HINOKIFLAVONE
- Product Name
- HINOKIFLAVONE
- CAS No.
- 19202-36-9
- Chemical Name
- HINOKIFLAVONE
- Synonyms
- HINOKIFLAVONE;4',6''-BIAPIGENIN;4',6''-O-BIAPIGENIN;Hinokiflavone (6CI);4',5,5'',7,7''-Pentahydroxy-4''' 6-oxydiflavone;4''',5,5'',7,7''-Pentahydroxy(4',6''-oxybisflavone);Hinokiflavone, 98%, from Selaginella tamariscina (P. Beauv.) Spring;4',5,7-Trihydroxy-6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]flavone;6-(4-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
- CBNumber
- CB1686946
- Molecular Formula
- C30H18O10
- Formula Weight
- 538.46
- MOL File
- 19202-36-9.mol
HINOKIFLAVONE Property
- Melting point:
- 353-355°C
- Boiling point:
- 841.5±65.0 °C(Predicted)
- Density
- 1.622
- storage temp.
- 2-8°C
- solubility
- Acetone: Soluble; Chloroform: Soluble; Dichloromethane: Soluble; DMSO: Soluble; Ethyl Acetate: Soluble
- form
- A solid
- pka
- 5.70±0.40(Predicted)
- color
- Light yellow to yellow
- InChIKey
- WTDHMFBJQJSTMH-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(O)C=C2)OC2=CC(O)=C(OC3=CC=C(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)C=C3)C(O)=C2C(=O)C=1
- LogP
- 5.528 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML3416
- Product name
- Hinokiflavone
- Purity
- ≥97% (HPLC)
- Packaging
- 5MG
- Price
- $103.55
- Updated
- 2025/07/31
- Product number
- SML3416
- Product name
- Hinokiflavone
- Purity
- ≥97% (HPLC)
- Packaging
- 25MG
- Price
- $438
- Updated
- 2025/07/31
- Product number
- 300416
- Product name
- Hinokiflavone
- Packaging
- 5mg
- Price
- $581
- Updated
- 2021/12/16
- Product number
- FH74127
- Product name
- Hinokiflavone
- Packaging
- 2mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FH74127
- Product name
- Hinokiflavone
- Packaging
- 1mg
- Price
- $125
- Updated
- 2021/12/16
HINOKIFLAVONE Chemical Properties,Usage,Production
Chemical Properties
Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Selaginella tamariscina (P.Beauv.) Spring.
Uses
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity[1][2][3].
Definition
ChEBI: A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic otential.
Biological Activity
Hinokiflavone is a plant biflavone th at exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.
in vivo
Hinokiflavone (25 or 50 mg/kg, i.p., daily for 24 days) has antitumor activity via suppressing tumor proliferation, metastasis and inducing Apoptosis in CT26 tumor-bearing mice[2].
Hinokiflavone (100 mg/kg, s.c., every 12 h for 96 h) shows a protective effect on pneumonia infection by Improving survival rate in mice[3].
| Animal Model: | CT26 tumor-bearing mice model[2] |
| Dosage: | 25 or 50 mg/kg |
| Administration: | i.p., daily for 24 days |
| Result: | Resulted in retarded tumor progression and reduction of tumor weight without affecting body weight of mice, suppressed tumor proliferation and invasion ability by staining nuclear Ki-67 and MMP9, induced the apoptosis by staining cleaved caspase-3. |
References
[1] Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402. DOI:10.7554/eLife.27402
[2] Zhou J, et al. Antitumor activity in colorectal cancer induced by hinokiflavone. J Gastroenterol Hepatol. 2019 Sep;34(9):1571-1580. DOI:10.1111/jgh.14581
[3] Kong X, et al. Hinokiflavone Attenuates the Virulence of Methicillin-Resistant Staphylococcus aureus by Targeting Caseinolytic Protease P. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0024022. DOI:10.1128/aac.00240-22
HINOKIFLAVONE Preparation Products And Raw materials
Raw materials
Preparation Products
HINOKIFLAVONE Suppliers
View Lastest Price from HINOKIFLAVONE manufacturers
- Product
- Hinokiflavone 19202-36-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-16
- Product
- HINOKIFLAVONE 19202-36-9
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24