ChemicalBook > CAS DataBase List > HYDROXYPIVALIC ACID METHYL ESTER
HYDROXYPIVALIC ACID METHYL ESTER
Uses- Product Name
- HYDROXYPIVALIC ACID METHYL ESTER
- CAS No.
- 14002-80-3
- Chemical Name
- HYDROXYPIVALIC ACID METHYL ESTER
- Synonyms
- methyl 3-hydroxy-2,2-dimethylpropanoate;METHYL HYDROXYPIVALATE;METHYL 2,2-DIMETHYL-3-HYDROXYPROPIONATE;AI3-28360;methyl 3-hydroxypivalate;MethylHydroxypivalate>HYDROXYPIVALIC ACID METHYL ESTER;HYDROXY PIVALIC ACID METHYL ESTERS;Methyl 2,2-dimethyl-3-hydroxypropanoate;methyl 3-hydroxy-2,2-dimethyl-propanoate
- CBNumber
- CB5778267
- Molecular Formula
- C6H12O3
- Formula Weight
- 132.16
- MOL File
- 14002-80-3.mol
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HYDROXYPIVALIC ACID METHYL ESTER Property
- Melting point:
- -16 °C
- Boiling point:
- 177-178 °C740 mm Hg(lit.)
- Density
- 1.036 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.428(lit.)
- Flash point:
- 169 °F
- storage temp.
- Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- Liquid
- pka
- 14.21±0.10(Predicted)
- color
- Clear colorless
- InChI
- InChI=1S/C6H12O3/c1-6(2,4-7)5(8)9-3/h7H,4H2,1-3H3
- InChIKey
- KJRFTNVYOAGTHK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C(C)(C)CO
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Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 29181990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 227455
- Product name
- Methyl 2,2-dimethyl-3-hydroxypropionate
- Purity
- 98%
- Packaging
- 25g
- Price
- $78.8
- Updated
- 2023/01/07
TCI Chemical
- Product number
- H0906
- Product name
- Methyl Hydroxypivalate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $51
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H0906
- Product name
- Methyl Hydroxypivalate
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $415
- Updated
- 2025/07/31
TRC
- Product number
- H950133
- Product name
- Hydroxypivalicacidmethylester
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2129-1-42
- Product name
- Methyl 2,2-dimethyl-3-hydroxypropanoate
- Purity
- 98%
- Packaging
- 500g
- Price
- $560
- Updated
- 2021/12/16
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HYDROXYPIVALIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
HYDROXYPIVALIC ACID METHYL ESTER, also known as methyl 2,2-dimethyl-3-hydroxypropionate, methyl hydroxyneovalerate, or methyl hydroxypentanoate, is an important raw material for the synthesis of liquid crystal materials, pharmaceutical intermediates, and dyes. It is widely used in saturated polyester resins, polyurethanes, plasticizers, and other fields, serving as a high-grade raw material for the production of resins, paints, and coatings. It is also a crucial intermediate in the synthesis of the herbicide isoxaflutole.
Chemical Properties
Clear colorless liquid
Synthesis Reference(s)
Journal of the American Chemical Society, 85, p. 1460, 1963 DOI: 10.1021/ja00893a017
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 585, 1976 DOI: 10.1021/jo00865a049
General Description
Kinetics of decomposition of methyl 2,2-dimethyl-3-hydroxypropionate to methyl isobutyrate and formaldehyde in a static system has been investigated.
Synthesis
67-56-1
4835-90-9
14002-80-3
3-Hydroxy-2,2-dimethylpropionic acid (15.00 g, 127.0 mmol) was dissolved in methanol (200 mL), concentrated sulfuric acid (13.5 g, 254 mmol) was added, and the reaction was stirred under reflux conditions for 16 hours. After completion of the reaction, the reaction mixture was concentrated under vacuum, diluted with ethyl acetate (100 mL) and washed sequentially with water (2 x 50 mL), saturated aqueous sodium bicarbonate solution (50 mL), water (50 mL) and brine (50 mL). The organic phase was dried with anhydrous sodium sulfate and the organic solvent was subsequently removed under vacuum to afford methyl 3-hydroxy-2,2-dimethylpropionate (6.4 g, 57.2% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6) δ: 3.71 (s, 3H), 3.56 (s, 2H), 2.05-2.04 (m, 1H), 1.19 ( s, 6H).
References
[1] Patent: WO2014/145023, 2014, A1. Location in patent: Paragraph 0390
[2] Bulletin de la Societe Chimique de France, 1904, vol. <3>31, p. 129
HYDROXYPIVALIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from HYDROXYPIVALIC ACID METHYL ESTER manufacturers
Honest Joy Holdings Limited
- Product
- Methyl 3-hydroxy-2,2-dimethylpropanoate 14002-80-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- HYDROXYPIVALIC ACID METHYL ESTER 14002-80-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- HYDROXYPIVALIC ACID METHYL ESTER 14002-80-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
14002-80-3, HYDROXYPIVALIC ACID METHYL ESTERRelated Search:
DIETHYL DIALLYLMALONATE
DIETHYL BIS(2-CYANOETHYL)MALONATE
BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE
DIETHYL DIMETHYLMALONATE
Diethyl dipropylmalonate
DIALLYL GLUTARATE
Dimethyl diethylmalonate
Diethyl bis(hydroxymethyl)malonate
Diethyl dibutylmalonate
HYDROXYPIVALIC ACID METHYL ESTER
Diethyl 1,1-cyclobutanedicarboxylate
DIETHYL DIETHYLMALONATE
Diethyl 1,1-cyclopropanedicarboxylate
Diethyl ethyl(isoamyl)malonate
3-Hydroxypropionic acid
TETRAMETHYL 2,6-DIHYDROXYBICYCLO[3.3.1]NONA-2,6-DIENE-1,3,5,7-TETRACARBOXYLATE
methyl 2,2-bis(hydroxymethyl)propionate
DIETHYL METHYLPHENYLMALONATE