ChemicalBook > CAS DataBase List > 3,4-DIHYDROQUINOLIN-2(1H)-ONE

3,4-DIHYDROQUINOLIN-2(1H)-ONE

Product Name
3,4-DIHYDROQUINOLIN-2(1H)-ONE
CAS No.
553-03-7
Chemical Name
3,4-DIHYDROQUINOLIN-2(1H)-ONE
Synonyms
3,4-DIHYDRO-1H-QUINOLIN-2-ONE;HYDROCARBOSTYRIL;3,4-DIHYDRO-2(1H)-QUINOLINONE;inone;DIHYDROCARBOSTYRIL;dihydro-α-quinolone;3,4-Dihydrocarbostyril;3,4-Dihydro-2-quinolone;3,4-Dihydro-2(1H)-quinoL;3,4-Dihydro-2-quinolinone
CBNumber
CB5772351
Molecular Formula
C9H9NO
Formula Weight
147.17
MOL File
553-03-7.mol
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3,4-DIHYDROQUINOLIN-2(1H)-ONE Property

Melting point:
165-167 °C (lit.)
Boiling point:
267.28°C (rough estimate)
Density 
1.1135 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form 
Crystalline Powder
pka
14.76±0.20(Predicted)
color 
Off-white
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
Merck 
13,4800
CAS DataBase Reference
553-03-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36/37
RIDADR 
2811
WGK Germany 
2
Hazard Note 
Irritant
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
415936
Product name
3,4-Dihydro-2(1H)-quinolinone
Purity
98%
Packaging
10g
Price
$171
Updated
2023/06/20
Sigma-Aldrich
Product number
415936
Product name
3,4-Dihydro-2(1H)-quinolinone
Purity
98%
Packaging
1g
Price
$39.4
Updated
2023/01/07
Alfa Aesar
Product number
H36638
Product name
3,4-Dihydro-2-(1H)-quinolinone, 98%
Packaging
1g
Price
$42.65
Updated
2024/03/01
Alfa Aesar
Product number
H36638
Product name
3,4-Dihydro-2-(1H)-quinolinone, 98%
Packaging
5g
Price
$128.65
Updated
2024/03/01
Alfa Aesar
Product number
H36638
Product name
3,4-Dihydro-2-(1H)-quinolinone
Purity
98%
Packaging
25g
Price
$440
Updated
2021/12/16
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3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties,Usage,Production

Chemical Properties

Off-white crystalline powder

Uses

3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Uses

3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.

Definition

ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D

General Description

Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

3,4-DIHYDROQUINOLIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

Cilostazol VESNARINONE
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3,4-DIHYDROQUINOLIN-2(1H)-ONE Suppliers

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View Lastest Price from 3,4-DIHYDROQUINOLIN-2(1H)-ONE manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
1,2,3,4-Tetrahydroquinolin-2-one 553-03-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-14
Career Henan Chemical Co
Product
1,2,3,4-Tetrahydroquinolin-2-one 553-03-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-13

553-03-7, 3,4-DIHYDROQUINOLIN-2(1H)-ONERelated Search:

Tetrahydro-4H-pyran-4-one Naringin dihydrochalcone Isoquinoline Quinhydrone 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Epiandrosterone acetate Dehydroepiandrosterone Dihydromyrcenol Quinclorac 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE 3,4-DIHYDROQUINOLIN-2(1H)-ONE AURORA KA-3413 AURORA KA-6039 AURORA KA-5523 1-BUTYL-3-CHLORO-3-METHYL-1,2,3,4-TETRAHYDROQUINOLINE-2,4-DIONE 3-BENZYL-1-BUTYL-3-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE-2,4-DIONE AURORA KA-3185

  • HYDROCARBOSTYRIL
  • DIHYDROCARBOSTYRIL
  • 3,4-DIHYDRO-2(H)-QUINOLINE
  • 3,4-DIHYDRO-2(1H)-QUINOLINONE
  • 3,4-DIHYDRO-2(1H)-QUINOLONE
  • 3,4-DIHYDRO-1H-QUINOLIN-2-ONE
  • 1,2,3,4-Tetrahydroquinolin-2-one
  • 2-OXO-1,2,3,4-TETRAHYDROQUINOLINE
  • 2-OXO-1,3,4-TRIHYDROQUINOLINE
  • dihydro-α-quinolone
  • o-aminohydrocinnamic acid lactam
  • 3,4-Dihydrocarbostyril
  • 3,4-DIHYDRO-1H-QUINOLIN-2-ONE, 99+%
  • 2-Oxo-1,2,3,4-tetrahydroquinoline, 3,4-Dihydrocarbostyril
  • 3,4-Dihydroquinolin-2(1H)-one 97%
  • 4-Dihydro-2(1H)-quinolinone
  • 3,4-Dihydro-2-quinolone
  • 1,2,3,4-Tetrahydro-2(1H)-quinolinone
  • 1,2,3,4-Tetrahydro-2-oxoquinoline
  • 3,4-Dihydro-2-quinolinone
  • 1,2,3,4-Tetrahydroquinoline-2-one
  • 3,4-Dihydro-2(1H)-quinolinone,98%
  • 3,4-Dihydro-2(1H)-quinolinoneHydrocarbostyril
  • 2(1H)-Quinolinone, 3,4-dihydro-
  • 3,4-Dihydro-2(1H)-quinolinone, 97+%
  • 3,4-Dihydro-2(1H)-quinolinone 98%
  • 3,4-Dihydro-2(1H)-quinoL
  • inone
  • 1,2,3,4-Tetrahydroquinolin-2-one ISO 9001：2015 REACH
  • 4-Tetrahydroquinolin-2-one
  • 3,4-DIHYDROQUINOLIN-2(1H)-ONE
  • 553-03-7
  • C6H4CH2CH2CONH
  • Building Blocks
  • Quinolines
  • Heterocyclic Building Blocks
  • Quinolines, Isoquinolines & Quinoxalines
  • Heterocycles
  • pharmacetical
  • API intermediates