HYDROXYPIVALIC ACID METHYL ESTER

Uses

Product Name: HYDROXYPIVALIC ACID METHYL ESTER
CAS No.: 14002-80-3
Chemical Name: HYDROXYPIVALIC ACID METHYL ESTER
Synonyms: methyl 3-hydroxy-2,2-dimethylpropanoate;METHYL HYDROXYPIVALATE;METHYL 2,2-DIMETHYL-3-HYDROXYPROPIONATE;AI3-28360;methyl 3-hydroxypivalate;MethylHydroxypivalate>HYDROXYPIVALIC ACID METHYL ESTER;HYDROXY PIVALIC ACID METHYL ESTERS;Methyl 2,2-dimethyl-3-hydroxypropanoate;methyl 3-hydroxy-2,2-dimethyl-propanoate
CBNumber: CB5778267
Molecular Formula: C6H12O3
Formula Weight: 132.16
MOL File: 14002-80-3.mol

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HYDROXYPIVALIC ACID METHYL ESTER Property

Melting point:: -16 °C
Boiling point:: 177-178 °C740 mm Hg(lit.)
Density: 1.036 g/mL at 25 °C(lit.)
refractive index: n20/D 1.428(lit.)
Flash point:: 169 °F
storage temp.: Sealed in dry,Room Temperature
Water Solubility: Soluble in water
form: Liquid
pka: 14.21±0.10(Predicted)
color: Clear colorless
InChI: InChI=1S/C6H12O3/c1-6(2,4-7)5(8)9-3/h7H,4H2,1-3H3
InChIKey: KJRFTNVYOAGTHK-UHFFFAOYSA-N
SMILES: C(OC)(=O)C(C)(C)CO

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 227455
Product name: Methyl 2,2-dimethyl-3-hydroxypropionate
Purity: 98%
Packaging: 25g
Price: $78.8
Updated: 2023/01/07

TCI Chemical

Product number: H0906
Product name: Methyl Hydroxypivalate
Purity: >98.0%(GC)
Packaging: 25g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: H0906
Product name: Methyl Hydroxypivalate
Purity: >98.0%(GC)
Packaging: 500g
Price: $415
Updated: 2025/07/31

TRC

Product number: H950133
Product name: Hydroxypivalicacidmethylester
Packaging: 1g
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2129-1-42
Product name: Methyl 2,2-dimethyl-3-hydroxypropanoate
Purity: 98%
Packaging: 500g
Price: $560
Updated: 2021/12/16

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HYDROXYPIVALIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

HYDROXYPIVALIC ACID METHYL ESTER, also known as methyl 2,2-dimethyl-3-hydroxypropionate, methyl hydroxyneovalerate, or methyl hydroxypentanoate, is an important raw material for the synthesis of liquid crystal materials, pharmaceutical intermediates, and dyes. It is widely used in saturated polyester resins, polyurethanes, plasticizers, and other fields, serving as a high-grade raw material for the production of resins, paints, and coatings. It is also a crucial intermediate in the synthesis of the herbicide isoxaflutole.

Chemical Properties

Clear colorless liquid

Synthesis Reference(s)

Journal of the American Chemical Society, 85, p. 1460, 1963 DOI: 10.1021/ja00893a017

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 585, 1976 DOI: 10.1021/jo00865a049

General Description

Kinetics of decomposition of methyl 2,2-dimethyl-3-hydroxypropionate to methyl isobutyrate and formaldehyde in a static system has been investigated.

Synthesis

67-56-1

4835-90-9

14002-80-3

3-Hydroxy-2,2-dimethylpropionic acid (15.00 g, 127.0 mmol) was dissolved in methanol (200 mL), concentrated sulfuric acid (13.5 g, 254 mmol) was added, and the reaction was stirred under reflux conditions for 16 hours. After completion of the reaction, the reaction mixture was concentrated under vacuum, diluted with ethyl acetate (100 mL) and washed sequentially with water (2 x 50 mL), saturated aqueous sodium bicarbonate solution (50 mL), water (50 mL) and brine (50 mL). The organic phase was dried with anhydrous sodium sulfate and the organic solvent was subsequently removed under vacuum to afford methyl 3-hydroxy-2,2-dimethylpropionate (6.4 g, 57.2% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6) δ: 3.71 (s, 3H), 3.56 (s, 2H), 2.05-2.04 (m, 1H), 1.19 ( s, 6H).

References

[1] Patent: WO2014/145023, 2014, A1. Location in patent: Paragraph 0390
[2] Bulletin de la Societe Chimique de France, 1904, vol. <3>31, p. 129

HYDROXYPIVALIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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HYDROXYPIVALIC ACID METHYL ESTER Suppliers

Americas 1 Belgium 1 China 157 Europe 1 Germany 3 India 5 Japan 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 6 United States 21 Global 199

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View Lastest Price from HYDROXYPIVALIC ACID METHYL ESTER manufacturers

Honest Joy Holdings Limited

Product: Methyl 3-hydroxy-2,2-dimethylpropanoate 14002-80-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 100 tons
Release date: 2022-01-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: HYDROXYPIVALIC ACID METHYL ESTER 14002-80-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: HYDROXYPIVALIC ACID METHYL ESTER 14002-80-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

14002-80-3, HYDROXYPIVALIC ACID METHYL ESTERRelated Search:

DIETHYL DIALLYLMALONATE DIETHYL BIS(2-CYANOETHYL)MALONATE BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE DIETHYL DIMETHYLMALONATE Diethyl dipropylmalonate DIALLYL GLUTARATE Dimethyl diethylmalonate Diethyl bis(hydroxymethyl)malonate Diethyl dibutylmalonate HYDROXYPIVALIC ACID METHYL ESTER Diethyl 1,1-cyclobutanedicarboxylate DIETHYL DIETHYLMALONATE Diethyl 1,1-cyclopropanedicarboxylate Diethyl ethyl(isoamyl)malonate 3-Hydroxypropionic acid TETRAMETHYL 2,6-DIHYDROXYBICYCLO[3.3.1]NONA-2,6-DIENE-1,3,5,7-TETRACARBOXYLATE methyl 2,2-bis(hydroxymethyl)propionate DIETHYL METHYLPHENYLMALONATE

HYDROXYPIVALIC ACID METHYL ESTER

METHYL HYDROXYPIVALATE

METHYL 2,2-DIMETHYL-3-HYDROXYPROPIONATE

2,2-DIMETHYL-3-HYDROXYPROPIONIC ACID METHYL ESTER

methyl 3-hydroxypivalate

AI3-28360

HYDROXY PIVALIC ACID METHYL ESTERS

2,2-Dimethyl-3-hydroxypropanoic acid methyl ester

3-Hydroxy-2,2-dimethylpropionic acid methyl ester

Methyl 2,2-dimethyl-3-hydroxypropionate,98+%

methyl 3-hydroxy-2,2-dimethylpropanoate

methyl 3-hydroxy-2,2-dimethyl-propanoate

Methyl 2,2-dimethyl-3-hydroxypropanoate 98%

2,2-Dimethyl-3-hydroxypropionic Acid Methyl Ester Hydroxypivalic Acid Methyl Ester Methyl 2,2-Dimethyl-3-hydroxypropionate

Methyl 2,2-diMethyl-3-hydroxypropionate 98%

Methyl 2,2-dimethyl-3-hydroxypropanoate

Methyle2, 2-dimethyl-3-hydroxypropionate

Propanoic acid, 3-hydroxy-2,2-dimethyl-, methyl ester

MethylHydroxypivalate&gt

14002-80-3

HOCH2CCH32CO2CH3

ALCOHOL

Esters

Organic Building Blocks

Building Blocks

Carbonyl Compounds

C6 to C7

Carbonyl Compounds

Esters