Atractylenolide-1

ChemicalBook > CAS DataBase List > Atractylenolide-1

Product Name: Atractylenolide-1
CAS No.: 73069-13-3
Chemical Name: Atractylenolide-1
Synonyms: Extracted oil;Dictyolactone I;Atracylenolide I;Atractylenolide Ⅰ;ATRACTYLENOLIDE-1;Atractylenolide I-RM;8,9-Dehydroasterolide;Atractylenolide I, >99%;Eudesma-4(15),7(11),8-trien-12-olide;Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate
CBNumber: CB5847745
Molecular Formula: C15H18O2
Formula Weight: 230.3
MOL File: 73069-13-3.mol

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Atractylenolide-1 Property

Melting point:: 121-123 °C(Solv: ligroine (8032-32-4))
Boiling point:: 405.0±44.0 °C(Predicted)
Density: 1.12
Flash point:: 170℃
storage temp.: 2-8°C
solubility: methanol: soluble1mg/mL, clear, colorless
form: powder
color: White
InChIKey: ZTVSGQPHMUYCRS-SWLSCSKDSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A2737
Product name: Atractylenolide I
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $371
Updated: 2024/03/01

Sigma-Aldrich

Product number: A2737
Product name: Atractylenolide I
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $1080
Updated: 2023/06/20

Cayman Chemical

Product number: 25061
Product name: Atractylenolide I
Purity: ≥98%
Packaging: 5mg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 25061
Product name: Atractylenolide I
Purity: ≥98%
Packaging: 10mg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 25061
Product name: Atractylenolide I
Purity: ≥98%
Packaging: 25mg
Price: $455
Updated: 2024/03/01

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Atractylenolide-1 Chemical Properties,Usage,Production

Description

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC₅₀s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID₅₀s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC₅₀s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

Atractylenolide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Atractylenolide-1 manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Atractylenolide-1 73069-13-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-18

Shaanxi Haibo Biotechnology Co., Ltd

Product: Atractylenolide I 73069-13-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

Shanghai Standard Technology Co., Ltd.

Product: Atractylenolide I 73069-13-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-29

73069-13-3, Atractylenolide-1Related Search:

Yellow white oil Artemisia argyi oil LITSEA CUBEBA OIL Thyme Oil Rose Oil Fennel Oil Spikenard extract Costus oil Anise oil shechuangzhiyou Daurian Rhododendron Oil Tea tree oil Cassia oil Anise Oil ATRACTYLENOLIDE Ⅲ 2-ATRACTYLENOLIDE Atractylenolide III Atractylenolide-1

Atractylenolide I, >99%

ATRACTYLENOLIDE-1

3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one

Eudesma-4(15),7(11),8-trien-12-olide

8,9-Dehydroasterolide

(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one

Atractylenolide Ⅰ

Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-

Atracylenolide I

Extracted oil

Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate

STAT,Atractylenolide I,Janus kinase,Inhibitor,JAK,Toll-like Receptor (TLR),inhibit

Dictyolactone I

(4aS,8aS)-3,8a-Dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one

Atractylenolide I-RM

73069-13-3