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2-ATRACTYLENOLIDE

Product Name
2-ATRACTYLENOLIDE
CAS No.
73069-14-4
Chemical Name
2-ATRACTYLENOLIDE
Synonyms
ASTEROLIDE;Leucolactone II;2-ATRACTYLENOLIDE;Atractylenolide Ⅱ;Atractylenolide-2;Atracylenolide II;Atractylenolide Ⅱ;Atractylenolide II-RM;Atractylenolide II, BR;Atractylenolide II (Asterolide)
CBNumber
CB8847746
Molecular Formula
C15H20O2
Formula Weight
232.32
MOL File
73069-14-4.mol
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2-ATRACTYLENOLIDE Property

Melting point:
150-152 °C(Solv: ethyl ether (60-29-7))
Boiling point:
378.0±41.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in chloroform
form 
powder
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82480
Product name
Atractylenolide II
Purity
phyproof<SUP>&#174;</SUP> Reference Substance
Packaging
10 mg
Price
$408
Updated
2025/07/31
AK Scientific
Product number
X1091
Product name
AtractylenolideII
Packaging
10mg
Price
$212
Updated
2021/12/16
ApexBio Technology
Product number
N2205
Product name
2-Atractylenolide
Packaging
20mg
Price
$296
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0002404
Product name
ATRACTYLENOLIDE II
Purity
95.00%
Packaging
10MG
Price
$382.2
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA73866
Product name
AtractylenolideII
Packaging
50mg
Price
$408
Updated
2021/12/16
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2-ATRACTYLENOLIDE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Atractylodes macrocephala Koidz.

Uses

food and beverages

Definition

ChEBI: Atractylenolide II is a sesquiterpene lactone.

in vivo

Atractylenolide II (12.5-25 mg/kg; Oral gavage; 14 days) has antitumor effect in a B16 xenograft mouse model[3].
Atractylenolide II (10-60 mg/kg/d; Intraperitoneal injection; 8 weeks) improves myocardial fibrosis and oxidative stress in spontaneously hypertensive rats[4].

Animal Model:C57/BL6 mice with a B16 xenograft model[3]
Dosage:12.5 and 25 mg/kg
Administration:Oral gavage (i.g.); 14 days
Result:Significantly inhibited tumor growth.
Inhibited the activation/phosphorylation of STAT3 and Src.
Animal Model:Spontaneous hypertension rats[4]
Dosage:10, 30 and 60 mg/kg/d
Administration:Intraperitoneal injection (i.p.); 8 weeks
Result:Improved the body weight of spontaneous hypertension rats and enhanced myocardial function in a dose-dependent manner.
Effectively reduced cardiomyocyte apoptosis.
Inhibited the Collagen I, α-SMA, Fibronectin and Vimentin mRNA and protein expression levels.
Ameliorated oxidative stress by improving the activities of SOD and GSH-PX and lowering the contents of H2O2 and MDA, which reached about 80%.

IC 50

p-STAT3

2-ATRACTYLENOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ATRACTYLENOLIDE Suppliers

China 202 United Kingdom 1 United States 16 Global 219
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Fax
QQ：190129269
Email
winherb@126.com
Country
China
ProdList
1245
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
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View Lastest Price from 2-ATRACTYLENOLIDE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Atractylenolide II 73069-14-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
Shanghai Standard Technology Co., Ltd.
Product
Atractylenolide II 73069-14-4
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-29
Career Henan Chemical Co
Product
2-ATRACTYLENOLIDE 73069-14-4
Price
US $6.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg, 10kg ,50kg
Release date
2020-03-09

73069-14-4, 2-ATRACTYLENOLIDERelated Search:

Bakuchiol Psoralen HINOKIFLAVONE Epimedin A Cyasterone Isochlorogenic acid A SCHIZANDRIN B daurisoline (+)-Bicuculline benzoylpaeoniflorin CEPHAELINE HYDROCHLORIDE DAURICINE PULCHINENOSIDE B4 lithospermic acid ATRACTYLENOLIDE Ⅲ Atractylenolide-1 Atractylenolide III 2-ATRACTYLENOLIDE

  • ASTEROLIDE
  • 2-ATRACTYLENOLIDE
  • Atractylenolide II (Asterolide)
  • (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-Octahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide Ⅱ
  • Atractylenolide II, BR
  • Atracylenolide II
  • Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
  • Apoptosis,inhibit,Atractylenolide II,Inhibitor
  • Atractylenolide-2
  • Leucolactone II
  • (4aS,8aR,9aS)-3,8a-Dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide II-RM
  • Atractylenolide II, 10 mM in DMSO
  • Atractylenolide Ⅱ
  • 73069-14-4
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract