPECOLIC ACID

(+)-N-BOC-(R)-PIPECOLINIC ACID

N-BOC-(R)-PIPECOLINIC ACID

N-ALPHA-T-BUTOXYCARBONYL-D-HOMOPROLINE

N-ALPHA-T-BUTOXYCARBONYL-D-PIPECOLIC ACID

N-ALPHA-T-BUTOXYCARBONYL-D-PIPECOLINE ACID

N-ALPHA-T-BOC-D-PIPECOLIC ACID

(2R)-1-(TERT-BUTOXYCARBONYL)HEXAHYDROPYRIDINE-2-CARBOXYLIC ACID

(2R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-2-CARBOXYLIC ACID

2(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINECARBOXYLIC ACID

BOC-(R)-(+)-PIPERIDINE-2-CARBOXYLIC ACID

BOC-R-PIP-OH

BOC-D-PIC(2)-OH

BOC-D-(+)-PIPECOLIC ACID

BOC-D-PIPECOLIC ACID

BOC-D-PIPECOLINIC ACID

BOC-D-PIPERIDINE-2-CARBOXYLIC ACID

BOC-D-PIP-OH

BOC-D-HOMOPROLINE

BOC-D-HOMOPRO-OH

BOC-D-HOPRO-OH

(D)-N-(T-BUTOXYCARBONYL)PIPECOLIC ACID

(D)-N-(TERT-BUTOXYCARBONYL)PIPECOLIC ACID