3,4-Dimethylphenylhydrazine hydrochloride

Product Name: 3,4-Dimethylphenylhydrazine hydrochloride
CAS No.: 60481-51-8
Chemical Name: 3,4-Dimethylphenylhydrazine hydrochloride
Synonyms: LABOTEST-BB LT01148173;Eltrombopag Impurity 63 HCl;3,4-DIMETHYLPHENYLHYDRAZINE HCL;*Fenthion Impurity 18 (Temephos);4-Hydrazino-o-xylene hydrochloride;DiMethylphenylhydrazine hydrochlorid;3,4-DIMETHYLPHENYLHYDRAZINE HYDROCHLORID;3,4-DIMETHYLPHENYLHYDRAZINE HYDOCHLORIDE;3,4-Dimethylphenylhydrazine hydrochloride;3,4-Dimethylphenylhydrazine hydrochloride,98%
CBNumber: CB5734328
Molecular Formula: C8H13ClN2
Formula Weight: 172.66
MOL File: 60481-51-8.mol

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3,4-Dimethylphenylhydrazine hydrochloride Property

Melting point:: 195-200 °C(lit.)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
color: White to Amber to Dark purple
Water Solubility: Soluble in water.
BRN: 6096060
Stability:: Hygroscopic
InChI: InChI=1S/C8H12N2.ClH/c1-6-3-4-8(10-9)5-7(6)2;/h3-5,10H,9H2,1-2H3;1H
InChIKey: YYMIOVAEQIEPET-UHFFFAOYSA-N
SMILES: N(C1C=CC(C)=C(C)C=1)N.Cl
CAS DataBase Reference: 60481-51-8(CAS DataBase Reference)
EPA Substance Registry System: Hydrazine, (3,4-dimethylphenyl)-, monohydrochloride (60481-51-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Harmful/Irritant
HazardClass: IRRITANT
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 540455
Product name: 3,4-Dimethylphenylhydrazine hydrochloride
Purity: 97%
Packaging: 25g
Price: $325
Updated: 2023/06/20

TCI Chemical

Product number: D3616
Product name: 3,4-Dimethylphenylhydrazine Hydrochloride
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: D3616
Product name: 3,4-Dimethylphenylhydrazine Hydrochloride
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $70
Updated: 2025/07/31

TRC

Product number: D457115
Product name: 3,4-DimethylphenylhydrazineHydrochlorideSalt
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D457115
Product name: 3,4-DimethylphenylhydrazineHydrochlorideSalt
Packaging: 250mg
Price: $50
Updated: 2021/12/16

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3,4-Dimethylphenylhydrazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to pink or beige-brown powder

Uses

3,4-Dimethylphenylhydrazine hydrochloride, is used as a reactant with ethyl 3-ethoxy-2-ethoxycarbonylprop-2-enoate to produce 2-(3,4-dimethyl-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester. This reaction will need reagent K2CO3, and the menstruum ethanol.

Synthesis

583-71-1

60481-51-8

General procedure for the synthesis of 3,4-dimethylphenylhydrazine hydrochloride from 4-bromo-1,2-xylene: in a 15 mL screw-top capped test tube, CuBr (36 mg, 0.25 mmol, 2.5 mol%), ligand L3 (110 mg, 0.4 mmol, 4 mol%), H2O (0.5 mL), and K3PO4 (254 mg, 1.2 mmol). STAC (110 mg, 0.3 mmol, 3 mol%) and aryl bromide (10 mmol) were then added and the reaction mixture was stirred at 80-110°C (oil bath temperature) for 10 minutes. Then K3PO4 (2.29 g, 10.8 mmol) and N2H4-H2O (1 g, 20 mmol) were added and argon gas (flow rate 5-7 mL/min) was bubbled through the reaction mixture for 5 minutes. The reaction mixture was stirred in a closed test tube at 80-110°C for 1-2 h. The progress of the reaction was monitored by TLC (eluent: hexane) until the feedstock was completely consumed. After completion of the reaction, it was cooled to room temperature and diluted with dichloromethane (50 mL). The reaction solution was filtered and the organic phase was washed with saturated saline (225 mL). A 37% aqueous HCl solution was added dropwise to the dichloromethane solution and the pH was adjusted to 3-4. The precipitate precipitated was filtered, washed with dichloromethane (15 mL) and dried at room temperature. NMR analysis of the partially synthesized arylhydrazine hydrochloride showed the presence of 1-5 mol% impurities of the corresponding aniline hydrochloride (see Supplementary Data). To obtain an analytically pure sample, the precipitate can be purified by adding 2-3 volumes of diethyl ether from a methanol solution.

References

[1] Chinese Journal of Chemistry, 2018, vol. 36, # 11, p. 1003 - 1006
[2] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048

3,4-Dimethylphenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dimethylphenylhydrazine hydrochloride Suppliers

Americas 1 Belgium 1 China 204 Europe 1 France 1 Germany 3 India 26 Japan 2 Switzerland 2 United Kingdom 7 United States 26 Global 274

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View Lastest Price from 3,4-Dimethylphenylhydrazine hydrochloride manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3,4-Dimethylphenylhydrazine hydrochloride 60481-51-8
Price: US $10.00-0.80/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-12

Career Henan Chemical Co

Product: 3,4-Dimethylphenylhydrazine hydrochloride 60481-51-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%HPLC
Supply Ability: 100KG
Release date: 2020-02-04

60481-51-8, 3,4-Dimethylphenylhydrazine hydrochlorideRelated Search:

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LABOTEST-BB LT01148173

3,4-DIMETHYLPHENYLHYDRAZINE HCL

3,4-DIMETHYLPHENYLHYDRAZINE HYDROCHLORID

1-(3,4-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE

3,4-Dimethylphenylhydrazine hydrochloride,98%

3,4-Dimethylphenylhydrazine hydrochloride

3,4-DIMETHYLPHENYLHYDRAZINE HYDOCHLORIDE

DiMethylphenylhydrazine hydrochlorid

4-Hydrazino-o-xylene hydrochloride

Hydrazine,(3,4-dimethylphenyl)-, hydrochloride (1:1)

3,4-Dimethylphenylhydrazine Hydrochloride &gt

3,4-Dimethylphenylhydrazine hydrochloride ISO 9001：2015 REACH

(3,4-dimethylphenyl)-Hydrazine hydrochloride (1:1)

3,4-Dimethylphenylhydrazine monohydrochloride

Eltrombopag Impurity 63 HCl

*Fenthion Impurity 18 (Temephos)

60481-51-8

C15H15Ce

Building Blocks

Hydrazines

Nitrogen Compounds

Organic Building Blocks

Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes

API intermediates

Hydrazines

Nitrogen Compounds

Organic Building Blocks