Pyridazine

ChemicalBook > CAS DataBase List > Pyridazine

Description Heterocyclic compound Synthesis and Structure

Product Name: Pyridazine
CAS No.: 289-80-5
Chemical Name: Pyridazine
Synonyms: diazine;Pyridazin;PYRENE-1-CARBALDEHYDE;OIZINE;Orizine;o-diazine;yridazine;PYRIDAZINE;AKOS 92457;1,2-DIAZINE
CBNumber: CB5752911
Molecular Formula: C4H4N2
Formula Weight: 80.09
MOL File: 289-80-5.mol

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Pyridazine Property

Melting point:: -8 °C (lit.)
Boiling point:: 208 °C (lit.)
Density: 1.103 g/mL at 25 °C (lit.)
refractive index: n20/D 1.524(lit.)
Flash point:: 185 °F
storage temp.: Inert atmosphere,Room Temperature
pka: 2.24(at 20℃)
form: Liquid
color: Clear yellow-brown
Water Solubility: MISCIBLE
Merck: 14,7969
BRN: 103906
InChIKey: PBMFSQRYOILNGV-UHFFFAOYSA-N
CAS DataBase Reference: 289-80-5(CAS DataBase Reference)
NIST Chemistry Reference: Pyridazine(289-80-5)
EPA Substance Registry System: Pyridazine (289-80-5)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 23-24/25
RIDADR: NA 1993 / PGIII
WGK Germany: 3
RTECS: UR5267000
F: 8-10
TSCA: Yes
HS Code: 29339980
Toxicity: LD50 ipr-mus: 2650 mg/kg PBPHAW 1,542,65

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P57204
Product name: Pyridazine
Purity: 98%
Packaging: 5g
Price: $73.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: P57204
Product name: Pyridazine
Purity: 98%
Packaging: 50g
Price: $550
Updated: 2024/03/01

TCI Chemical

Product number: P0616
Product name: Pyridazine
Purity: >99.0%(GC)
Packaging: 5g
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: P0616
Product name: Pyridazine
Purity: >99.0%(GC)
Packaging: 25g
Price: $137
Updated: 2024/03/01

Alfa Aesar

Product number: A13266
Product name: Pyridazine, 98+%
Packaging: 5g
Price: $46.65
Updated: 2024/03/01

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Pyridazine Chemical Properties,Usage,Production

Description

Pyridazine, sometimes called 1,2-diazine, is a six-membered ring containing two adjacent nitrogen atoms. Pyridazine is a privileged structure in medicinal chemistry and can be used as an isosteric replacement of phenyl or heteroaromatic rings. Pyridazines can improve the physiochemical properties of drug molecules by increasing their water solubility, participating as hydrogen bond acceptors, and have a high capacity to complex with targets due to their dipole moment. Pyridazine confers bioavailability, especially to the CNS, and can reduce toxicity. Pyridazine is a part of several drug molecules, and the pyradzine pharmacophore has led to a variety of pharmacologically active compounds.

Heterocyclic compound

Pyridazine refers to a heterocyclic azine compound containing a nitrogen hexaheterocyclic , it and pyrimidine, pyrazine are isomers of each other , it is insoluble in petroleum ether, soluble in methanol, ethanol and ether, and it can be miscible with water, benzene and dimethyl formamide immiscibility. Pyridazine is a weak base, which can form salts with picric acid, and hydrochloric acid; pyridazine is not prone to nucleophilic and electrophilic aromatic substitution reaction; it is stable to potassium permanganate; sodium or alcohols may be reduced open-chain , and converted to 1,4-diaminobutane. Pyridazine is widely used as pharmaceutical raw materials, such as long-term sulfa SMP which is pyridazine derivative, 4-amino-cinnoline which belongs to antimalarials, blood pressure drug hydralazine, etc. all use pyridazine as raw materials; it can also be used as raw material of pesticides, for the production of herbicides, "herbicide-sensitive", "Milstem", "bromine herbicide-sensitive", "Kusakira," "maleic hydrazide", "Norflurazon", "pyridate "" insecticide "," imputed phosphorus "and so on.

Synthesis and Structure

Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. The pyridazine molecule is a π-deficient heteroaromatic compound similar to pyridine. Due to the presence of the π-deficient nitrogen aromatic heterocycles these compounds are more easily soluble in water when compared to other hydrocarbons. The basic aromatic ring system of pyridazine contains two adjacent nitrogen atoms.
The parent heterocycle was first prepared by oxidation of benzocinnoline to the pyridazinetetracarboxylic acid followed by decarboxylation. A better route to this otherwise esoteric compound starts with the maleic hydrazide. These heterocycles are often prepared via condensation of 1,4-diketones or 4-ketoacids with hydrazines.
Pyridazines are effective water oxidation catalysts with high efficiency turnover numbers up to 700.

Chemical Properties

Clear yellowish-brown liquid

Uses

Pyrrolo[1,2-b]pyridazine 1 is a N-bridgehead aromatic heterocycle containing two nitrogen atoms, is obtained by the condensation of pyridazine and pyrrole.

Definition

ChEBI: Pyridazine is a member of pyridazines and a diazine.

General Description

Pyridazine is a mono-basic 1,2-diazine compound, which is commonly prepared by the reaction of 1,4-dicarbonyls with hydrazines. Pyridazine ring is found in many herbicides like credazine, pyridatol and many pharmaceutical drugs like cefozopran, olaparib, talazoparib, and cadralazine.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.

Pyridazine Preparation Products And Raw materials

Raw materials

Hydrazine hydrate 2,5-Dihydro-2,5-dimethoxyfuran

Preparation Products

Cefozopran Bazinaprine Pyridat Levosimendan

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View Lastest Price from Pyridazine manufacturers

Henan Fengda Chemical Co., Ltd

Product: Pyridazine 289-80-5
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: Pyridazine 289-80-5
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-08

Shaanxi Dideu Medichem Co. Ltd

Product: Pyridazine 289-80-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-04-29

289-80-5, PyridazineRelated Search:

Sulfamethoxypyridazine 3-Chloro-6-methylpyridazine 3,6-Dichloropyridazine ETHYL 4-PYRIDAZINECARBOXYLATE pyridazine-4-boronic acid pinacol ester 3-Pyridazinecarboxylic acid pyridazine-3-carbonitrile PYRIDAZINE-4-CARBALDEHYDE Pyridazine-4-carboxylic acid methyl ester 2-(TERT-BUTYL)-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE Pyridazin-3-ylmethanol 1,4-Dichlorophthalazine 3,6-Dichloro-4-methylpyridazine BENZO[C]CINNOLINE 1-CHLOROPHTHALAZINE Phthalazine SULFACHLOROPYRIDAZINE Simendan

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yridazine

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