ChemicalBook > CAS DataBase List > 3-Chloro-4-morpholino-1,2,5-thiadiazole

3-Chloro-4-morpholino-1,2,5-thiadiazole

Product Name
3-Chloro-4-morpholino-1,2,5-thiadiazole
CAS No.
30165-96-9
Chemical Name
3-Chloro-4-morpholino-1,2,5-thiadiazole
Synonyms
4-(4-CHLORO-1,2,5-THIADIAZOL-3-YL)MORPHOLINE;Timolol EP Impurity F;AKOS BB-9733;AKOS B020558;ART-CHEM-BB B020558;TIMTEC-BB SBB000450;Timolol impurity F CRS;Timolol Related Compound F;Timolol Maleate Impurity F;(R)-(+)-Timolol maleate int
CBNumber
CB5749225
Molecular Formula
C6H8ClN3OS
Formula Weight
205.67
MOL File
30165-96-9.mol
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3-Chloro-4-morpholino-1,2,5-thiadiazole Property

Melting point:
44-47 °C (lit.)
Boiling point:
307.8±42.0 °C(Predicted)
Density 
1.462±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka
-0.18±0.10(Predicted)
form 
Solid
color 
White to Off-White
InChIKey
LAUCCQWGVCJGFT-UHFFFAOYSA-N
CAS DataBase Reference
30165-96-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2594
Product name
Timolol Related Compound F
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$545.3
Updated
2025/07/31
Sigma-Aldrich
Product number
553786
Product name
3-Chloro-4-morpholin-4-yl-1,2,5-thiadiazole
Purity
98%
Packaging
25g
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
1667348
Product name
Timolol Related Compound F
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1300
Updated
2025/07/31
TCI Chemical
Product number
C2189
Product name
3-Chloro-4-morpholino-1,2,5-thiadiazole
Purity
>98.0%(GC)
Packaging
5g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
C2189
Product name
3-Chloro-4-morpholino-1,2,5-thiadiazole
Purity
>98.0%(GC)
Packaging
25g
Price
$68
Updated
2025/07/31
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3-Chloro-4-morpholino-1,2,5-thiadiazole Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

3-Chloro-4-morpholino-1,2,5-thiadiazole (Timolol EP Impurity F; Timolol BP Impurity F; Timolol USP Related Compound F) is an intermediate for the synthesis of Timolol.

Synthesis

110-91-8

5728-20-1

30165-96-9

The general procedure for the synthesis of 3-chloro-4-morpholino-1,2,5-thiadiazole from morpholine and 3,4-dichloro-1,2,5-thiadiazole was as follows: morpholine (6.75 g, 77.4 mmol) was added to a 100-mL three-necked flask assembled with a reflux condenser tube. The flask was heated to 110 °C and 3,4-dichloro-1,2,5-thiadiazole (3.0 g, 19.3 mmol) was slowly added dropwise over 20 min. After the dropwise addition was completed, the reaction temperature was kept at 110°C with stirring for 2 hours. After completion of the reaction, the reaction mixture was cooled to 0°C in an ice bath. Water (30 mL) was added and the mixture was acidified with concentrated hydrochloric acid. The mixture was stirred at 0 °C until a precipitate precipitated. The solid product was collected by filtration, washed with water and dried. The resulting orange solid was recrystallized by methanol and dried under high vacuum to give 3.5 g (87.9% yield) of 4-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.45-3.55 (m, 2H), 3.80-3.90 (m, 2H). Mass spectral analysis showed (M + H)+ = 206.1.

References

[1] Synthesis, 2004, # 10, p. 1625 - 1628
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 14, p. 5281 - 5289
[3] ChemMedChem, 2015, vol. 10, # 2, p. 253 - 265
[4] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6641 - 6644
[5] Angew. Chem., 2014, p. 6759 - 6762,4

3-Chloro-4-morpholino-1,2,5-thiadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-morpholino-1,2,5-thiadiazole Suppliers

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View Lastest Price from 3-Chloro-4-morpholino-1,2,5-thiadiazole manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-Chloro-4-morpholino-1,2,5-thiadiazole 30165-96-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-26
Shaanxi Dideu Medichem Co. Ltd
Product
3-Chloro-4-morpholino-1,2,5-thiadiazole 30165-96-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-07-18
Hebei Zhanyao Biotechnology Co. Ltd
Product
3-Chloro-4-morpholino-1,2,5-thiadiazole 30165-96-9
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-03

30165-96-9, 3-Chloro-4-morpholino-1,2,5-thiadiazoleRelated Search:

Moroxydine hydrochloride Dimethomorph Tridemorph Moroxydine Epichlorohydrin 2,1,3-Benzothiadiazole 2-Mercapto-5-methyl-1,3,4-thiadiazole TiMolol IMpurity E Timolol EP Impurity G Timolol Chloroacetic acid morpholine Difluorochloromethane 3-Chloro-4-morpholino-1,2,5-thiadiazole

  • 3-MORPHOLINO-4-CHLORO-1,2,5-THIADIAZOLE
  • Timolol Related Compound F
  • 4-(4-CHLORO-1,2,5-THIADIAZOL-3-YL)MORPHOLINE
  • 3-Chloro-4-N-morpholine-1,2,5-thiadiazole
  • 3-CHLORO-4-MORPHOLIN-4-YL-1,2,5-THIADIAZOLE
  • 3-CHLORO-4-MORPHOLINO-1,2,5-THIADIAZOLE
  • 3-CHLORO-4-MORPHOLINE-1,2,5-THIADIAZOLE
  • 4-CHLORO-5-MORPHOLINO-2,1,3-THIADIAZOLE
  • 4-CHLORO-3-MORPHOLINO-1,2,5-THIADIAZOLE
  • AKOS B020558
  • AKOS BB-9733
  • (R)-(+)-Timolol maleate int
  • Timolol Maleate EP Impurity F
  • Timolol Impurity 6（Timolol EP Impurity F）
  • Timolol EP Impurity F
  • ART-CHEM-BB B020558
  • TIMTEC-BB SBB000450
  • 3-Morpholine-4-chloro-1,2,5-thiadiazole
  • 3-Morpholine-4-chloro-1,2,5-th
  • 3-Mor-4-chloro-1,2,5-thiadiazole
  • 4-(4-Chloro-1,2,5-thiadiazol-3-yl)morpholine 97%
  • 3-MORPHOLINE-4-CHLORO-1,2,5-THIADIAZOLE 99+%
  • 3-Choro-4-morpholine-1,2,5-thiadiazole
  • 4-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine(SALTDATA: FREE)
  • 3-morpholine-4-chloro-1,2,5-thiazole
  • Morpholine,4-(4-chloro-1,2,5-thiadiazol-3-yl)-
  • 3-Chloro-4-morpholin-4-yl-1,2,5-thiadiazole 98%
  • 1,2,5-Thiadiazole, morpholine deriv.
  • 3-Chloro-4-morpholino-1,2,5-thiadiazole(MCTD)
  • 3-Chloro-4-morpholino-1,2,5-thiadiazole &gt
  • Timolol impurity F CRS
  • Timolol Impurity-F(3-chloro-4-morpholino-1,2,5-Thiadiazine)
  • Timolol EP Impurity F/ Timolol Related Compound F
  • Timolol impurity F (Y0001690)
  • Timolol Related Compound F (3-Chloro-4-morpholino-1,2,5-thiadiazol) (1667348)
  • 3-Chloro-4-morphlino-1,2,5-thiadiazole
  • Timolol USP Related Compound F
  • 3-Chloro-4-morpholino-1,2,5-thiadiazole with lowest price
  • Timolol Maleate Impurity F
  • 3 Chloro 4 Morpholino,1,2,5Thiazole
  • 3-Chloro-4-morpholino-1,2,5-thiadiazole, ≥ 98.0%
  • Timolol EP Impurity F (Timolol USP Related Compound F)
  • 3-Morpholin-4-yl-4-chloro-1,2,5-thiadiazole
  • 3-Chloro-4-morpholino-1,2,5-thiadiazol
  • 30165-96-9
  • C6H8ClN3OS
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Thiadiazoles
  • Building Blocks
  • Oxadiazoles & Thiadiazoles
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Thiadiazoles
  • ThiadiazolesHeterocyclic Building Blocks
  • Heterocycles
  • Sulfur & Selenium Compounds