ChemicalBook > CAS DataBase List > 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

Product Name
1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
CAS No.
10394-38-4
Chemical Name
1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
Synonyms
NSC 240760;1-Methylbenzimidazol-5-amine;5-Amino-1-methylbenzimidazole;1-Methylbenzoimidazol-5-amine;1-Methyl-5-aminobenzimidazole;1-methylbenzimidazole-5-amine;1-methyl-1H-benzimidazol-5-amine;5-Amino-1-methyl-1H-benzimidazole;5-Amino-1-methylbenzimidazole,97%;1-Methyl-1H-1,3-benzodiazol-5-aMine
CBNumber
CB5835122
Molecular Formula
C8H9N3
Formula Weight
147.18
MOL File
10394-38-4.mol
More
Less

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Property

Melting point:
158-159 °C
Boiling point:
348.6±34.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Solid
pka
6.35±0.10(Predicted)
Appearance
Light brown to black Solid
More
Less

Safety

Risk Statements 
41
Safety Statements 
26-39
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Apolloscientific
Product number
OR301135
Product name
5-Amino-1-methyl-1H-benzimidazole
Packaging
250mg
Price
$56
Updated
2021/12/16
Matrix Scientific
Product number
076429
Product name
1-Methylbenzoimidazol-5-amine
Purity
95+%
Packaging
250mg
Price
$278
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-35
Product name
1-Methylbenzoimidazol-5-amine
Purity
95%
Packaging
1g
Price
$164
Updated
2021/12/16
AK Scientific
Product number
X8683
Product name
1-Methyl-1H-benzo[d]imidazol-5-amine
Packaging
1g
Price
$170
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-35
Product name
1-Methylbenzoimidazol-5-amine
Purity
95%
Packaging
250mg
Price
$66
Updated
2021/12/16
More
Less

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

1-Methyl-5-aminobenzimidazole is used in the synthesis of usnic acid derivatives as tau-aggregation and neuroinflammation inhibitor.

Synthesis

5381-78-2

10394-38-4

Example B23: 1-methyl-5-nitro-1H-benzo[d]imidazole (prepared according to the method described in WO 2005/092899; 1.14 g, 6.43 mmol) was dissolved in ethanol (50 ml) and stirred at room temperature under hydrogen (1 atm) atmosphere. 10% Pd/C catalyst (50 wt% water, 1.37 g, 0.643 mmol) was added. After 18 h of reaction, the reaction mixture was filtered through diatomaceous earth and rinsed with ethanol. The filtrates were combined and concentrated to afford the crude product 1-methyl-1H-benzo[d]imidazol-5-amine (1.02 g, 108% yield) as a dark orange oil, which was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6) δ 7.87 (s, 1H), 7.17 (d, J=8.4 Hz, 1H), 6.75 (d, J=2.0 Hz, 1H), 6.59 (dd, J=2.0 and 8.4 Hz, 1H), 4.73 (brs, 2H), 3.69 (s, 3H); MS (ESI) m/z: 148.0 (M+H+). Using a method similar to Example B22, 1-methyl-1H-benzo[d]imidazol-5-amine (0.50 g, 3.4 mmol), NaNO2 (0.28 g, 4.1 mmol), SnCl2-2H2O (2.8 g, 14 mmol), and 4-methyl-3-oxopentanenitrile (0.45 g, 4.1 mmol) were reacted to give the crude product 3-Isopropyl-1-(1-methyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-5-amine (0.63 g, 73% yield), as a foam, was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6): δ 8.22 (s, 1H), 7.72 (dd, J=0.40 and 1.2 Hz, 1H), and 7.60 (dd, J=0.40 and 8.4 Hz, 1H), 7.42 (dd, J=2.0 and 8.4 Hz, 1H), 5.32 (s, 1H), 5.08 (brs, 2H), 3.85 (s, 3H), 2.75 (septet, J=6.8 Hz, 1H), 1.16 (d, J=6.8 Hz, 6H); MS ( ESI) m/z: 250.0 (M+H+).

References

[1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 46-47
[2] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 20
[3] Journal of Pharmacy and Pharmacology, 1951, vol. 3, p. 420,424
[4] Gazzetta Chimica Italiana, 1955, vol. 85, p. 981,984
[5] Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 3, p. 713 - 724

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Suppliers

China 79 Europe 1 India 4 United Kingdom 1 United States 7 Global 92
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
More
Less

View Lastest Price from 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE 10394-38-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

10394-38-4, 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDERelated Search:

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Clonitazene etonitazene Bendamustine hydrochloride Bendamustine 1H-BENZOIMIDAZOL-5-YLAMINE 1H-Benzimidazole,1-methyl-5-nitro-(9CI) BIO-FARMA BF002412 CHEMBRDG-BB 5663117 1-ETHYL-2-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE 1-BENZYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE (1,2-DIMETHYL-1H-BENZOIMIDAZOL-5-YL)-(4-ETHOXY-BENZYL)-AMINE 2-ACETYL-3-([1-(4-CHLOROPHENYL)-1H-BENZIMIDAZOL-5-YL]AMINO)ACRYLONITRILE 1-(4-METHOXY-BENZYL)-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE 4-(5-AMINO-BENZOIMIDAZOL-1-YL)-BUTAN-1-OL 2-(3-(1,3-DIETHYL-5-NITRO-1H-2(3H)-BENZIMIDAZOLIDENE)-1-PROPENYL)-1,3-DIETHYL-5-NITRO-1H-BENZIMIDAZOLIUM 4-TOLUENESULFONATE N-{4-[5-(ACETYLAMINO)-1-PHENYL-1H-BENZIMIDAZOL-2-YL]PHENYL}ACETAMIDE 1-Ethyl-2-methyl-1H-benzoimidazol-5-ylaminedihydrochloride

  • 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
  • 1H-Benzimidazol-5-amine,1-methyl-(9CI)
  • 1-methyl-1H-benzimidazol-5-amine
  • 1-Methylbenzoimidazol-5-amine
  • 1-methyl-1H-benzimidazol-5-amine hydrochloride
  • 1-methyl-1H-benzimidazol-5-amine(SALTDATA: FREE)
  • 1-Methyl-1H-benzo[d]iMidazol-5-aMine
  • 1-Methyl-1H-1,3-benzodiazol-5-aMine
  • 1-Methyl-1H-benzo[d]iMidazol-5-YaMine
  • 5-Amino-1-methyl-1H-benzimidazole
  • 5-Amino-1-methylbenzimidazole
  • NSC 240760
  • 1-Methyl-5-aminobenzimidazole
  • 1H-Benzimidazol-5-amine, 1-methyl-, 95%
  • 1-methyl-5-benzimidazolamine trihydrochloride
  • 1-Methylbenzimidazol-5-amine
  • 5-Amino-1-methylbenzimidazole,97%
  • 1-methylbenzimidazole-5-amine
  • 10394-38-4
  • amine
  • BENZIMIDAZOLE