ChemicalBook > CAS DataBase List > N-Phenylhydroxylamine

N-Phenylhydroxylamine

Product Name
N-Phenylhydroxylamine
CAS No.
100-65-2
Chemical Name
N-Phenylhydroxylamine
Synonyms
NCI C-60093;N-HYDROXYANILINE;N-HYDROXYLANILINE;Hydroxyaminobenzene;Phenylhydroxylamine;N-Phenylhydroxyamine;N-Hydroxybenzenamine;N-Phenylhydroxylamin;N-Phenylhydroxylamine;BenzenaMine, N-hydroxy-
CBNumber
CB5851746
Molecular Formula
C6H7NO
Formula Weight
109.13
MOL File
100-65-2.mol
More
Less

N-Phenylhydroxylamine Property

Melting point:
80-84℃
Boiling point:
204.59°C (rough estimate)
Density 
1.1143 (rough estimate)
refractive index 
1.5444 (estimate)
storage temp. 
-20°C
pka
9.00±0.70(Predicted)
form 
solid
color 
Light brown
Water Solubility 
20g/L(5 ºC)
Stability:
Unstable - deteriorates with storage. Incompatible with strong oxidizing agents.
EPA Substance Registry System
Phenylhydroxylamine (100-65-2)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
NC4900000
HazardClass 
6.1
PackingGroup 
HS Code 
2928009090
Hazardous Substances Data
100-65-2(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
671576
Product name
N-Phenylhydroxylamine
Purity
≥97.0% (GC)
Packaging
1g
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
671576
Product name
N-Phenylhydroxylamine
Purity
≥97.0% (GC)
Packaging
5g
Price
$307
Updated
2024/03/01
Usbiological
Product number
459603
Product name
N-Phenylhydroxylamine
Packaging
1g
Price
$403
Updated
2021/12/16
Adipogen Life Sciences
Product number
CDX-P0103-G001
Product name
N-Phenylhydroxylamine
Purity
≥98%(HPLC)
Packaging
1g
Price
$76
Updated
2021/12/16
Apolloscientific
Product number
OR933342
Product name
N-Phenylhydroxylamine
Packaging
250mg
Price
$142
Updated
2021/12/16
More
Less

N-Phenylhydroxylamine Chemical Properties,Usage,Production

Chemical Properties

tan powder or crystals

Uses

N-Phenylhydroxylamine can be used as a starting material for the synthesis of:

  • 2-alkylindoles by treating with aliphatic terminal alkynes using gold catalyst via sequential 3,3-rearrangements and cyclodehydrations.
  • Isoxazolidines by reacting with aldehydes and α, β-unsaturated aldehydes via a three-component one-pot catalytic reaction.
  • Tetrahydro-1,2-oxazines by treating with an aldehyde and cyclopropane via homo 3+2 dipolar cycloaddition reaction.

Uses

Manufacture of cupferron.

Definition

ChEBI: N-phenylhydroxylamine is an N-substituted amine that is a derivative of aniline in which one of the amino hydrogen atoms is replaced with a hydroxy substituent.

Preparation

To a dispersion of 180 gm (2.75 gm-atom) of zinc dust in 500 ml of 50% aqueous ethanol, with vigorous stirring, is added 130 ml (156 gm, 1.27 mole) of nitrobenzene. The reaction is initiated by the dropwise addition of an aqueous ammonium chloride solution and can thereafter be maintained at a controllable rate by the cautious addition of the remaining ammonium chloride solution. The reaction temperature rises during this reduction step. Once reflux has subsided, the basic zinc salts are filtered off using a sintered glass funnel. The light green filtrate is cooled in an ice-salt mixture to precipitate the product. The yield is 100 gm (72.2%), m.p. 81°C.
The reduction of 2-methyl-2-nitropropane is carried out in a similar manner at 10-20°C to afford a 68% yield of N-t-butylhydroxylamine (m.p. 60-62°C).

General Description

Tan to brown crystals.

Air & Water Reactions

Soluble in hot water.

Reactivity Profile

N-Phenylhydroxylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for N-Phenylhydroxylamine are not available but N-Phenylhydroxylamine is probably nonflammable.

Safety Profile

Poison by ingestion and subcutaneous routes. Human systemic effects by skin contact: primary irritation. Preparative hazard. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Impure base deteriorates rapidly. Crystallise it from H2O, *C6H6 or *C6H6/pet ether (40-60o). The picrate has m 186o (from EtOH), and the benzenesulfonate salt has m 70o (dec )(EtOH/*C6H6). [Beilstein 15 H 2, 15 I 3, 15, II 4, 15 III 5. 15 IV 4.]

N-Phenylhydroxylamine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-Phenylhydroxylamine Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Zhengzhou Kingsfine Chemical Co., Ltd.
Tel
0371-56632527 13838252817
Fax
0371-56635027
Email
sales@kingsfine.com
Country
China
ProdList
98
Advantage
62
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1541
Advantage
55
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai Aonan chemical technology co.,ltd.
Tel
Email
info@aonanchem.com
Country
China
ProdList
65
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
More
Less

View Lastest Price from N-Phenylhydroxylamine manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
N-Phenylhydroxylamine 100-65-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
10000kg
Release date
2024-08-23
Henan Fengda Chemical Co., Ltd
Product
N-Phenylhydroxylamine 100-65-2
Price
US $8.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-29
Career Henan Chemical Co
Product
N-Phenylhydroxylamine 100-65-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04