EGS Crosslinker

Product Name: EGS Crosslinker
CAS No.: 70539-42-3
Chemical Name: EGS Crosslinker
Synonyms: EGS;EGNHS;HI-EFF-2B;LAC-4R-886;EGS Crosslinker;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS)
CBNumber: CB5722624
Molecular Formula: C18H20N2O12
Formula Weight: 456.36
MOL File: 70539-42-3.mol

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EGS Crosslinker Property

Boiling point:: 603.4±65.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: acetic acid: water (1:1): ≤50mg/mL
form: powder
color: White to off-white
BRN: 9167119
InChI: InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
InChIKey: QLHLYJHNOCILIT-UHFFFAOYSA-N
SMILES: O(N1C(CCC1=O)=O)C(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(CCC1=O)=O

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Safety

WGK Germany: 3
F: 10
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E3257
Product name: Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity: powder
Packaging: 250mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: E3257
Product name: Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity: powder
Packaging: 1g
Price: $498
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: CHM0014396
Product name: ETHYLENE GLYCOLBIS(SUCCINIMIDYLSUCCINATE)
Purity: 95.00%
Packaging: 1G
Price: $708.48
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK359030
Product name: Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity: 95%
Packaging: 50mg
Price: $39
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK359030
Product name: Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
Purity: 95%
Packaging: 250mg
Price: $126
Updated: 2021/12/16

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EGS Crosslinker Chemical Properties,Usage,Production

Description

EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can react with primary amines.

Uses

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is commonly used as a crosslinker in chemical reactions. It is a homobifunctional crosslinking reagent that is reactive with bromoacetate amines and sulfhydryls.

Biochem/physiol Actions

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.

Properties and Applications

EGS crosslinker, Ethylene glycolbis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker that must be dissolved in DMSO or DMF before addition to an aqueous reaction. EGS crosslinking takes place through amine-reactive NHS esters at both ends of a 16.1-angstrom spacer arm. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable and the spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein crosslinker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins since the molecule is cell membrane permeable. EGS crosslinker is often used in ChIP assays to determine DNA-protein binding interactions. The directly water-soluble analog of EGS is Sulfo-EGS.

EGS Crosslinker Preparation Products And Raw materials

Raw materials

Preparation Products

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EGS Crosslinker Suppliers

China 84 Europe 1 France 1 Germany 3 India 1 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 113

CovaChem, LLC.

Tel: +1815.714.8421 (direct)
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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Aladdin Scientific

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View Lastest Price from EGS Crosslinker manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester) 70539-42-3
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-06

Henan Aochuang Chemical Co.,Ltd.

Product: EGS 70539-42-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: EGS 70539-42-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

70539-42-3, EGS CrosslinkerRelated Search:

2-HYDROXYETHYL ACETATE Ethylenebis(oxyethylenenitrilo)tetraacetic acid 2-(Vinyloxy)ethanol Ethylene Glycol Bis(propionitrile) Ether DST 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) ETHYLENE GLYCOL DISUCCINATE BIS(SULFO-N- DISULFOSUCCINIMIDYL TARTRATE DISUCCINIMIDYL SUBERATE Ethylene glycol ETHYLENE GLYCOLBIS(SULPHOSUCCINIMIDYLSUCCINATE) EGS Crosslinker SULFO-EGS

ethylene glycol-bis(succinic acid n-hydroxysuccinimide

EGNHS

ethyleneglycolylbis(succinimidylsuccinate

ETHYLENE GLYCOL BIS-(SUCCINIC ACID*N-HYD ROXYSUCCINI

Ethlene glycol bis(succinimidyl succinate)

Ethyleneglycol-O,O''-bis-(succinic acid N-hydroxysuccinimide ester)

Di(N-succinimidyl) ethylene glycol disuccinate, EGS, Ethylene glycol bis(succinimidyl succinate), Ethylene glycol disuccinate di(N-succinimidyl) ester

Ethylene Glycol Bis(succinic Acid N-Hydrosuccinimide Ester)

HI-EFF-2B

LAC-4R-886

Butanoic acid, 4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxo-, 1,2-ethanediyl ester

Ethylene glycol bis(succininic acid) N-hydroxysucciniMide ester

Ethylene glycol bis(succiniMidylsuccinate)(EGS)

EGS Crosslinker (ethylene glycol bis(succinimidyl succinate))

DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE

EGS

ETHYLENE GLYCOL-BIS(SUCCINIC ACID N-HYDROXYSUCCINIMIDE ESTER)

ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE)

ETHYLENE GLYCOL DISUCCINATE DI(N-SUCCINIMIDYL) ESTER

Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate

EGS Crosslinker

4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate

Butanedioic acid, 1,1'-(1,2-ethanediyl) 4,4'-bis(2,5-dioxo-1-pyrrolidinyl) ester

ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxob...

ethane-1,2-diyl bis{4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutanoate}

Bis(2,5-dioxopyrrolidin-1-yl) O,O'-ethane-1,2-diyl disuccinate

70539-42-3

C18H20N2O12

Active Esters/Additives

Coupling

Synthetic Reagents

homoXlink

Homobifunctional Crosslinker