2,2'-BIPYRIDINE-5-CARBOXYLIC ACID
- Product Name
- 2,2'-BIPYRIDINE-5-CARBOXYLIC ACID
- CAS No.
- 1970-80-5
- Chemical Name
- 2,2'-BIPYRIDINE-5-CARBOXYLIC ACID
- Synonyms
- DK7312;5-Carboxy-2,2'-bipyridine;5-Carboxy-2,2’-bipyridine;6-(2-pyridyl)nicotinic acid;2,2Bipyridyl-5-carboxylic acid;6-(Pyridin-2-yl)nicotinic acid;,2'-BIPYRIDINE-5-CARBOXYLIC ACID;2,2'-BIPYRIDINE-5-CARBOXYLIC ACID;BIPY443, 5-Carboxy-2,2'-bipyridine;2,2'-Bipyridine-5-carboxylic acid 95%
- CBNumber
- CB5755301
- Molecular Formula
- C11H8N2O2
- Formula Weight
- 200.19
- MOL File
- 1970-80-5.mol
2,2'-BIPYRIDINE-5-CARBOXYLIC ACID Property
- Melting point:
- 218-220 °C
- Boiling point:
- 405.5±35.0 °C(Predicted)
- Density
- 1.302±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- pka
- 2.44±0.10(Predicted)
- color
- White
- InChI
- InChI=1S/C11H8N2O2/c14-11(15)8-4-5-10(13-7-8)9-3-1-2-6-12-9/h1-7H,(H,14,15)
- InChIKey
- LWMHPOLRJIRLPN-UHFFFAOYSA-N
- SMILES
- C1(C2=NC=CC=C2)=NC=C(C(O)=O)C=C1
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B593618
- Product name
- 2,2''-Bipyridine-5-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W004554
- Product name
- 6-(Pyridin-2-yl)pyridine-3-carboxylicacid
- Purity
- 99.55%
- Packaging
- 250mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- CS-W004554
- Product name
- 6-(Pyridin-2-yl)pyridine-3-carboxylicacid
- Purity
- 99.55%
- Packaging
- 1g
- Price
- $274
- Updated
- 2021/12/16
- Product number
- OR18622
- Product name
- 2,2'-Bipyridine-5-carboxylicacid
- Purity
- 95%
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 4H21-1-0D
- Product name
- 2,2'-Bipyridine-5-carboxylic acid
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
2,2'-BIPYRIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Application
2,2'-BIPYRIDINE-5-CARBOXYLIC ACID is a useful research chemical.
Synthesis
58792-53-3
1970-80-5
General procedure for the synthesis of [2,2'-bipyridine]-5-carboxylic acid from methyl [2,2'-bipyridine]-5-carboxylate: first, 2-chloro-5-methoxycarbonylpyridine (1.3 g, 7.6 mmol) was dissolved in 20 ml of mesitylene, PdCl2(PPh3)2 (0.27 g, 0.04 mmol) and 2-trimethylpyridine (2.1 g, 8.6 mmol). The mixture was heated to reflux for 20 hours. After completion of the reaction, it was left to cool, diluted with ether and filtered through a neutral alumina column. The filtrate was washed several times with water and dried with anhydrous sodium sulfate. After evaporation of the solvent, it was purified by silica gel column chromatography to give 1.13 g of compound 10 as a white solid in 70% yield. Subsequently, compound 10 (1.13 g, 5.3 mmol) was suspended in 120 ml of ethanol/water mixed solvent in the ratio of 1:120 and a solution prepared by dissolving KOH (0.35 g, 6.3 mmol) in 2 ml of water was added and the reaction was stirred for 3 hours. After completion of the reaction, the ethanol was removed by distillation and concentration and adjusted to neutral by adding 1 mol/L hydrochloric acid. The resulting suspension was extracted three times with chloroform, the extract was washed with water, dried with anhydrous sodium sulfate and distilled to remove the solvent. The crude product was purified by silica gel column chromatography to afford 0.8 g of compound 11 as a light yellow solid in 75% yield.
References
[1] Organic Letters, 2007, vol. 9, # 26, p. 5333 - 5336
[2] Angewandte Chemie - International Edition, 2012, vol. 51, # 32, p. 8097 - 8100
[3] Tetrahedron, 2013, vol. 69, # 14, p. 3019 - 3026
[4] Journal of Organic Chemistry, 1999, vol. 64, # 3, p. 1015 - 1021
[5] Patent: JP6081152, 2017, B2. Location in patent: Paragraph 0015; 0037; 0038
2,2'-BIPYRIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2,2'-BIPYRIDINE-5-CARBOXYLIC ACID Suppliers
- Tel
- --
- Fax
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- synthon@synthon-chemicals.com
- Country
- Germany
- ProdList
- 2000
- Advantage
- 65
View Lastest Price from 2,2'-BIPYRIDINE-5-CARBOXYLIC ACID manufacturers
- Product
- ,2'-BIPYRIDINE-5-CARBOXYLIC ACID 1970-80-5
- Price
- US $3.00-9.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 50kg
- Release date
- 2025-07-28
- Product
- 2,2'-Bipyridine-5-carboxylic acid 1970-80-5
- Price
- US $50.00-449.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 10kg
- Release date
- 2024-10-25
- Product
- 2,2'-BIPYRIDINE-5-CARBOXYLIC ACID 1970-80-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27