ChemicalBook > CAS DataBase List > PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE

PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE

Uses

Product Name: PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
CAS No.: 159326-68-8
Chemical Name: PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
Synonyms: Pyrrolo[2,1-f][1,2,4]triazin-4-amine;Remdesivir-005;IFLAB-BB F2108-0125;Redesivir Impurity 5;Remdesivir Impurity 19;Pyrrolo[1,2-f][1,2,4]tria...;(starting material precursor);4-pyrrolo[2,1-f][1,2,4]triazinamine;Pyrrolo[2,1-f][1,2,4]triazin-4-aMin;PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMIN
CBNumber: CB5734489
Molecular Formula: C6H6N4
Formula Weight: 134.14
MOL File: 159326-68-8.mol

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PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Property

Melting point:: 231°
Density: 1.50
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.28±0.30(Predicted)
form: powder
color: Light brown
InChI: InChI=1S/C6H6N4/c7-6-5-2-1-3-10(5)9-4-8-6/h1-4H,(H2,7,8,9)
InChIKey: VSPXQZSDPSOPRO-UHFFFAOYSA-N
SMILES: N12C=CC=C1C(N)=NC=N2

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HS Code: 2933698090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: P3258
Product name: Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging: 5G
Price: $74
Updated: 2025/07/31

TCI Chemical

Product number: P3258
Product name: Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging: 25G
Price: $222
Updated: 2025/07/31

TRC

Product number: B525050
Product name: Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W003471
Product name: Pyrrolo[1,2-f][1,2,4]triazin-4-amine
Purity: 99.98%
Packaging: 5g
Price: $57
Updated: 2021/12/16

AK Scientific

Product number: Z2815
Product name: Pyrrolo[2,1-f][1,2,4]triazin-4-amine
Packaging: 1g
Price: $94
Updated: 2021/12/16

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PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Chemical Properties,Usage,Production

Uses

Pyrrolo[2,1-F][1,2,4]triazine-4-amine (an intermediate for remdesivir) is used in the synthesis of the drug remdesivir.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 31, p. 781, 1994 DOI: 10.1002/jhet.5570310415

Synthesis

937046-97-4

3473-63-0

159326-68-8

To a stirred suspension of 1-amino-1H-pyrrole-2-carbonitrile hydrochloride (50 g, 0.35 mol) in anhydrous ethanol (800 mL) was sequentially added formamidine acetate (181.3 g, 1.74 mol) and potassium phosphate (370 g, 1.74 mol). The reaction mixture was heated to 78 °C under nitrogen protection and maintained for 18 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was filtered and the filtrate was concentrated to dryness under vacuum. The residue was mixed with ice water (2 L) and the resulting dark gray-brown solid was collected by filtration. The filter cake was washed with water, blotted dry, the solid was dissolved in hot ethyl acetate and filtered over a funnel into a collection vessel. The resulting dark solution was filtered through a 30/40 Magnesol long stopper, and the light yellow filtrate was collected and concentrated to dryness under vacuum to give a yellow solid product (20.6 g, 44.1% yield). The Magnesol plug was washed with ethyl acetate/ethanol and the washings were concentrated under vacuum to give additional product (10.7 g, 23%). The aqueous phase filtrate was extracted with ethyl acetate and the organic phase was dried, Magnesol filtered and concentrated to give a further purified product (6.3 g, 14%), bringing the total yield to 37.6 g (81%). The product was characterized by 1H-NMR (CD3OD) and LC/MS (+ESI): 1H-NMR δ 7.72 (s, 1H), 7.52 (dd, 1H, J = 2.5, 1.6 Hz), 6.85 (dd, 1H, J = 4.5, 1.6 Hz), 6.64 (dd, 1H, J = 4.5, 2.7 Hz); LC/MS m/z = 135.1 [M + H].

References

[1] Patent: WO2007/56170, 2007, A2. Location in patent: Page/Page column 73-74
[2] Patent: WO2007/64931, 2007, A2. Location in patent: Page/Page column 163

PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Suppliers

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View Lastest Price from PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: pyrrolo[2,1-f][1,2,4]triazin-4-amine 159326-68-8
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%min
Supply Ability: 10 KGS
Release date: 2021-06-10

Jinan Finer Chemical Co., Ltd

Product: Pyrrolo[2,1-f][1,2,4]triazin-4-amine 159326-68-8
Price: US $0.00/Kg/Drum
Min. Order: 1g
Purity: 99%
Supply Ability: 20mt
Release date: 2020-03-31

Henan Aochuang Chemical Co.,Ltd.

Product: Pyrrolo[2,1-f][1,2,4]triazin-4-amine 159326-68-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

159326-68-8, PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINERelated Search:

3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one QRFINCSKCRZION-WSZWBAFRSA-N PZPATWACAAOHTJ-CGLOQUBRSA-N QISHTWCSIVFJBU-UHFFFAOYSA-N QNSWMJYOGMUVGO-REWXTUPXSA-N QSIBSYLVSFILGA-RHQRLBAQSA-N 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-bis-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 1,1,1-Trichlorotrifluoroethane 2,6-Di-tert-butyl-4-(dimethylaminomethyl)phenol F4 L-Phenylalanine Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl- PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE AC480 (BMS-599626) IFLAB-BB F2108-0121 7-Methylpyrrolo[1,2-f][1,2,4]triazin-4-amine PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE

PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE

Pyrrolo[1,2-f][1,2,4]tria...

4-AMino-pyrrolo[2,1-f][1,2,4]triazin

4-AMinopyrrolo[2,1-f][1,2,4]triazine

Pyrrolo[2,1-f][1,2,4]triazin-4-aMin

4-pyrrolo[2,1-f][1,2,4]triazinamine

IFLAB-BB F2108-0125

Pyrrolo[2,1-f][1,2,4]triazin-4-amine

Remdesivir-005

Pyrrolo[2,1-f][1,2,4]triazin-4-amine,4]triazine

(starting material precursor)

Remdesivir Impurity 19

Pyrrolido [2,1-F][1,2,4] triazine-4-amine

PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMIN

Pyrrolo[2,1-f][1,2,4]triazin-4-amine powder

Pyrrolo[2,1-F][1,2,4]triazine-4-amine

Remdesivir Intermediate 2 PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE

Pyrrolo [1,2-f] [1,2,4] trizin-4-amine

4- Hydroxy-2,5-Di(propan-2- yl) benzoic acid

Redesivir Impurity 5

pyrrolo[1,2-d][1,2,4]triazin-1-amine

Pyrolo[2,1-f][1,2,4]triazin-4-amine

159326-68-8

159326-68-6

159326-68-8