Diethyl 1,1-cyclopropanedicarboxylate

Product Name: Diethyl 1,1-cyclopropanedicarboxylate
CAS No.: 1559-02-0
Chemical Name: Diethyl 1,1-cyclopropanedicarboxylate
Synonyms: DIETHYL CYCLOPROPANE-1,1-DICARBOXYLATE;1,1-CYCLOPROPANEDICARBOXYLIC ACID DIETHYL ESTER;Diethyl 1;NSC 21376;RARECHEM AL BO 0836;opropane-1,1-dicarboxyL;DiethyldifluoroMalonate96%;1-Cyclopropanedicarboxylate;1,1-Dicarbethoxycyclopropane;Ethyl 1,1-cyclopropanedicarboxylate
CBNumber: CB8853145
Molecular Formula: C9H14O4
Formula Weight: 186.21
MOL File: 1559-02-0.mol

More

Less

Diethyl 1,1-cyclopropanedicarboxylate Property

Melting point:: 134-136 °C(lit.)
Boiling point:: 94-96 °C/10 mmHg (lit.)
Density: 1.055 g/mL at 25 °C (lit.)
refractive index: n20/D 1.433(lit.)
Flash point:: 188 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Acetone (Slightly), Chlorform (Slightly), Methanol (Slightly)
form: Liquid
color: Clear colorless
BRN: 2049509
CAS DataBase Reference: 1559-02-0(CAS DataBase Reference)
NIST Chemistry Reference: Diethyl 1,1-cyclopropanedicarboxylate(1559-02-0)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25-23
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29172090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 147710
Product name: Diethyl cyclopropane-1,1-dicarboxylate
Purity: 97%
Packaging: 5g
Price: $103
Updated: 2023/06/20

Sigma-Aldrich

Product number: 147710
Product name: Diethyl cyclopropane-1,1-dicarboxylate
Purity: 97%
Packaging: 25g
Price: $381
Updated: 2023/06/20

TCI Chemical

Product number: C1341
Product name: Diethyl 1,1-Cyclopropanedicarboxylate
Purity: >96.0%(GC)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: C1341
Product name: Diethyl 1,1-Cyclopropanedicarboxylate
Purity: >96.0%(GC)
Packaging: 25g
Price: $33
Updated: 2025/07/31

TRC

Product number: D444175
Product name: Diethyl 1,1-Cyclopropanedicarboxylate
Packaging: 1g
Price: $55
Updated: 2021/12/16

More

Less

Diethyl 1,1-cyclopropanedicarboxylate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Diethyl 1,1-Cyclopropanedicarboxylate (cas# 1559-02-0) is a compound useful in organic synthesis.

Synthesis Reference(s)

Synthesis, p. 690, 1980 DOI: 10.1055/s-1980-29171

General Description

Diethyl cyclopropane-1,1-dicarboxylate participates in ring-opening addition reactions with various nucleophilic reagents.

Synthesis

106-93-4

105-53-3

1559-02-0

Step 1: Diethyl malonate (300 g, 1.87 mol) and 1,2-dibromoethane (634.5 g, 3.38 mol) were dissolved in DMSO (1.5 L) in a 5 L four-necked round bottom flask. To this solution was added K2CO3 (1020 g, 7.39 mol) and Bu4NBr (6.4 g, 19 mmol). The reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the reaction was quenched by adding 2 L of water and extracted with EtOAc (1.5 L, 3 times). The organic phases were combined, dried with Na2SO4 and concentrated under reduced pressure. The residue was distilled under vacuum at 5-10 mmHg at 64-65°C to give diethyl cyclopropane-1,1-dicarboxylate 400 g (90% yield) as an oil.

Purification Methods

If it is free from OH bands in the IR, then fractionally distil the ester and redistil the middle fraction. Otherwise shake it with aqueous NaHCO3, dry it (MgSO4), filter and distil as before or re-esterify it. [As synthon see Danishefsky Acc Chem Res 12 66 1979, Beilstein 9 I 314, 9 II 512, 9 III 3595, 9 IV 2786.]

References

[1] Tetrahedron, 2010, vol. 66, # 51, p. 9733 - 9737
[2] Tetrahedron Letters, 2005, vol. 46, # 4, p. 635 - 638
[3] Journal of Fluorine Chemistry, 2000, vol. 102, # 1-2, p. 141 - 146
[4] Mendeleev Communications, 2014, vol. 24, # 6, p. 345 - 345
[5] Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, p. 474 - 480

Diethyl 1,1-cyclopropanedicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

(1-Aminocyclopropyl)methanol

More

Less

Diethyl 1,1-cyclopropanedicarboxylate Suppliers

Americas 1 Belgium 2 Canada 3 China 253 Europe 4 France 5 Germany 10 India 34 Japan 5 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 13 United States 39 Global 377

Jinan Kabotang Biological Technology Co.,Ltd.

Tel: 0531-61320525 15866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 5178
Advantage: 58

Creasyn Finechem(Tianjin) Co., Ltd.

Tel: 022-83946278 13820503911
Fax: 022-83945176
Email: sales@creasyn.com
Country: China
ProdList: 958
Advantage: 68

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

More

Less

View Lastest Price from Diethyl 1,1-cyclopropanedicarboxylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Diethyl 1,1-cyclopropanedicarboxylate 1559-02-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Henan Aochuang Chemical Co.,Ltd.

Product: Diethyl 1,1-cyclopropanedicarboxylate 1559-02-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Diethyl 1,1-cyclopropanedicarboxylate 1559-02-0
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-14

1559-02-0, Diethyl 1,1-cyclopropanedicarboxylateRelated Search:

Diethyl malonate 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid Diethyl sulfate Diethyl phosphite Diethyl carbonate Diethyl oxalate Diethyl 1,3-acetonedicarboxylate Mefenpyr-diethyl Diethyl phthalate Cyclopropyl methyl ketone Ethylene glycol diethyl ether Celiprolol n-propyl dioxepene 1,1-Cyclopropanedicarboxylic acid Cyclopropane Diethyl ether DIETHYL 2-PHENYL-1,1-CYCLOPROPANEDICARBOXYLATE 2-VINYLCYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER

1,1-CYCLOPROPANEDICARBOXYLIC ACID DIETHYL ESTER

RARECHEM AL BO 0836

CYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER

DIETHYL 1,1-CYCLOPROPANEDICARBOXYLATE

DIETHYL CYCLOPROPANE-1,1-DICARBOXYLATE

DIETHYL 1,1-CYCLOPROPANEDICARBOXYLATE, 9 7%

DiethyldifluoroMalonate96%

1,1-Bis(ethoxycarbonyl)cyclopropane

Ethyl 1,1-cyclopropanedicarboxylate

DIETHYL 1,1-CYCLOPROPANE-DICARBONYLATE

1,1-Cyclopropanedicarboxylic acid, 1,1-diethyl ester

Diethyl 1,1-cyclopropanedicarboxylate ,99%

Diethyl 1,1-cyclopropane dicarboxyliate

1-Cyclopropanedicarboxylate

Diethyl 1

Diethyl 1,1-cyclopropanedicarboxylate, 97% 25GR

1,1-Dicarbethoxycyclopropane

NSC 21376

1, 1 - cyclopropyl dicarboxylic acid diethyl ester

Diethyl 1,1-Cyclopropanedicarboxylate &gt

opropane-1,1-dicarboxyL

DIETHYL 1,1-CYCLOPROPANEDICARBOXYLATE CAS 1559-02-0

TIANFU CHEM -- Diethyl 1,1-cyclopropanedicarboxylate

Diethylcyclopropan-1,1-dicarboxylat

Diethyl Cyclopropane-1,1-Dcarboxylate

Diethyl 1,1-cyclopropyl dicarboxylic acid

1559-02-0

C9H14O4

C3H4CO2C2H52

C1 to C5

C8 to C9

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Esters

Organic Building Blocks

Simple 3-Membered Ring Compounds

Cyclopropanes

Building Blocks

C8 to C9

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aliphatics

Cyclopropanes

Simple 3-Membered Ring Compounds

Cycloalkanes

C8 to C9

Carbonyl Compounds

Esters

bc0001