Apramycin sulfate Property

EPA Substance Registry System

D-Streptamine, O-4-amino-4-deoxy-.alpha.- D-glucopyranosyl-(1.fwdarw. 8)-O-(8R)-2-amino-2,3,7-trideoxy- 7-(methylamino)-D-glycero-. alpha.-D-allo-octodialdo- 1,5:8,4-dipyranosyl-(1.fwdarw. 4)-2-deoxy-(41194-16-5)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Apramycin sulfate Chemical Properties,Usage,Production

Description

Apramycin was found in the culture broth of Streptomyces tenebrarius by Eli Lilly in 1967 as one of the eight components of the nebramycin complex. Apramycin is used in feed additives.

Chemical Properties

A yellow or yellow-brown powder, hygroscopic and easily soluble in water. Apramycin sulfate is an excellent drug for the prevention and treatment of bacterial diarrhea.

Uses

Apramycin sulfate has strong antibacterial activity against gram-negative bacteria and some gram-positive bacteria that are susceptible to infection in livestock and poultry, and can effectively prevent diarrhea caused by bacterial infection in livestock and poultry such as pigs, cattle and chickens , dysentery, dysplasia, etc..

Definition

ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol.

Mechanism of action

Aapramycin sulfate can interfere with the synthesis of prokaryotic riboprotein to inhibit harmful bacteria in animals. It is an aminocycloalcohol antibiotic, which has strong antibacterial activity against Gram-negative bacteria and some Gram-positive bacteria that are susceptible to infection in livestock and poultry, especially Escherichia coli and Salmonella that are resistant to other antibiotics Other pathogenic bacteria have quite strong antibacterial effect, and it is not easy to develop drug resistance.