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L-Hyoscyamine

Product Name
L-Hyoscyamine
CAS No.
101-31-5
Chemical Name
L-Hyoscyamine
Synonyms
HYOSCYAMINE;APOA;(-)-Hycosamine;AK38;L-(P);Levsin;SEPSECS;Levsinex;DATURINE;Cystospaz
CBNumber
CB5772230
Molecular Formula
C17H23NO3
Formula Weight
289.37
MOL File
101-31-5.mol
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L-Hyoscyamine Property

Melting point:
108,5°C
Boiling point:
431.53°C (rough estimate)
alpha 
D20 -21.0° (alc)
Density 
1.0470 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
2-8°C
solubility 
DMSO:79.0(Max Conc. mg/mL);273.0(Max Conc. mM)
Ethanol:58.0(Max Conc. mg/mL);200.43(Max Conc. mM)
form 
powder
pka
pKa (21°) 9.7
color 
white
Water Solubility 
3.6g/L(20 ºC)
Merck 
14,4858
InChIKey
RKUNBYITZUJHSG-FXUDXRNXSA-N
LogP
1.380 (est)
CAS DataBase Reference
101-31-5(CAS DataBase Reference)
NIST Chemistry Reference
Hyoscyamine(101-31-5)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)- (101-31-5)
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Safety

Hazard Codes 
T+
Risk Statements 
26/28
Safety Statements 
24-45
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
NH0875000
HazardClass 
6.1
PackingGroup 
I
HS Code 
29339900
Hazardous Substances Data
101-31-5(Hazardous Substances Data)
Toxicity
man,LDLo,unreported,1471ug/kg (1.471mg/kg),"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
HPA070409
Product name
Anti-SEPSECS antibody produced in rabbit
Purity
Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging
100μL
Price
$580
Updated
2024/03/01
Sigma-Aldrich
Product number
HPA070409
Product name
Anti-SEPSECS antibody produced in rabbit
Purity
Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging
25μL
Price
$282
Updated
2023/06/20
Cayman Chemical
Product number
25644
Product name
(?)-Hyoscyamine
Purity
≥98%
Packaging
250mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25644
Product name
(?)-Hyoscyamine
Purity
≥98%
Packaging
500mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
25644
Product name
(?)-Hyoscyamine
Purity
≥98%
Packaging
1g
Price
$87
Updated
2024/03/01
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L-Hyoscyamine Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Uses

L-Hyoscyamine can be used as anticholinergic and analgesic.

Uses

L-Hyoscyamine is a natural compound that has inhibitory activity against cholinesterases.

Definition

ChEBI: An atropine with a 2S-configuration.

General Description

Hyoscyamine is a levorotatory alkaloidobtained from various solanaceous species. One ofthe commercial sources is Egyptian henbane (Hyoscyamusmuticus), in which it occurs to the extent of about 0.5%.Usually, it is prepared from the crude drug in a manner similarto that used for atropine and is purified as the oxalate.The free base is obtained easily from this salt.
It occurs as white needles that are sparingly soluble inwater (1:281), more soluble in ether (1:69) or benzene(1:150), very soluble in chloroform (1:1), and freely solublein alcohol. It is used as the sulfate and hydrobromide. Theprincipal reason for the popularity of the hydrobromide hasbeen its nondeliquescent nature. The salts have the advantageover the free base in being quite water soluble.

Biochem/physiol Actions

The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).[supplied by OMIM]

Clinical Use

(L-Hyoscyamine)Hyoscyamine is used to treat disorders of the urinarytract more so than any other antispasmodic, although thereis no evidence that it has any advantages over the otherbelladonna preparations and the synthetic anticholinergics.It is used to treat spasms of the bladder and, in this manner,serves as a urinary stimulant. It is used together witha narcotic to counteract the spasm produced by the narcoticwhen the latter is used to relieve the pain of urethral colic.Hyoscyamine preparations are also used as antispasmodicsin the therapy of peptic ulcers.

target

AChR

L-Hyoscyamine Preparation Products And Raw materials

Raw materials

ExtracuM Belladonnae

Preparation Products

Atropine sulfate monohydrate
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L-Hyoscyamine Suppliers

Americas 1 Belgium 1 Brazil 1 Canada 1 China 170 Czech 1 Europe 2 France 2 Germany 5 India 13 Japan 3 South Korea 1 Switzerland 2 United Kingdom 3 United States 45 USA 1 Global 252
Melrob Ltd (part of Nordmann)
Tel
--
Fax
--
Email
nquiries@melrob.com
Country
United Kingdom
ProdList
3065
Advantage
58
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from L-Hyoscyamine manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Hyoscyamine 101-31-5
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
100 g
Release date
2020-08-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
L-Hyoscyamine 101-31-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
L-Hyoscyamine 101-31-5
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

101-31-5, L-HyoscyamineRelated Search:

Kresoxim-methyl Atropine Tribenuron methyl Atropine sulfate monohydrate METSULFURON METHYL ANISODAMINE Methyl salicylate Methyl acetate Scopolamine butylbromide Racanisodamine Atropine sulfate 3-(4-Hydroxyphenyl)propionic acid L(+)-Lactic acid Scopolamine hydrobromide Thiophanate-methyl CHLOROPHOSPHONAZO III HYOSCINE N BUTYL BROMIDE BP Methyl

  • (-)-hyoscyamin
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  • Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(S)-endo]-
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  • HYOSCYAMINEL
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  • [3(S)-endo]-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • [S,(-)]-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl
  • Alpha-(Hydroxymethyl)-Benzeneaceticaci8-Methyl-8-Azabicyclo[3.2.1]
  • HYOSCYAMINE, L-(P)
  • (-)-Hycosamine
  • (2S)-(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
  • (-)-tropicaciesterwithtropine
  • (3(s)-endo)-leste
  • (S)-(-)-Hyoscyamine
  • [3(s)-endo]-leste
  • 1-Hyoscyamine
  • alpha-(hydroxymethyl)-benzeneaceticaci8-methyl-8-azabicyclo(3.2.1)oct-3-y
  • alpha-(hydroxymethyl)-benzeneaceticaci8-methyl-8-azabicyclo[3.2.1]oct-3-y
  • Cystospaz
  • Duboisine
  • Hyocyamine
  • Levsin
  • Levsinex
  • l-Hyopscyamine
  • L-Hyoscamine
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  • L-HYOSCYAMINE
  • L-DATURINE
  • L-DUBOISINE
  • L-TROPINE TROPATE
  • DATURINE
  • (-)-HYOSCYAMINE
  • HYOSCYAMINE
  • BENZENEACETIC ACID, ALPHA-(HYDROXYMETHYL)-, 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, [3(S)-ENDO]
  • Benzeneacetic acid, a-(hydroxymethyl)-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (aS)-
  • (-)-Hyoscyamine, 97%, from Atropa belladonna L.
  • Anti-SEPSECS antibody produced in rabbit
  • DKFZp434B1417
  • MGC161491
  • SEPSECS
  • AK38
  • APOA
  • Monoclonal Anti-LPA antibody produced in mouse
  • Belladonna Liquid Extract/hyoscyamine
  • (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester
  • Hyoscamine