3,4-Dimethylphenylhydrazine hydrochloride
- Product Name
- 3,4-Dimethylphenylhydrazine hydrochloride
- CAS No.
- 60481-51-8
- Chemical Name
- 3,4-Dimethylphenylhydrazine hydrochloride
- Synonyms
- LABOTEST-BB LT01148173;Eltrombopag Impurity 63 HCl;3,4-DIMETHYLPHENYLHYDRAZINE HCL;*Fenthion Impurity 18 (Temephos);4-Hydrazino-o-xylene hydrochloride;DiMethylphenylhydrazine hydrochlorid;3,4-DIMETHYLPHENYLHYDRAZINE HYDROCHLORID;3,4-DIMETHYLPHENYLHYDRAZINE HYDOCHLORIDE;3,4-Dimethylphenylhydrazine hydrochloride;3,4-Dimethylphenylhydrazine hydrochloride,98%
- CBNumber
- CB5734328
- Molecular Formula
- C8H13ClN2
- Formula Weight
- 172.66
- MOL File
- 60481-51-8.mol
3,4-Dimethylphenylhydrazine hydrochloride Property
- Melting point:
- 195-200 °C(lit.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder to crystal
- color
- White to Amber to Dark purple
- Water Solubility
- Soluble in water.
- BRN
- 6096060
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H12N2.ClH/c1-6-3-4-8(10-9)5-7(6)2;/h3-5,10H,9H2,1-2H3;1H
- InChIKey
- YYMIOVAEQIEPET-UHFFFAOYSA-N
- SMILES
- N(C1C=CC(C)=C(C)C=1)N.Cl
- CAS DataBase Reference
- 60481-51-8(CAS DataBase Reference)
- EPA Substance Registry System
- Hydrazine, (3,4-dimethylphenyl)-, monohydrochloride (60481-51-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 540455
- Product name
- 3,4-Dimethylphenylhydrazine hydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $325
- Updated
- 2023/06/20
- Product number
- D3616
- Product name
- 3,4-Dimethylphenylhydrazine Hydrochloride
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- D3616
- Product name
- 3,4-Dimethylphenylhydrazine Hydrochloride
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- D457115
- Product name
- 3,4-DimethylphenylhydrazineHydrochlorideSalt
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D457115
- Product name
- 3,4-DimethylphenylhydrazineHydrochlorideSalt
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
3,4-Dimethylphenylhydrazine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White to pink or beige-brown powder
Uses
3,4-Dimethylphenylhydrazine hydrochloride, is used as a reactant with ethyl 3-ethoxy-2-ethoxycarbonylprop-2-enoate to produce 2-(3,4-dimethyl-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester. This reaction will need reagent K2CO3, and the menstruum ethanol.
Synthesis
583-71-1
60481-51-8
General procedure for the synthesis of 3,4-dimethylphenylhydrazine hydrochloride from 4-bromo-1,2-xylene: in a 15 mL screw-top capped test tube, CuBr (36 mg, 0.25 mmol, 2.5 mol%), ligand L3 (110 mg, 0.4 mmol, 4 mol%), H2O (0.5 mL), and K3PO4 (254 mg, 1.2 mmol). STAC (110 mg, 0.3 mmol, 3 mol%) and aryl bromide (10 mmol) were then added and the reaction mixture was stirred at 80-110°C (oil bath temperature) for 10 minutes. Then K3PO4 (2.29 g, 10.8 mmol) and N2H4-H2O (1 g, 20 mmol) were added and argon gas (flow rate 5-7 mL/min) was bubbled through the reaction mixture for 5 minutes. The reaction mixture was stirred in a closed test tube at 80-110°C for 1-2 h. The progress of the reaction was monitored by TLC (eluent: hexane) until the feedstock was completely consumed. After completion of the reaction, it was cooled to room temperature and diluted with dichloromethane (50 mL). The reaction solution was filtered and the organic phase was washed with saturated saline (225 mL). A 37% aqueous HCl solution was added dropwise to the dichloromethane solution and the pH was adjusted to 3-4. The precipitate precipitated was filtered, washed with dichloromethane (15 mL) and dried at room temperature. NMR analysis of the partially synthesized arylhydrazine hydrochloride showed the presence of 1-5 mol% impurities of the corresponding aniline hydrochloride (see Supplementary Data). To obtain an analytically pure sample, the precipitate can be purified by adding 2-3 volumes of diethyl ether from a methanol solution.
References
[1] Chinese Journal of Chemistry, 2018, vol. 36, # 11, p. 1003 - 1006
[2] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048
3,4-Dimethylphenylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Dimethylphenylhydrazine hydrochloride manufacturers
- Product
- 3,4-Dimethylphenylhydrazine hydrochloride 60481-51-8
- Price
- US $10.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-12
- Product
- 3,4-Dimethylphenylhydrazine hydrochloride 60481-51-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%HPLC
- Supply Ability
- 100KG
- Release date
- 2020-02-04