N-Boc-3-carboethoxy-4-piperidone
Uses- Product Name
- N-Boc-3-carboethoxy-4-piperidone
- CAS No.
- 98977-34-5
- Chemical Name
- N-Boc-3-carboethoxy-4-piperidone
- Synonyms
- 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate;N-Boc-4-Oxo-3-piperidinecarboxylic acid ethyl ester;N-Boc-3-carboethoxy piperidone;4-oxopiperidine-1,3-dicarboxyL;N-Boc-3-Carboethxy-4-Piperidone;N-BOC-3-CARBETHOXY-4-PIPERIDONE;N-BOC-3-CARBOETHOXY-4-PIPERIDONE;N-T-BOC-3-CARBOETHOXY-4-PIPERIDONE;N-BOC-3-CARBOETHOXY-4-PIPERIDONE-C;1-Boc-3-ethoxycarbonyl-4-piperidone
- CBNumber
- CB5762671
- Molecular Formula
- C13H21NO5
- Formula Weight
- 271.31
- MOL File
- 98977-34-5.mol
N-Boc-3-carboethoxy-4-piperidone Property
- Melting point:
- 62.0 to 66.0 °C
- Boiling point:
- 364.6±42.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 11.08±0.20(Predicted)
- color
- White to Yellow
- InChI
- InChI=1S/C13H21NO5/c1-5-18-11(16)9-8-14(7-6-10(9)15)12(17)19-13(2,3)4/h9H,5-8H2,1-4H3
- InChIKey
- ABBVAMUCDQETDO-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(=O)C(C(OCC)=O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E0983
- Product name
- Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate
- Purity
- >97.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- E0983
- Product name
- Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate
- Purity
- >97.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $155
- Updated
- 2025/07/31
- Product number
- 239980
- Product name
- N-Boc-3-carboethoxy-4-piperidone
- Packaging
- 250mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- B701345
- Product name
- 1-tert-Butyl3-Ethyl4-Oxopiperidine-1,3-dicarboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 265708
- Product name
- N-Boc-3-carboethoxy-4-piperidone
- Packaging
- 500mg
- Price
- $382
- Updated
- 2021/12/16
N-Boc-3-carboethoxy-4-piperidone Chemical Properties,Usage,Production
Uses
1-N-Boc-4-oxo-3-piperidinecarboxylic acid ethyl ester is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Description
N-Boc-3-Carboethoxy-4-piperidone has several applications in scientific research. It is used as a biochemical reagent, a pharmaceutical intermediate, and a building block in organic synthesis. In biochemical research, N-Boc-3-Carboethoxy-4-piperidone can be a substrate for various enzymes, such as proteases and glycosidases. It can also be used as a starting material for synthesising various pharmaceuticals, such as antibiotics and anti-inflammatory drugs. Finally, it can be used as a building block in organic synthesis, as it can be used to synthesize various polymers and other organic compounds.
Synthesis
24424-99-5
1454-53-1
98977-34-5
Using ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride (10.0 g, 33.6 mmol) and ethanol (800 mL) as the reaction system, a Pd/C catalyst (1.0 g, 10% w/w) was added and the hydrogenation reaction was carried out for about 15 h at room temperature. Upon completion of the reaction, triethylamine (19 mL, 134.3 mmol) and di-tert-butyl dicarbonate (8.0 g, 36.9 mmol) were added to the system, and stirring was continued at room temperature for 16 hours. The reaction mixture was filtered through diatomaceous earth to remove the catalyst and the filtrate was concentrated under vacuum and the residue was dissolved in dichloromethane and washed with water for extraction. The organic phase was separated, dried with anhydrous sodium sulfate and concentrated again in vacuum to give the final ethyl 1-N-Boc-4-oxo-3-piperidinecarboxylate (Compound IB, 9.11 g, 100% yield).
References
[1] Patent: WO2008/130584, 2008, A1. Location in patent: Page/Page column 131; 135
[2] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1138 - 1148
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 13, p. 3970 - 3975
[4] Patent: WO2011/103091, 2011, A1. Location in patent: Page/Page column 93
N-Boc-3-carboethoxy-4-piperidone Preparation Products And Raw materials
Raw materials
Preparation Products
N-Boc-3-carboethoxy-4-piperidone Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from N-Boc-3-carboethoxy-4-piperidone manufacturers
- Product
- N-Boc-3-carboethoxy-4-piperidone 98977-34-5
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 100 Tons
- Release date
- 2025-09-25
- Product
- N-Boc-3-carboethoxy-4-piperidone 98977-34-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-31
- Product
- N-Boc-3-carboethoxy-4-piperidone 98977-34-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2019-08-05