HINOKIFLAVONE

Product Name: HINOKIFLAVONE
CAS No.: 19202-36-9
Chemical Name: HINOKIFLAVONE
Synonyms: HINOKIFLAVONE;4',6''-BIAPIGENIN;4',6''-O-BIAPIGENIN;Hinokiflavone (6CI);4',5,5'',7,7''-Pentahydroxy-4''' 6-oxydiflavone;4''',5,5'',7,7''-Pentahydroxy(4',6''-oxybisflavone);Hinokiflavone, 98%, from Selaginella tamariscina (P. Beauv.) Spring;4',5,7-Trihydroxy-6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]flavone;6-(4-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
CBNumber: CB1686946
Molecular Formula: C30H18O10
Formula Weight: 538.46
MOL File: 19202-36-9.mol

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HINOKIFLAVONE Property

Melting point:: 353-355°C
Boiling point:: 841.5±65.0 °C(Predicted)
Density: 1.622
storage temp.: 2-8°C
solubility: Acetone: Soluble; Chloroform: Soluble; Dichloromethane: Soluble; DMSO: Soluble; Ethyl Acetate: Soluble
form: A solid
pka: 5.70±0.40(Predicted)
color: Light yellow to yellow
InChIKey: WTDHMFBJQJSTMH-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(O)C=C2)OC2=CC(O)=C(OC3=CC=C(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)C=C3)C(O)=C2C(=O)C=1
LogP: 5.528 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3416
Product name: Hinokiflavone
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: $103.55
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3416
Product name: Hinokiflavone
Purity: ≥97% (HPLC)
Packaging: 25MG
Price: $438
Updated: 2025/07/31

Usbiological

Product number: 300416
Product name: Hinokiflavone
Packaging: 5mg
Price: $581
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594003
Product name: Hinokiflavone
Packaging: 5mg
Price: $596.7
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH74127
Product name: Hinokiflavone
Packaging: 10mg
Price: $600
Updated: 2021/12/16

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HINOKIFLAVONE Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Selaginella tamariscina (P.Beauv.) Spring.

Uses

Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity[1][2][3].

Definition

ChEBI: A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic otential.

Biological Activity

Hinokiflavone is a plant biflavone th at exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.

in vivo

Hinokiflavone (25 or 50 mg/kg, i.p., daily for 24 days) has antitumor activity via suppressing tumor proliferation, metastasis and inducing Apoptosis in CT26 tumor-bearing mice^[2].
Hinokiflavone (100 mg/kg, s.c., every 12 h for 96 h) shows a protective effect on pneumonia infection by Improving survival rate in mice^[3].

Animal Model:	CT26 tumor-bearing mice model^[2]
Dosage:	25 or 50 mg/kg
Administration:	i.p., daily for 24 days
Result:	Resulted in retarded tumor progression and reduction of tumor weight without affecting body weight of mice, suppressed tumor proliferation and invasion ability by staining nuclear Ki-67 and MMP9, induced the apoptosis by staining cleaved caspase-3.

References

[1] Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402. DOI:10.7554/eLife.27402
[2] Zhou J, et al. Antitumor activity in colorectal cancer induced by hinokiflavone. J Gastroenterol Hepatol. 2019 Sep;34(9):1571-1580. DOI:10.1111/jgh.14581
[3] Kong X, et al. Hinokiflavone Attenuates the Virulence of Methicillin-Resistant Staphylococcus aureus by Targeting Caseinolytic Protease P. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0024022. DOI:10.1128/aac.00240-22

HINOKIFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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HINOKIFLAVONE Suppliers

China 143 Germany 2 India 1 Japan 1 United Kingdom 4 United States 14 USA 1 Global 166

Huzhou ZhanShu Biotechnology Co.,Ltd

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View Lastest Price from HINOKIFLAVONE manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Hinokiflavone 19202-36-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-16

Career Henan Chemical Co

Product: HINOKIFLAVONE 19202-36-9
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

19202-36-9, HINOKIFLAVONERelated Search:

(4-PHENOXYPHENYL)METHANOL HINOKIFLAVONE 6-METHOXYFLAVONE 2',5'-Dihydroxyacetophenone Monobenzone 3-Phenoxybenzaldehyde 3-PHENOXYTOLUENE 4-PHENOXYSTYRENE 4-Phenoxyphenol HISPIDULIN 2-Hydroxy-5-methoxybenzaldehyde Baicalein 2-Phenoxyphenol O-EUGENOL 2',3',4'-TRIHYDROXYACETOPHENONE SCUTELLAREIN 2,5-Dimethoxybenzaldehyde Eugenol

HINOKIFLAVONE

2-(4-Hydroxyphenyl)-5,7-dihydroxy-6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-4H-1-benzopyran-4-one

4''',5,5'',7,7''-Pentahydroxy(4',6''-oxybisflavone)

4',5,7-Trihydroxy-6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]flavone

6-[4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

4',5,5'',7,7''-Pentahydroxy-4''' 6-oxydiflavone

4',6''-BIAPIGENIN

4',6''-O-BIAPIGENIN

6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

Hinokiflavone, 98%, from Selaginella tamariscina (P. Beauv.) Spring

4H-1-Benzopyran-4-one, 6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-

Hinokiflavone (6CI)

6-(4-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

19202-36-9

Flavones