Uses
ChemicalBook > CAS DataBase List > PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE

PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE

Uses
Product Name
PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
CAS No.
159326-68-8
Chemical Name
PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
Synonyms
Pyrrolo[2,1-f][1,2,4]triazin-4-amine;Remdesivir-005;IFLAB-BB F2108-0125;Redesivir Impurity 5;Remdesivir Impurity 19;Pyrrolo[1,2-f][1,2,4]tria...;(starting material precursor);4-pyrrolo[2,1-f][1,2,4]triazinamine;Pyrrolo[2,1-f][1,2,4]triazin-4-aMin;PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMIN
CBNumber
CB5734489
Molecular Formula
C6H6N4
Formula Weight
134.14
MOL File
159326-68-8.mol
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PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Property

Melting point:
231°
Density 
1.50
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.28±0.30(Predicted)
form 
powder
color 
Light brown
InChI
InChI=1S/C6H6N4/c7-6-5-2-1-3-10(5)9-4-8-6/h1-4H,(H2,7,8,9)
InChIKey
VSPXQZSDPSOPRO-UHFFFAOYSA-N
SMILES
N12C=CC=C1C(N)=NC=N2
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
HS Code 
2933698090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
P3258
Product name
Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging
5G
Price
$74
Updated
2025/07/31
TCI Chemical
Product number
P3258
Product name
Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging
25G
Price
$222
Updated
2025/07/31
TRC
Product number
B525050
Product name
Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-W003471
Product name
Pyrrolo[1,2-f][1,2,4]triazin-4-amine
Purity
99.98%
Packaging
5g
Price
$57
Updated
2021/12/16
AK Scientific
Product number
Z2815
Product name
Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging
1g
Price
$94
Updated
2021/12/16
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PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Chemical Properties,Usage,Production

Uses

Pyrrolo[2,1-F][1,2,4]triazine-4-amine (an intermediate for remdesivir) is used in the synthesis of the drug remdesivir.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 31, p. 781, 1994 DOI: 10.1002/jhet.5570310415

Synthesis

937046-97-4

3473-63-0

159326-68-8

To a stirred suspension of 1-amino-1H-pyrrole-2-carbonitrile hydrochloride (50 g, 0.35 mol) in anhydrous ethanol (800 mL) was sequentially added formamidine acetate (181.3 g, 1.74 mol) and potassium phosphate (370 g, 1.74 mol). The reaction mixture was heated to 78 °C under nitrogen protection and maintained for 18 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was filtered and the filtrate was concentrated to dryness under vacuum. The residue was mixed with ice water (2 L) and the resulting dark gray-brown solid was collected by filtration. The filter cake was washed with water, blotted dry, the solid was dissolved in hot ethyl acetate and filtered over a funnel into a collection vessel. The resulting dark solution was filtered through a 30/40 Magnesol long stopper, and the light yellow filtrate was collected and concentrated to dryness under vacuum to give a yellow solid product (20.6 g, 44.1% yield). The Magnesol plug was washed with ethyl acetate/ethanol and the washings were concentrated under vacuum to give additional product (10.7 g, 23%). The aqueous phase filtrate was extracted with ethyl acetate and the organic phase was dried, Magnesol filtered and concentrated to give a further purified product (6.3 g, 14%), bringing the total yield to 37.6 g (81%). The product was characterized by 1H-NMR (CD3OD) and LC/MS (+ESI): 1H-NMR δ 7.72 (s, 1H), 7.52 (dd, 1H, J = 2.5, 1.6 Hz), 6.85 (dd, 1H, J = 4.5, 1.6 Hz), 6.64 (dd, 1H, J = 4.5, 2.7 Hz); LC/MS m/z = 135.1 [M + H].

References

[1] Patent: WO2007/56170, 2007, A2. Location in patent: Page/Page column 73-74
[2] Patent: WO2007/64931, 2007, A2. Location in patent: Page/Page column 163

PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Suppliers

Canada 1 China 302 France 1 Germany 1 India 22 Switzerland 1 Ukraine 1 United Kingdom 1 United States 20 Global 350
LIFE CHEMICALS, formerly I.F. Lab
Tel
--
Fax
--
Email
vasily.pinchuk@lifechemicals.com
Country
Canada
ProdList
6706
Advantage
69
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View Lastest Price from PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
pyrrolo[2,1-f][1,2,4]triazin-4-amine 159326-68-8
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min
Supply Ability
10 KGS
Release date
2021-06-10
Jinan Finer Chemical Co., Ltd
Product
Pyrrolo[2,1-f][1,2,4]triazin-4-amine 159326-68-8
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
99%
Supply Ability
20mt
Release date
2020-03-31
Henan Aochuang Chemical Co.,Ltd.
Product
Pyrrolo[2,1-f][1,2,4]triazin-4-amine 159326-68-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27

159326-68-8, PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINERelated Search:

3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one QRFINCSKCRZION-WSZWBAFRSA-N PZPATWACAAOHTJ-CGLOQUBRSA-N QISHTWCSIVFJBU-UHFFFAOYSA-N QNSWMJYOGMUVGO-REWXTUPXSA-N QSIBSYLVSFILGA-RHQRLBAQSA-N 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-bis-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 1,1,1-Trichlorotrifluoroethane 2,6-Di-tert-butyl-4-(dimethylaminomethyl)phenol F4 L-Phenylalanine Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl- PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE AC480 (BMS-599626) IFLAB-BB F2108-0121 7-Methylpyrrolo[1,2-f][1,2,4]triazin-4-amine PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE

  • PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
  • Pyrrolo[1,2-f][1,2,4]tria...
  • 4-AMino-pyrrolo[2,1-f][1,2,4]triazin
  • 4-AMinopyrrolo[2,1-f][1,2,4]triazine
  • Pyrrolo[2,1-f][1,2,4]triazin-4-aMin
  • 4-pyrrolo[2,1-f][1,2,4]triazinamine
  • IFLAB-BB F2108-0125
  • Pyrrolo[2,1-f][1,2,4]triazin-4-amine
  • Remdesivir-005
  • Pyrrolo[2,1-f][1,2,4]triazin-4-amine,4]triazine
  • (starting material precursor)
  • Remdesivir Impurity 19
  • Pyrrolido [2,1-F][1,2,4] triazine-4-amine
  • PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMIN
  • Pyrrolo[2,1-f][1,2,4]triazin-4-amine powder
  • Pyrrolo[2,1-F][1,2,4]triazine-4-amine
  • Remdesivir Intermediate 2 PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
  • Pyrrolo [1,2-f] [1,2,4] trizin-4-amine
  • 4- Hydroxy-2,5-Di(propan-2- yl) benzoic acid
  • Redesivir Impurity 5
  • pyrrolo[1,2-d][1,2,4]triazin-1-amine
  • Pyrolo[2,1-f][1,2,4]triazin-4-amine
  • 159326-68-8
  • 159326-68-6
  • 1
  • 159326-68-8