ChemicalBook > CAS DataBase List > N-Boc-3-carboethoxy-4-piperidone

N-Boc-3-carboethoxy-4-piperidone

Uses

Product Name: N-Boc-3-carboethoxy-4-piperidone
CAS No.: 98977-34-5
Chemical Name: N-Boc-3-carboethoxy-4-piperidone
Synonyms: 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate;N-Boc-4-Oxo-3-piperidinecarboxylic acid ethyl ester;N-Boc-3-carboethoxy piperidone;4-oxopiperidine-1,3-dicarboxyL;N-Boc-3-Carboethxy-4-Piperidone;N-BOC-3-CARBETHOXY-4-PIPERIDONE;N-BOC-3-CARBOETHOXY-4-PIPERIDONE;N-T-BOC-3-CARBOETHOXY-4-PIPERIDONE;N-BOC-3-CARBOETHOXY-4-PIPERIDONE-C;1-Boc-3-ethoxycarbonyl-4-piperidone
CBNumber: CB5762671
Molecular Formula: C13H21NO5
Formula Weight: 271.31
MOL File: 98977-34-5.mol

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N-Boc-3-carboethoxy-4-piperidone Property

Melting point:: 62.0 to 66.0 °C
Boiling point:: 364.6±42.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 11.08±0.20(Predicted)
color: White to Yellow
InChI: InChI=1S/C13H21NO5/c1-5-18-11(16)9-8-14(7-6-10(9)15)12(17)19-13(2,3)4/h9H,5-8H2,1-4H3
InChIKey: ABBVAMUCDQETDO-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=O)C(C(OCC)=O)C1

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Safety

Risk Statements: 36/38
Safety Statements: 36
RIDADR: UN3259
HazardClass: 8
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E0983
Product name: Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate
Purity: >97.0%(HPLC)(N)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: E0983
Product name: Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate
Purity: >97.0%(HPLC)(N)
Packaging: 5g
Price: $155
Updated: 2025/07/31

Usbiological

Product number: 239980
Product name: N-Boc-3-carboethoxy-4-piperidone
Packaging: 250mg
Price: $245
Updated: 2021/12/16

TRC

Product number: B701345
Product name: 1-tert-Butyl3-Ethyl4-Oxopiperidine-1,3-dicarboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 265708
Product name: N-Boc-3-carboethoxy-4-piperidone
Packaging: 500mg
Price: $382
Updated: 2021/12/16

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N-Boc-3-carboethoxy-4-piperidone Chemical Properties,Usage,Production

Uses

1-N-Boc-4-oxo-3-piperidinecarboxylic acid ethyl ester is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Description

N-Boc-3-Carboethoxy-4-piperidone has several applications in scientific research. It is used as a biochemical reagent, a pharmaceutical intermediate, and a building block in organic synthesis. In biochemical research, N-Boc-3-Carboethoxy-4-piperidone can be a substrate for various enzymes, such as proteases and glycosidases. It can also be used as a starting material for synthesising various pharmaceuticals, such as antibiotics and anti-inflammatory drugs. Finally, it can be used as a building block in organic synthesis, as it can be used to synthesize various polymers and other organic compounds.

Synthesis

24424-99-5

1454-53-1

98977-34-5

Using ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride (10.0 g, 33.6 mmol) and ethanol (800 mL) as the reaction system, a Pd/C catalyst (1.0 g, 10% w/w) was added and the hydrogenation reaction was carried out for about 15 h at room temperature. Upon completion of the reaction, triethylamine (19 mL, 134.3 mmol) and di-tert-butyl dicarbonate (8.0 g, 36.9 mmol) were added to the system, and stirring was continued at room temperature for 16 hours. The reaction mixture was filtered through diatomaceous earth to remove the catalyst and the filtrate was concentrated under vacuum and the residue was dissolved in dichloromethane and washed with water for extraction. The organic phase was separated, dried with anhydrous sodium sulfate and concentrated again in vacuum to give the final ethyl 1-N-Boc-4-oxo-3-piperidinecarboxylate (Compound IB, 9.11 g, 100% yield).

References

[1] Patent: WO2008/130584, 2008, A1. Location in patent: Page/Page column 131; 135
[2] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1138 - 1148
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 13, p. 3970 - 3975
[4] Patent: WO2011/103091, 2011, A1. Location in patent: Page/Page column 93

N-Boc-3-carboethoxy-4-piperidone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-3-carboethoxy-4-piperidone manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: N-Boc-3-carboethoxy-4-piperidone 98977-34-5
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

Shaanxi Dideu New Materials Co. Ltd

Product: N-Boc-3-carboethoxy-4-piperidone 98977-34-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-31

Career Henan Chemical Co

Product: N-Boc-3-carboethoxy-4-piperidone 98977-34-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2019-08-05

98977-34-5, N-Boc-3-carboethoxy-4-piperidoneRelated Search:

Ethyl cellulose Ethylparaben DROPERIDOL Haloperidol Ethanol 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Ethyl acrylate Tris(trimethylsilyl)phosphate Buprofezin Methyl acrylate 2,2,6,6-Tetramethyl-4-piperidinol Ethylbenzene Ethyl acetate Butyl acetate N-Boc-piperidine-3-methanol 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Diethyl ether Carbonyl iron powder

Ethyl N-Boc-4-oxopiperidine-3-carboxylate

1-O-tert-butyl 3-O-ethyl 4-oxopiperidine-1,3-dicarboxylate

N-Boc-3-carboethoxy piperidone

Ethyl 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate

N-Boc-3-Carboethxy-4-Piperidone

1,3-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-ethyl ester

1-Tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate ethyl ester/N-Boc-3-carboethoxy-4-piperidone

1-tert-Butoxycarbonyl-3-(ethoxycarbonyl)piperidin-4-one

Ethyl 1-<i>tert</i>-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate

Ethyl 1-Boc-4-piperidone-3-carboxylate

4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER

1-N-BOC-4-OXO-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

N-BOC-3-CARBETHOXY-4-PIPERIDONE

N-BOC-3-CARBOETHOXY-4-PIPERIDONE

N-T-BOC-3-CARBOETHOXY-4-PIPERIDONE

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

1-Boc-4-oxo-3-piperidine carboxylic acid ethyl ester

Ethyl 1-(tert-butoxycarbonyl)-4-oxopiperidine-3-carboxylate, 1-tert-Butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

Ethyl 4-oxopiperidine-3-carboxylate, N-BOC protected

N-BOC-3-CARBOETHOXY-4-PIPERIDONE-C

4-Oxo-piperidine-1,3-dicarboxylic acid

Ethyl-N-Boc-4-piperidone-3-carboxylate

N-Boc-4-Oxo-3-piperidinecarboxylic acid ethyl ester

Ethyl 1-n-boc-4-oxo-3-piperidine carboxylate

Ethyl1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate&gt

4-oxopiperidine-1,3-dicarboxyL

1-Boc-3-ethoxycarbonyl-4-piperidone

1-tert-Butoxycarbonyl-3-ethoxycarbonyl-4-piperidone

1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylic Acid Ethyl Ester

Ethyl 1-Boc-4-oxo-3-piperidinecarboxylate

1-(1,1-Dimethylethyl) 3-ethyl 4-oxo-1,3-piperidinedicarboxylate

O1-tert-butyl O3-ethyl 4-oxopiperidine-1,3-dicarboxylate

N-Boc-3-carboethoxy-4-piperidone, 95%

N-Boc-3-Carboethoxy-4-Piperidone, CAS 98977-34-5

1-(tert-Butyl) 3-ethyl 4-oxo-1,3-piperidinedicarboxylate

98977-34-5

77-34-5

C13H21NO5

pharmacetical

API intermediates