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Atractylenolide-1

Product Name
Atractylenolide-1
CAS No.
73069-13-3
Chemical Name
Atractylenolide-1
Synonyms
Extracted oil;Dictyolactone I;Atracylenolide I;Atractylenolide Ⅰ;ATRACTYLENOLIDE-1;Atractylenolide I-RM;8,9-Dehydroasterolide;Atractylenolide I, >99%;Atractylenolide I, 10 mM in DMSO;Eudesma-4(15),7(11),8-trien-12-olide
CBNumber
CB5847745
Molecular Formula
C15H18O2
Formula Weight
230.3
MOL File
73069-13-3.mol
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Atractylenolide-1 Property

Melting point:
121-123 °C(Solv: ligroine (8032-32-4))
Boiling point:
405.0±44.0 °C(Predicted)
Density 
1.12
Flash point:
170℃
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, clear, colorless
form 
powder
color 
White
InChI
InChI=1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1
InChIKey
ZTVSGQPHMUYCRS-SWLSCSKDSA-N
SMILES
O1C(=O)C(C)=C2C[C@]3([H])[C@@](C)(C=C12)CCCC3=C
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2737
Product name
Atractylenolide I
Purity
≥98% (HPLC)
Packaging
10mg
Price
$267.4
Updated
2025/07/31
Sigma-Aldrich
Product number
A2737
Product name
Atractylenolide I
Purity
≥98% (HPLC)
Packaging
50mg
Price
$1080
Updated
2023/06/20
Cayman Chemical
Product number
25061
Product name
Atractylenolide I
Purity
≥98%
Packaging
5mg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
25061
Product name
Atractylenolide I
Purity
≥98%
Packaging
10mg
Price
$267
Updated
2024/03/01
Cayman Chemical
Product number
25061
Product name
Atractylenolide I
Purity
≥98%
Packaging
25mg
Price
$455
Updated
2024/03/01
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Atractylenolide-1 Chemical Properties,Usage,Production

Description

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

Chemical Properties

Off-white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Atractylodes macrocephala Koidz.

Uses

Atractylenolide I (Standard) is the analytical standard of Atractylenolide I. This product is intended for research and analytical applications. Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.

References

[1] CUI-QIN LI  Ju Q J  Lang Chong He. Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages.[J]. Phytotherapy Research, 2007, 21 4: 347-353. DOI: 10.1002/ptr.2040
[2] CHANGHE WANG  Langchong H  Haijie Duan. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro[J]. European journal of pharmacology, 2009, 612 1: Pages 143-152. DOI: 10.1016/j.ejphar.2009.04.001
[3] RUI YU. Anti-tumor effects of Atractylenolide I on bladder cancer cells[J]. Journal of Experimental & Clinical Cancer Research, 2016, 110 1. DOI: 10.1186/s13046-016-0312-4
[4] HAIYAN GAO. Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress.[J]. Experimental and therapeutic medicine, 2018: 1574-1579. DOI: 10.3892/etm.2017.5517

Atractylenolide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Atractylenolide-1 Suppliers

China 240 Germany 1 United Kingdom 1 United States 17 Global 259
Naturewill Biotechnology Co., Ltd.
Tel
028-82632533 18113192475
Email
3157321941@qq.com
Country
China
ProdList
4993
Advantage
58
Shanghai Pureone Bio Technology, CO. LTD
Tel
18302135232 18302135232
Email
pureonebio@163.com
Country
China
ProdList
2973
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
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65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
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View Lastest Price from Atractylenolide-1 manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Atractylenolide-1 73069-13-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% HPLC
Supply Ability
1000kg
Release date
2022-10-18
Shaanxi Haibo Biotechnology Co., Ltd
Product
Atractylenolide I 73069-13-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
Shanghai Standard Technology Co., Ltd.
Product
Atractylenolide I 73069-13-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-29

73069-13-3, Atractylenolide-1Related Search:

Tea tree oil Yellow white oil Artemisia argyi oil LITSEA CUBEBA OIL Thyme Oil Rose Oil Fennel Oil Spikenard extract Costus oil Anise oil shechuangzhiyou Daurian Rhododendron Oil Cassia oil Anise Oil ATRACTYLENOLIDE Ⅲ 2-ATRACTYLENOLIDE Atractylenolide III Atractylenolide-1

  • Atractylenolide I, >99%
  • ATRACTYLENOLIDE-1
  • 3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one
  • Eudesma-4(15),7(11),8-trien-12-olide
  • 8,9-Dehydroasterolide
  • (4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide Ⅰ
  • Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
  • Atracylenolide I
  • Extracted oil
  • Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate
  • STAT,Atractylenolide I,Janus kinase,Inhibitor,JAK,Toll-like Receptor (TLR),inhibit
  • Dictyolactone I
  • (4aS,8aS)-3,8a-Dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide I-RM
  • Atractylenolide I, 10 mM in DMSO
  • 73069-13-3