3-Chloro-4-morpholino-1,2,5-thiadiazole

Product Name: 3-Chloro-4-morpholino-1,2,5-thiadiazole
CAS No.: 30165-96-9
Chemical Name: 3-Chloro-4-morpholino-1,2,5-thiadiazole
Synonyms: 4-(4-CHLORO-1,2,5-THIADIAZOL-3-YL)MORPHOLINE;Timolol EP Impurity F;AKOS BB-9733;AKOS B020558;ART-CHEM-BB B020558;TIMTEC-BB SBB000450;Timolol impurity F CRS;Timolol Related Compound F;Timolol Maleate Impurity F;(R)-(+)-Timolol maleate int
CBNumber: CB5749225
Molecular Formula: C6H8ClN3OS
Formula Weight: 205.67
MOL File: 30165-96-9.mol

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3-Chloro-4-morpholino-1,2,5-thiadiazole Property

Melting point:: 44-47 °C (lit.)
Boiling point:: 307.8±42.0 °C(Predicted)
Density: 1.462±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka: -0.18±0.10(Predicted)
form: Solid
color: White to Off-White
InChIKey: LAUCCQWGVCJGFT-UHFFFAOYSA-N
CAS DataBase Reference: 30165-96-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2594
Product name: Timolol Related Compound F
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $545.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 553786
Product name: 3-Chloro-4-morpholin-4-yl-1,2,5-thiadiazole
Purity: 98%
Packaging: 25g
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1667348
Product name: Timolol Related Compound F
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: C2189
Product name: 3-Chloro-4-morpholino-1,2,5-thiadiazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: C2189
Product name: 3-Chloro-4-morpholino-1,2,5-thiadiazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $68
Updated: 2025/07/31

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3-Chloro-4-morpholino-1,2,5-thiadiazole Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

3-Chloro-4-morpholino-1,2,5-thiadiazole (Timolol EP Impurity F; Timolol BP Impurity F; Timolol USP Related Compound F) is an intermediate for the synthesis of Timolol.

Synthesis

110-91-8

5728-20-1

30165-96-9

The general procedure for the synthesis of 3-chloro-4-morpholino-1,2,5-thiadiazole from morpholine and 3,4-dichloro-1,2,5-thiadiazole was as follows: morpholine (6.75 g, 77.4 mmol) was added to a 100-mL three-necked flask assembled with a reflux condenser tube. The flask was heated to 110 °C and 3,4-dichloro-1,2,5-thiadiazole (3.0 g, 19.3 mmol) was slowly added dropwise over 20 min. After the dropwise addition was completed, the reaction temperature was kept at 110°C with stirring for 2 hours. After completion of the reaction, the reaction mixture was cooled to 0°C in an ice bath. Water (30 mL) was added and the mixture was acidified with concentrated hydrochloric acid. The mixture was stirred at 0 °C until a precipitate precipitated. The solid product was collected by filtration, washed with water and dried. The resulting orange solid was recrystallized by methanol and dried under high vacuum to give 3.5 g (87.9% yield) of 4-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.45-3.55 (m, 2H), 3.80-3.90 (m, 2H). Mass spectral analysis showed (M + H)+ = 206.1.

References

[1] Synthesis, 2004, # 10, p. 1625 - 1628
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 14, p. 5281 - 5289
[3] ChemMedChem, 2015, vol. 10, # 2, p. 253 - 265
[4] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6641 - 6644
[5] Angew. Chem., 2014, p. 6759 - 6762,4

3-Chloro-4-morpholino-1,2,5-thiadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-morpholino-1,2,5-thiadiazole Suppliers

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View Lastest Price from 3-Chloro-4-morpholino-1,2,5-thiadiazole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Chloro-4-morpholino-1,2,5-thiadiazole 30165-96-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-26

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Chloro-4-morpholino-1,2,5-thiadiazole 30165-96-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-18

Hebei Zhanyao Biotechnology Co. Ltd

Product: 3-Chloro-4-morpholino-1,2,5-thiadiazole 30165-96-9
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-03

30165-96-9, 3-Chloro-4-morpholino-1,2,5-thiadiazoleRelated Search:

Moroxydine hydrochloride Dimethomorph Tridemorph Moroxydine Epichlorohydrin 2,1,3-Benzothiadiazole 2-Mercapto-5-methyl-1,3,4-thiadiazole TiMolol IMpurity E Timolol EP Impurity G Timolol Chloroacetic acid morpholine Difluorochloromethane 3-Chloro-4-morpholino-1,2,5-thiadiazole

3-MORPHOLINO-4-CHLORO-1,2,5-THIADIAZOLE

Timolol Related Compound F

4-(4-CHLORO-1,2,5-THIADIAZOL-3-YL)MORPHOLINE

3-Chloro-4-N-morpholine-1,2,5-thiadiazole

3-CHLORO-4-MORPHOLIN-4-YL-1,2,5-THIADIAZOLE

3-CHLORO-4-MORPHOLINO-1,2,5-THIADIAZOLE

3-CHLORO-4-MORPHOLINE-1,2,5-THIADIAZOLE

4-CHLORO-5-MORPHOLINO-2,1,3-THIADIAZOLE

4-CHLORO-3-MORPHOLINO-1,2,5-THIADIAZOLE

AKOS B020558

AKOS BB-9733

(R)-(+)-Timolol maleate int

Timolol Maleate EP Impurity F

Timolol Impurity 6（Timolol EP Impurity F）

Timolol EP Impurity F

ART-CHEM-BB B020558

TIMTEC-BB SBB000450

3-Morpholine-4-chloro-1,2,5-thiadiazole

3-Morpholine-4-chloro-1,2,5-th

3-Mor-4-chloro-1,2,5-thiadiazole

4-(4-Chloro-1,2,5-thiadiazol-3-yl)morpholine 97%

3-MORPHOLINE-4-CHLORO-1,2,5-THIADIAZOLE 99+%

3-Choro-4-morpholine-1,2,5-thiadiazole

4-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine(SALTDATA: FREE)

3-morpholine-4-chloro-1,2,5-thiazole

Morpholine,4-(4-chloro-1,2,5-thiadiazol-3-yl)-

3-Chloro-4-morpholin-4-yl-1,2,5-thiadiazole 98%

1,2,5-Thiadiazole, morpholine deriv.

3-Chloro-4-morpholino-1,2,5-thiadiazole(MCTD)

3-Chloro-4-morpholino-1,2,5-thiadiazole &gt

Timolol impurity F CRS

Timolol Impurity-F(3-chloro-4-morpholino-1,2,5-Thiadiazine)

Timolol EP Impurity F/ Timolol Related Compound F

Timolol impurity F (Y0001690)

Timolol Related Compound F (3-Chloro-4-morpholino-1,2,5-thiadiazol) (1667348)

3-Chloro-4-morphlino-1,2,5-thiadiazole

Timolol USP Related Compound F

3-Chloro-4-morpholino-1,2,5-thiadiazole with lowest price

Timolol Maleate Impurity F

3 Chloro 4 Morpholino,1,2,5Thiazole

3-Chloro-4-morpholino-1,2,5-thiadiazole, ≥ 98.0%

Timolol EP Impurity F (Timolol USP Related Compound F)

3-Morpholin-4-yl-4-chloro-1,2,5-thiadiazole

3-Chloro-4-morpholino-1,2,5-thiadiazol

30165-96-9

C6H8ClN3OS

Heterocyclic Building Blocks

Halogenated Heterocycles

Thiadiazoles

Building Blocks

Oxadiazoles & Thiadiazoles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiadiazoles

ThiadiazolesHeterocyclic Building Blocks

Heterocycles

Sulfur & Selenium Compounds