Rosmantuzumab

Product Name: Rosmantuzumab
CAS No.: 1684393-04-1
Chemical Name: Rosmantuzumab
Synonyms: OMP-131R10;Rosmantuzumab;Rosmantuzumab (anti-RSPO3);Research Grade Rosmantuzumab;Research Grade Rosmantuzumab (DHJ51101)
CBNumber: CB58081006
Formula Weight: 0
MOL File: Mol file

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Rosmantuzumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Rosmantuzumab Chemical Properties,Usage,Production

Uses

Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors[1].

in vivo

Rosmantuzumab (25 mg/kg; i.p., once a week for 4 weeks) significantly protects the animals from developing liver fibrosis^[1]. Rosmantuzumab (25 mg/kg; i.p., once for two weeks, for total 6 weeks) significantly inhibits skin thickness, collagen deposition, and number of α-SMA positive cells in bleomycin-induced lung fibrosis mouse models^[1].

Animal Model:	Male C57B1/6J CCl4 liver fibrosis mouse models^[1]
Dosage:	25 mg/kg
Administration:	Intraperitoneal injection; 25 mg/kg, once a week for 4 weeks
Result:	Significantly decreased collagen I and collagen III mRNAs, and inhibits β-catenin cytoplasmic and nuclear translocation.

References

[1] Zhang M, et al. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445. DOI:10.1371/journal.pone.0229445

Rosmantuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Rosmantuzumab Suppliers

China 22 United States 1 Global 23

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Rosmantuzumab

Research Grade Rosmantuzumab (DHJ51101)

Rosmantuzumab (anti-RSPO3)

OMP-131R10

Research Grade Rosmantuzumab

1684393-04-1