Heptafluorobutyric acid
- Product Name
- Heptafluorobutyric acid
- CAS No.
- 375-22-4
- Chemical Name
- Heptafluorobutyric acid
- Synonyms
- HFBA;Perfluorobutanoic acid;PERFLUOROBUTYRIC ACID;2,2,3,3,4,4,4-Heptafluorobutanoic acid;PERFLUOROBUTYRATE;Perfluorobutanoicaid;heptafluorobutanoicacid;FC-23;H 0024;NSC 820
- CBNumber
- CB5853573
- Molecular Formula
- C4HF7O2
- Formula Weight
- 214.04
- MOL File
- 375-22-4.mol
Heptafluorobutyric acid Property
- Melting point:
- -17.5 °C
- Boiling point:
- 120 °C755 mm Hg(lit.)
- Density
- 1.645 g/mL at 25 °C(lit.)
- vapor density
- 7 (vs air)
- vapor pressure
- ~10 mm Hg ( 25 °C)
- refractive index
- n20/D 1.3(lit.)
- Flash point:
- 120-121°C
- storage temp.
- Store below +30°C.
- solubility
- Chloroform: soluble; Methanol: soluble
- form
- Powder
- pka
- pK1:0.17 (25°C)
- Specific Gravity
- approximate 1.6
- color
- Clear colorless to faint yellow
- PH
- 1 (H2O, 20℃)
- Water Solubility
- miscible
- Sensitive
- Light Sensitive
- BRN
- 1426882
- InChIKey
- YPJUNDFVDDCYIH-UHFFFAOYSA-N
- CAS DataBase Reference
- 375-22-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Butanoic acid, heptafluoro-(375-22-4)
- EPA Substance Registry System
- Heptafluorobutyric acid (375-22-4)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-35
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- RTECS
- ET4025000
- F
- 3-8-10
- Hazard Note
- Corrosive
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29159000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 8.43443
- Product name
- Heptafluorobutyric acid
- Purity
- for synthesis
- Packaging
- 5ML
- Price
- $43.8
- Updated
- 2024/03/01
- Product number
- 8.43443
- Product name
- Heptafluorobutyric acid
- Purity
- for synthesis
- Packaging
- 25ML
- Price
- $75.9
- Updated
- 2024/03/01
- Product number
- 52411
- Product name
- Heptafluorobutyric acid
- Purity
- for ion chromatography, ≥99.5% (GC)
- Packaging
- 5ml
- Price
- $46.6
- Updated
- 2024/03/01
- Product number
- 52411
- Product name
- Heptafluorobutyric acid
- Purity
- for ion chromatography, ≥99.5% (GC)
- Packaging
- 25mL
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 164194
- Product name
- Heptafluorobutyric acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $31.7
- Updated
- 2024/03/01
Heptafluorobutyric acid Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to faintly yellow liquid
Uses
Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.
Uses
Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.
Uses
Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.
Definition
ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.
General Description
Perfluorobutyric acid is an effective additive for zinc electrodeposition.
Hazard
Irritant to tissue.
Purification Methods
Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]
Heptafluorobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Heptafluorobutyric acid manufacturers
- Product
- Heptafluorobutyric acid 375-22-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 95% ,98%
- Supply Ability
- 10000
- Release date
- 2023-04-29
- Product
- Heptafluorobutyric acid 375-22-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200KG
- Release date
- 2018-08-15